BFR in Overweight Sedentary Subjects

Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects

This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

Study Overview

• Status: Completed
• Conditions: Overweight
• Intervention / Treatment: Other: Exercise Intervention

Detailed Description

The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients.

3.2 Primary and secondary endpoints

The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns.

The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol.

3.3 Study design

This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • VD
    • Lausanne, VD, Switzerland, 1015
      • ISSUL

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• IMC between 25 and 35
• vaccin against Covid-19

Exclusion Criteria:

hypertension diabete

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Blood Flow Restriction; Use of the BFR cuff during the training intervention	Other: Exercise Intervention; Training with light load with blood flow restriction (BFR)
Active Comparator: control; No use of inflated cuff	Other: Exercise Intervention; Training with light load with blood flow restriction (BFR)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
DEXA technology	Body composition assessment: relative lean and fat mass in all body segments	One week before intervention
DEXA technology	Body composition assessment: relative lean and fat mass in all body segments	One week following the training intervention
Evaluation of muscle strength from an isokinetic device	eccentric and concentric peak torque of the knee extensor muscles	One week before intervention
Evaluation of muscle strength from an isokinetic device	eccentric and concentric peak torque of the knee extensor muscles	One week following the training intervention
Evaluation of the preferential speed of walking in an ecological situation	using of a treadmill with measurement of the ground reaction forces	One week before interventionn
Evaluation of the preferential speed of walking in an ecological situation	using of a treadmill with measurement of the ground reaction forces	One week following the training intervention
Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.	calculation of the mechanical work	One week before intervention
Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.	calculation of the mechanical work	One week following the training intervention
Evaluation of the energy cost of walking	on a treadmill, by indirect calorimetry with gaz exchanges	One week before intervention
Evaluation of the energy cost of walking	on a treadmill, by indirect calorimetry with gaz exchanges	One week following the training intervention

Collaborators and Investigators

• Sponsor: University of Lausanne

Study record dates

Study Major Dates

• Study Start (Actual): February 1, 2022
• Primary Completion (Actual): April 15, 2022
• Study Completion (Actual): April 15, 2022

Study Registration Dates

• First Submitted: April 19, 2022
• First Submitted That Met QC Criteria: May 6, 2022
• First Posted (Actual): May 12, 2022

Study Record Updates

• Last Update Posted (Actual): May 12, 2022
• Last Update Submitted That Met QC Criteria: May 6, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Keywords: blood flow restriction
• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: 2021-02081

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No