Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD) (POSIBIL6ESKD)

May 29, 2026 updated by: CSL Behring

A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis

This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study.

Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo. Part 2: Phase 3 aims to assess the efficacy of CSL300 vs placebo on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

Study Overview

Study Type

Interventional

Enrollment (Estimated)

3110

Phase

  • Phase 2
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

      • Banfield, Argentina, 1828
        • Recruiting
        • FME Lomas de Zamora
      • Buenos Aires, Argentina, 1425
        • Recruiting
        • FME Mansilla
      • Buenos Aires, Argentina, 6022
        • Recruiting
        • Instituto de Trasplante De La Ciudad Autonoma De Buenos Aires
      • Buenos Aires, Argentina, B1870ARU
        • Recruiting
        • FME Avellaneda
      • Ciudad Autonoma, Argentina, C1431FWO
        • Recruiting
        • FME Cemic Saavedra
      • Ciudad Evita, Argentina, B1778IFA
        • Recruiting
        • Fresenius Medical Care - Ciudad Evita
      • Ciudad de Buenos Aires, Argentina, C1426
        • Recruiting
        • CEREHA
      • Córdoba, Argentina, 5016
        • Recruiting
        • Clinica Privada Velez Sarsfield
      • Formosa, Argentina, 3600
        • Recruiting
        • FME Formosa
      • Hurlingham, Argentina, B 1686
        • Recruiting
        • STR Hurlingham SRL
      • Mar del Plata, Argentina, 7600
        • Recruiting
        • Nextdial S.A.
      • Morón, Argentina, B1708DPO
        • Recruiting
        • Fresenius Medical Care - Nostri Centri Dialisi - Moron
      • Rosario, Argentina, S2000DEJ
        • Recruiting
        • Instituto Medico de la Fundacion de Estudios Clínicos
      • San Miguel de Tucumán, Argentina, 4000
        • Recruiting
        • Fresenius Tucumán
      • Bundaberg, Australia, 4670
        • Recruiting
        • Wide Bay Hospital and Health Service
        • Contact:
          • Trial Information Contact
      • Heidelberg, Australia, 3084
        • Recruiting
        • Austin Hospital
        • Contact:
          • Trial Information Contact
      • Liverpool, Australia, 2170
        • Recruiting
        • Liverpool Hospital
      • Murdoch, Australia, 6150
        • Recruiting
        • Fiona Stanley Hospital
        • Contact:
          • Use Central Contact
      • Nambour, Australia, 4560
        • Recruiting
        • Sunshine Coast University Private Hospital
        • Contact:
          • Use Central Contact
      • Parkville, Australia, 3052
        • Recruiting
        • Royal Melbourne Hospital
        • Contact:
          • Trial Information Contact
      • Southport, Australia, 4215
        • Recruiting
        • Gold Coast University Hospital
        • Contact:
          • Use Central Contact
      • Urraween, Australia, 4655
        • Recruiting
        • Fraser Coast Renal Service, Hervey Bay Hospital
        • Contact:
          • Trial Information Contact
      • Wahroonga, Australia, 2076
        • Recruiting
        • Sydney Adventist Hospital
        • Contact:
          • Trial Information Contact
      • Westmead, Australia, 2145
        • Recruiting
        • Westmead Hospital
        • Contact:
          • Use Central Contact
      • Wollongong, Australia, 2500
        • Recruiting
        • Wollongong Renal Unit
        • Contact:
          • Use Central Contact
    • New South Wales
      • Saint Leonards, New South Wales, Australia, 2065
        • Recruiting
        • Royal North Shore Hospital (RNSH)
        • Contact:
          • Use Central Contact
      • Sydney, New South Wales, Australia, 2139
        • Recruiting
        • Concord Repatriation General Hospital
        • Contact:
          • Use Central Contact
    • Queensland
      • Cairns, Queensland, Australia, 4870
        • Recruiting
        • Cairns Hospital
        • Contact:
          • Use Central Contact
      • Nambour, Queensland, Australia, 4560
        • Suspended
        • Sunshine Coast University Private Hospital
      • Woolloongabba, Queensland, Australia, 4102
        • Suspended
        • Princess Alexandra Hospital
    • Victoria
      • Clayton, Victoria, Australia, 3168
        • Recruiting
        • Monash Medical Centre
        • Contact:
          • Use Central Contact
      • St Albans, Victoria, Australia, 3021
        • Recruiting
        • Sunshine Hospital
        • Contact:
          • Use Central Contact
      • Vienna, Austria, 1130
        • Recruiting
        • Wiener Gesundheitsverbund - Klinik Hietzing
        • Contact:
          • Trial Information Contact
      • Aalst, Belgium, 9300
        • Recruiting
        • Onze-Lieve-Vrouwziekenhuis VZW
        • Contact:
          • Use Central Contact
      • Bonheiden, Belgium, 2820
        • Recruiting
        • Imelda Ziekenhuis
        • Contact:
          • Use Central Contact
      • Charleroi, Belgium, 6042
        • Recruiting
        • Centre Hospitalier Universitaire (CHU) de Charleroi - Hopital Civil Marie Curie
      • Ghent, Belgium, 9000
        • Suspended
        • AZ Sint-Lucas
      • La Louvière, Belgium, 7100
        • Recruiting
        • Centre Hospitalier Universitaire de Tivoli
        • Contact:
          • Use Central Contact
      • Leper, Belgium, 8900
        • Recruiting
        • Jan Yperman Ziekenhuis
      • Leuven, Belgium, 3000
        • Recruiting
        • Universitair Ziekenhuis Leuven
        • Contact:
          • Use Central Contact
      • Liège, Belgium, 4000
        • Recruiting
        • CHR de la Citadelle
        • Contact:
          • Use Central Contact
      • Roeselare, Belgium, 8800
        • Recruiting
        • AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke
        • Contact:
          • Use Central Contact
      • Sint-Niklaas, Belgium, 9100
        • Recruiting
        • VITAZ, Department Nierziekten & Dialyse
        • Contact:
          • Trial Information Contact
      • Belo Horizonte, Brazil, 30150-320
        • Recruiting
        • Santa Casa de Misericordia de Belo Horizonte
      • Belo Horizonte, Brazil, 30220-140
        • Recruiting
        • NUPEC-Nucleo de Pesquisa Clinica
      • Fortaleza, Brazil, 60430-372
        • Recruiting
        • Hospital Universitário Walter Cantídio (Fortaleza)
      • Joinville, Brazil, 89227-680
        • Recruiting
        • Fundacao Pro Rim de Santa Catarina
      • Maringá, Brazil, 87060-040
        • Recruiting
        • Clipem - Clínica o Pesquisa Endocrinológica de Maringá
      • Passo Fundo, Brazil, 9910-260
        • Recruiting
        • Hospital de Clinicas de Passo Fundo
      • Porto Alegre, Brazil, 90035-074
        • Recruiting
        • Irmandade Santa Casa de Misericordia de Porto Alegre
      • Porto Alegre, Brazil, 90035-903
        • Recruiting
        • Hospital De Clinicas De Porto Alegre
      • Porto Alegre, Brazil, 90610-001
        • Recruiting
        • Hospital Sao Lucas da PUCRS
      • Praia Do Canto, Brazil, 29055-450
        • Recruiting
        • CEDOES - Centro de Diagnostico e Pesquisa
      • Ribeirão Preto, Brazil, 14015-130
        • Recruiting
        • Universidade de Sao Paulo (USP)-Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP)
      • Ribeirão Preto, Brazil, 14025-170
        • Recruiting
        • SERVIÇO DE NEFROLOGIA DE RIBEIRÃO Preto (SENERP)
      • Salvador, Brazil, 40415-065
        • Recruiting
        • Clinica Senhor do Bonfim Ltda (CSB) - Monte Serrat
      • São José do Rio Preto, Brazil, 15090-000
        • Recruiting
        • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
      • São Paulo, Brazil, 01323-020
        • Recruiting
        • Hospital Alemao Oswaldo Cruz
      • São Paulo, Brazil, 08270-070
        • Recruiting
        • Hospital Santa Marcelina
      • São Paulo, Brazil, 04024-002
        • Recruiting
        • Hospital do Rim e Hipertensão
      • São Paulo, Brazil, 1409-902
        • Recruiting
        • Hospital 9 De Julho
      • São Paulo, Brazil, 01246-903
        • Recruiting
        • Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
      • Dobrich, Bulgaria, 9300
        • Recruiting
        • Multiprofile Hospital for Active Treatment - Dobrich AD
      • Gabrovo, Bulgaria, 5300
        • Recruiting
        • Multiprofile Hospital For Active Treatment Dr Tota Venkova
        • Contact:
          • Trial Information Contact
      • Lom, Bulgaria, 3600
        • Recruiting
        • Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD
        • Contact:
          • Use Central Contact
      • Montana, Bulgaria, 3400
        • Recruiting
        • Dialysis Centre Montana
      • Plovdiv, Bulgaria, 4002
        • Recruiting
        • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
        • Contact:
          • Trial Information Contact
      • Plovdiv, Bulgaria, 4003
        • Recruiting
        • UMHAT Plovdiv
        • Contact:
          • Trial Information Contact
      • Sliven, Bulgaria, 6600
        • Recruiting
        • Multiprofile Hospital for Active Treatment Dr. Ivan Seliminski - Sliven AD
        • Contact:
          • Trial Information Contact
      • Smolyan, Bulgaria, 4700
        • Recruiting
        • Medical Center - Smolyan OOD
        • Contact:
          • Use Central Contact
      • Sofia, Bulgaria, 1527
        • Recruiting
        • University Hospital for Active Treatment Tsaritsa Joanna ISUL EAD
      • Sofia, Bulgaria, 1432
        • Recruiting
        • UMHAT Aleksandrovska
      • Stara Zagora, Bulgaria, 6000
        • Recruiting
        • Dialysis Center VIA DIAL OOD
        • Contact:
          • Use Central Contact
      • Stara Zagora, Bulgaria, 6000
        • Recruiting
        • UMHAT Prof. Dr. Stoyan Kirkovich
        • Contact:
          • Trial Information Contact
      • Longueuil, Canada, J4V 2H1
        • Recruiting
        • Hospital Charles Lemoyne
      • Montreal, Canada, H1T 2M4
      • Montreal, Canada, H2X 3E4
        • Recruiting
        • CHUM - Centre hospitalier de l'Université de Montréal
        • Contact:
          • Use Central Contact
      • Ottawa, Canada, K1H 8L6
        • Recruiting
        • The Ottawa Hospital Research Institute
      • Sherbrooke, Canada, J1H 5N4
        • Recruiting
        • Ciussse-Chus
        • Contact:
          • Trial Information Contact
      • Toronto, Canada, M5B 1W8
        • Recruiting
        • St. Michaels Hospital
        • Contact:
          • Use Central Contact
      • Vancouver, Canada, V6Z 1Y6
        • Recruiting
        • St Paul Hospital
        • Contact:
          • Trial Information Contact
      • Winnipeg, Canada, R2V 3M3
        • Recruiting
        • Seven Oaks Hospital
        • Contact:
          • Trial Information Contact
    • Alberta
      • Edmonton, Alberta, Canada, T6G2P4
        • Recruiting
        • University of Alberta Hospital
        • Contact:
          • Use Central Contact
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A6
        • Recruiting
        • Queen Elizabeth II Health Sciences Centre
        • Contact:
    • Ontario
      • Hamilton, Ontario, Canada, L8N 4A6
        • Recruiting
        • St. Josephs Healthcare Hamilton
        • Contact:
          • Use Central Contact
      • Kingston, Ontario, Canada, K7L 2V7
        • Recruiting
        • Kingston Health Sciences Centre
        • Contact:
      • London, Ontario, Canada, N6A 5A5
        • Recruiting
        • London Health Sciences Centre - University Hospital
        • Contact:
          • Use Central Contact
      • Oshawa, Ontario, Canada, L1G 2B9
        • Recruiting
        • Lakeridge Health Oshawa
        • Contact:
          • Use Central Contact
    • Quebec
      • Montreal, Quebec, Canada, H4A 3J1
        • Recruiting
        • McGill University Health Centre
        • Contact:
          • Use Central Contact
      • Montreal, Quebec, Canada, H4J 1C5
      • Baotou Shi, China, 14040
        • Recruiting
        • Inner Mongolia Baotou City Central Hospital (Baotou Central Hospital)
      • Beijeing, China, 100033
        • Recruiting
        • Peking University People's Hospital
      • Beijing, China, 100191
        • Recruiting
        • Peking University Third Hospital
      • Beijing, China, 100034
        • Recruiting
        • Peking University First Hospital
        • Contact:
          • Use Central Contact
      • Beijing, China, 102218
        • Recruiting
        • Beijing Tsinghua Chang Gung Hospital
        • Contact:
          • Trial Information Contact
      • Beijing, China, 100068
        • Recruiting
        • China Rehabilitation Research Center (Beijing Boai Hospital)
      • Beijing, China, 101500
        • Recruiting
        • Beijing Miyun Hospital
      • Dalian, China, 116001
        • Recruiting
        • The Affiliated Zhongshan Hospital (Dalian Railroad Hospital)
      • Deyang Shi, China, 618000
        • Recruiting
        • People's Hospital of Deyang
        • Contact:
          • Trial Information Contact
      • Dongguan, China, 523059
        • Recruiting
        • Dongguan People's Hospital
      • Guangzhou, China, 510700
        • Recruiting
        • The Fifth Affiliated Hospital of Guangzhou Medical University
      • Hefei, China, 230601
        • Recruiting
        • Anhui Medical University-The Second Hospital
        • Contact:
          • Trial Information Contact
      • Jiaxing, China, 314001
        • Recruiting
        • The First Hospital of Jiaxing
      • Lanzhou, China, 730000
        • Recruiting
        • Gansu Provincial People's Hospital
        • Contact:
          • Trial Information Contact
      • Lanzhou, China, 210029
        • Recruiting
        • Jiangsu Province Hospital /The First Affiliated Hospital with Nanjing Medical University
      • Luoyang Shi, China, 471003
        • Recruiting
        • Henan University of Science and Technology-The First Affiliated Hospital
      • Mianyang, China, 621000
        • Recruiting
        • The Third Hospital of Mianyang
      • Nanchang, China, 330006
        • Recruiting
        • Nanchang University - The First Affiliated Hospital
        • Contact:
          • Trial Information Contact
      • Nanjing, China, 210003
        • Recruiting
        • The Second Affiliated Hospital of Nanjing Medical University
      • Nanjing, China, 210029
        • Recruiting
        • Jiangsu Province Hospital of Chinese Medicine
      • Nanning, China, 530021
        • Recruiting
        • The People's Hospital Guangxi Zhuang of Autonomous Region
        • Contact:
          • Trial Information Contact
      • Pingxiang, China, 337055
        • Recruiting
        • Southern Medical University - Jiangxi Pingxiang People's Hospital
        • Contact:
          • Trial Information Contact
      • Shanghai, China, 200001
        • Recruiting
        • Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital
        • Contact:
          • Trial Information Contact
      • Shanghai Shi, China, 200080
        • Recruiting
        • Shanghai First People's Hospital
        • Contact:
          • Trial Information Contact
      • Shenzhen, China, 518035
        • Recruiting
        • Shenzhen Second People's Hospital (Shenzhen University First Affiliated Hospital)
      • Shijiazhuang, China, 50011
        • Recruiting
        • The Fourth Hospital of Hebei Medical University
      • Shijiazhuang, China, 050011
        • Recruiting
        • Shijiazhuang People's Hospital
        • Contact:
          • Trial Information Contact
      • Taiyuan, China, 030001
        • Recruiting
        • Second Hospital of Shanxi Medical University
        • Contact:
          • Trial Information Contact
      • Tianjin, China, 300071
        • Recruiting
        • Tianjin People's Hospital
        • Contact:
          • Trial Information Contact
      • Wuhan, China, 430014
        • Recruiting
        • Huazhong University of Science and Technology - Tongji Medical College - The Central Hospital of Wuhan (Wuhan Second Hospital)
        • Contact:
          • Trial Information Contact
      • Wuhan, China, 430060
        • Recruiting
        • Renmin Hospital of Wuhan University/Hubei General Hospital
      • Wuxi, China, 214023
        • Recruiting
        • Wuxi People's Hospital
        • Contact:
          • Trial Information Contact
      • Xiamen, China, 361004
        • Recruiting
        • Zhongshan Hospital Xiamen University
        • Contact:
          • Trial Information Contact
      • Xianyang, China, 712099
        • Recruiting
        • Yan'an University Xianyang Hospital
        • Contact:
          • Trial Information Contact
      • Xinxiang, China, 453000
        • Recruiting
        • Xinxiang City First People's Hospital
        • Contact:
          • Trial Information Contact
      • Yangzhou, China, 225001
        • Recruiting
        • Northern Jiangsu People's Hospital
        • Contact:
          • Trial Information Contact
      • Yibin, China, 644000
        • Recruiting
        • Yibin Second People's Hospital
        • Contact:
          • Trial Information Contact
      • Zhengzhou, China, 450052
        • Recruiting
        • The first affiliated hospital of Zhengzhou university
      • Zhenjiang, China, 212001
        • Recruiting
        • Affiliated Hospital of Jiangsu University
        • Contact:
          • Use Central Contact
      • Hradec Králové, Czechia, 500 05
        • Recruiting
        • Fakultni Nemocnice Hradec Kralove (FNHK) - Hemodialyzacni Stredisko (HDS)
      • Nový Jičín, Czechia, 741 01
        • Recruiting
        • Nemocnice AGEL Novy Jicin a.s
      • Ostrava, Czechia, 708 00
        • Recruiting
        • Fakultní Nemocnice Ostrava (FNO) - Interni Klinika
      • Prague, Czechia, 100 34
        • Recruiting
        • Fakultni nemocnice Kralovske Vinohrady
      • Český Krumlov, Czechia, 381 01
        • Recruiting
        • Interni Oddeleni Nemocnice
      • Aalborg, Denmark, 9000
        • Recruiting
        • Aalborg Universitetshospital
        • Contact:
          • Use Central Contact
      • Herlev, Denmark, 2730
        • Recruiting
        • Herlev Hospital
        • Contact:
          • Use Central Contact
      • Herning, Denmark, 7400
        • Recruiting
        • Gødstrup Hospital
        • Contact:
          • Use Central Contact
      • Hillerød, Denmark, 3400
        • Recruiting
        • Trail Nation: Nordsjællands Hospital
        • Contact:
          • Use Central Contact
      • Holbæk, Denmark, 4300
        • Recruiting
        • Trial Nation: Holbæk Sygehus
      • Amiens, France, 80054
        • Recruiting
        • CHU Amiens - Nephrology Dialysi Transplantation Department
        • Contact:
          • Use Central Contact
      • Aura, France, 42055
        • Recruiting
        • CHU de Saint-Etienne - Hopital Nord
        • Contact:
          • Use Central Contact
      • Brest, France, 29200
        • Recruiting
        • Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche
        • Contact:
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      • Caen, France, 14000
        • Recruiting
        • CHU de Caen
        • Contact:
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      • Compiègne, France, 60200
        • Recruiting
        • Polyclinique Saint Come - Centre de Dialyse
      • Grabels, France, 34790
        • Recruiting
        • Fondation Charles Mion AIDER Santé
        • Contact:
          • Trial Information Contact
      • Lille, France, 59000
        • Recruiting
        • Hôpital privé La Louvière
        • Contact:
          • Trial Information Contact
      • Limoges, France, 87042
        • Recruiting
        • CHU de Limoges
        • Contact:
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      • Marseille, France, 13005
        • Recruiting
        • Hopitaux Universitaires de Marseille
      • Montpellier, France, 34295
        • Recruiting
        • Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie
        • Contact:
          • Use Central Contact
      • Nice, France, 6000
        • Recruiting
        • CHE de Nice - Pasteur Hospital
      • Nîmes, France, 30029
        • Recruiting
        • CHU de Nimes - Hopital Universitaire Caremeau
        • Contact:
          • Trial Information Contact
      • Paris, France, 75013
        • Recruiting
        • Hôpital Pitié-Salpêtrière
        • Contact:
          • Trial Information Contact
      • Paris, France, 75014
        • Recruiting
        • AURA Paris - Plaisance
        • Contact:
          • Use Central Contact
      • Reims, France, 51092
        • Recruiting
        • Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche
        • Contact:
          • Trial Information Contact
      • Saint-Ouen, France, 93400
        • Recruiting
        • AURA St Quen Dialysis centre
        • Contact:
          • Use Central Contact
      • Strasbourg, France, 67091
        • Recruiting
        • Hôpitaux Universitaires de Strasbourg - Hôpital Civil
        • Contact:
          • Use Central Contact
      • Toulouse, France, 31059
        • Recruiting
        • CHU Rangueil
        • Contact:
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      • Berlin, Germany, 13353
        • Recruiting
        • Charite-Universitatsmedizin Berlin
        • Contact:
          • Use Central Contact
      • Hessen, Germany, 64732
        • Recruiting
        • Nierenzentrum Bad König
        • Contact:
          • Use Central Contact
      • Kaiserslautern, Germany, 67655
        • Recruiting
        • Westpfalz Klinikum GmbH
        • Contact:
          • Use Central Contact
      • Kiel, Germany, 24105
        • Suspended
        • UKSH - Universitatsklinik Schleswig-Holstein
      • Leipzig, Germany, 04129
        • Recruiting
        • Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg
        • Contact:
          • Trial Information Contact
      • Mainz, Germany, 55131
        • Recruiting
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
        • Contact:
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      • Villingen-Schwenningen, Germany, 78052
        • Recruiting
        • Nephrologisches Zentrum Villingen-Schwenningen
        • Contact:
          • Use Central Contact
      • Alexandroupoli, Greece, 68100
        • Recruiting
        • University Hospital of Alexandroupolis
        • Contact:
          • Use Central Contact
      • Arta, Greece, 471 00
        • Recruiting
        • General Hospital of Arta
        • Contact:
          • Use Central Contact
      • Crete, Greece, 71500
        • Recruiting
        • University General Hospital of Heraklion
        • Contact:
          • Use Central Contact
      • Haidari, Greece, 12461
        • Recruiting
        • Mesogeios Nephrology Center
      • Ioannina, Greece, 45110
        • Recruiting
        • University General Hospital of Ioannina
        • Contact:
          • Use Central Contact
      • Ioannina, Greece, 45445
        • Recruiting
        • General Hospital of Ioannina G. Hatzikosta
        • Contact:
          • Use Central Contact
      • Larissa, Greece, 41110
        • Recruiting
        • Nephrological Clinic University Hospital, University of Thessaly
        • Contact:
          • Use Central Contact
      • Marousi, Greece, 15123
        • Recruiting
        • Mitera Hospital, Hemodialysis Unit
      • Ptolemaida, Greece, 50200
        • Recruiting
        • General Hospital of Ptolemaida
        • Contact:
          • Trial Information Contact
      • Rio, Greece, 265 04
        • Recruiting
        • University Hospital of Patras
        • Contact:
          • Use Central Contact
      • Thessaloniki, Greece, 56403
        • Recruiting
        • Papageorgiou General Hospital Of Thessaloniki
        • Contact:
          • Use Central Contact
      • Thessaloniki, Greece, 45500
        • Recruiting
        • AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki
        • Contact:
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      • Thessaloniki, Greece, 54642
        • Recruiting
        • Aristotle University, Hippokration
        • Contact:
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      • Thessaloniki, Greece, 55134
        • Recruiting
        • General Hospital of Thessaloniki, Agios Pavlos
        • Contact:
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      • Thessaloniki, Greece, 570 10
        • Recruiting
        • Nephrology Department G. Papanikolaou General Hospital
        • Contact:
          • Use Central Contact
      • Ho Man Tin, Hong Kong, 999077
        • Recruiting
        • Princess Margaret Hospital
      • Pok Fu Lam, Hong Kong, 852
        • Recruiting
        • Queen Mary Hospital Hong Kong
      • Tsuen Wan, Hong Kong, 999077
        • Recruiting
        • Yan Chai Hospital
      • Kaposvár, Hungary, 7400
        • Recruiting
        • Somogy Megyei Kaposi Mor Oktato Korhaz
      • Kistarcsa, Hungary, 2143
        • Recruiting
        • B. Braun Avitum - 14. Dialízisközpont Kistarcs
        • Contact:
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      • Afula, Israel, 18105
        • Recruiting
        • Emek Medical Center
      • Ashkelon, Israel, 7830604
        • Recruiting
        • Barzilai Medical Center
      • Haifa, Israel, 3436212
        • Recruiting
        • Carmel Medical Center
        • Contact:
          • Use Central Contact
      • Holon, Israel, 58100
        • Recruiting
        • Edith Wolfson Medical Center
        • Contact:
          • Use Central Contact
      • Nahariya, Israel, 2244624
        • Recruiting
        • Galilee Medical Center
      • Petah Tikva, Israel, 4941492
        • Recruiting
        • Rabin Medical Center
        • Contact:
          • Use Central Contact
      • Ramat Gan, Israel, 3109601
        • Recruiting
        • Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center )
        • Contact:
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      • Rehovot, Israel, 7661041
        • Recruiting
        • Kaplan Medical Center
      • Safed, Israel, 13110
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        • Ziv Medical Center
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      • Tel Aviv, Israel, 84100
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        • Ichilov Hospital-Tel-Aviv Sourasky Medical Center
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      • Tiberias, Israel, 15208
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        • Medical Research & Development Fund for Health Services, PORIYA Hospital
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      • Bologna, Italy, 40138
        • Recruiting
        • Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
      • Brescia, Italy, 25123
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        • Asst Degli Spedali Civili Di Brescia
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      • Cagliari, Italy, 9100
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        • Azienda Ospedaliera Brotzu
      • Caserta, Italy, 81100
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        • Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta
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      • Catania, Italy, 95121
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        • AOU Policlinico G Rodolico - San Marco - Presidio Ospedaliero ospedale San Marco
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      • Ferrara, Italy, 44124
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        • Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna
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      • Florence, Italy, 50012
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        • Ospedale Santa Maria Annunziata
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      • Foggia, Italy, 71122
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        • A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp
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      • Genova, Italy, 16132
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        • IRCCS Az. Osp. Universitaria San Martino- IST
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      • Lecce, Italy, 73100
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        • Vito Fazzi Hospital in Lecce
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      • Lecco, Italy, 23900
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        • ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco
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      • Messina, Italy, 98124
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        • Università degli Studi di Messina
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      • Milan, Italy, 20132
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        • IRCCS Ospedale San Raffaele
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      • Milan, Italy, 20142
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        • ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo
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      • Milan, Italy, 20162
        • Recruiting
        • ASST Great Metropolitan Hospital Niguarda
      • Naples, Italy, 80138
        • Recruiting
        • AOU L. Vanvitelli Universita degli Studi della Campania Luigi Vanvitelli
      • Novara, Italy, 28100
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        • Ospedale Maggiore di Novara
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      • Pavia, Italy, 2700
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        • ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS
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      • Peschiera del Garda, Italy, 37019
        • Recruiting
        • University of Verona
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      • Piacenza, Italy, 29121
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        • AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine
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      • Pisana, Italy, 56124
        • Recruiting
        • Azienda Ospedaliero Universitaria Pisana - Ospedale di Cisanello - Stabilimento Ospedaliero di Cisanello
      • Prato, Italy, 59100
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        • Ospedale Santo Stefan
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      • Reggio Calabria, Italy, 89124
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        • Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
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      • Rimini, Italy, 47923
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        • Rimini Hospital
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      • Roma, Italy, 168
        • Recruiting
        • Policlinico A. Gemelli Universitario
      • Rome, Italy, 00122
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        • Azienda Unita Sanitaria Locale (USL) Roma 3 (AUSL RM 3) - Presidio Ospedaliero Giovan Battista Grassi
      • Rome, Italy, 1577
        • Recruiting
        • Sandro Pertini Hospital
      • San Giovanni Rotondo, Italy, 71013
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        • Ospedale Casa Sollievo della Sofferenza (CSS)
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      • Verona, Italy, 37126
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        • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
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      • Hashima-gun, Japan, 501-6062
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        • Matsunami General Hospital
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      • Higashiosaka-shi, Japan, 579-8026
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        • Ishikiriseiki Hospital
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      • Hiroshima, Japan, 739-0696
        • Recruiting
        • NHO Hiroshimanishi Medical Center
      • Hokkaido, Japan, 041-1121
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        • Miki Internal Medicine Urology Clinic
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      • Inashiki-gun, Japan, 300-0332
        • Recruiting
        • Tokyo Medical University Ibaraki Medical Center
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      • Kagoshima, Japan, 890-0073
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        • Ueyama Hospital
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      • Kagoshima, Japan, 890-0073
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        • Ueyama Jin Clinic
      • Kamakura-Shi, Japan, 247-8533
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        • Shonan Kamakura General Hospital
      • Kanazawa, Japan, 920-8650
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        • National Hospital Organization Kanazawa Medical Center
      • Kitakyushu-Shi, Japan, 802-8555
        • Recruiting
        • Kokura Memorial Hospital
      • Kurume, Japan, 830-0011
        • Recruiting
        • Kurume University Hospital
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      • Kurume-shi, Japan, 830-8543
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        • St. Mary's Hospital
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      • Kyoto, Japan, 607-8116
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        • Rakuwakai Otowa Kinen Hospital
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      • Matsubara-shi, Japan, 580-0032
        • Recruiting
        • Matsubara Tokushukai Hospital
      • Nagaoka-Shi, Japan, 940-2085
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        • Nagaoka Red-Cross Hospital
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      • Nagoya, Japan, 455-8530
        • Recruiting
        • Chubu Rosai Hospital
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      • Nagoya, Japan, 457-8511
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        • Daido Hospital
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      • Ogaki-Shi, Japan, 503-0015
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        • Ogaki Tokushukai Hospital
      • Oyama-shi, Japan, 323-0831
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        • Oguranaika Jin Cinic
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      • Sakaimachi, Japan, 306-0433
        • Recruiting
        • Ibaraki Seinan Medical Center Hospital
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      • Takasaki-Shi, Japan, 370-1203
        • Recruiting
        • Kurosawa Hospital
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      • Tsukuba, Japan, 305-0861
        • Recruiting
        • Kikuchi Medical Clinic
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      • Ube-shi, Japan, 755-0155
        • Recruiting
        • St.Hill Hospital
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      • Yamagata, Japan, 990-0834
        • Recruiting
        • Yamagata Tokushukai Hospital
      • Yokohama, Japan, 231-0048
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        • Bosei Kannai Clinic
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      • Yonago-shi, Japan, 683-8605
        • Recruiting
        • Sanin Rosai Hospital
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      • Ōmihachiman, Japan, 523-0082
        • Recruiting
        • Omihachiman Community Medical Center - Kidney Center
        • Contact:
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    • Aichi-ken
      • Ichinomiya-shi, Aichi-ken, Japan, 491-8551
        • Recruiting
        • Daiyukai Daiichi Hospital
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    • Chiba
      • Urayasu-shi, Chiba, Japan, 279-0021
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        • Juntendo University Urayasu Hospital
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    • Fukuoka
      • Kitakyushu-shi, Fukuoka, Japan, 805-0050
        • Recruiting
        • Steel Memorial Yawata Hospital
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    • Gunma
      • Maebashi, Gunma, Japan, 371-0022
        • Recruiting
        • Maebashi Hirosegawa Clinic
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      • Maebashi, Gunma, Japan, 371-0046
        • Recruiting
        • Joumou Ohashi Clinic
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    • Hokkaido
      • Sapporo, Hokkaido, Japan, 006-0816
        • Recruiting
        • Teine Urological Clinic
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    • Shiga
      • Kusatsu-shi, Shiga, Japan, 525-8585
        • Recruiting
        • Omi freai Hospital
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    • Tokyo
      • Shinjuku-Ku, Tokyo, Japan, 162-8666
        • Recruiting
        • Tokyo Womens Med University
        • Contact:
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      • Ipoh, Malaysia, 31400
        • Recruiting
        • Hospital Raja Permaisuri Bainun, Ipoh
      • Kota Kinabalu, Malaysia, 88300
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        • Queen Elizabeth Hospital
      • Lembah Pantai, Malaysia, 59100
        • Recruiting
        • University Malaya Medical Centre
      • Pejabat Pakar, Malaysia, 50586
        • Recruiting
        • Hospital Kuala Lumpur
      • Perai, Malaysia, 13700
        • Recruiting
        • Seberang Jaya Hospital
      • Perak, Malaysia, 32040
        • Recruiting
        • Seri Manjung Hospital
      • Drammen, Norway, 3004
        • Recruiting
        • Vestre Viken HF - Drammen Sykehus (Sykehuset Buskerud)
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      • Grålum, Norway, 1714
        • Recruiting
        • Sykehuset Østfold Kalnes
      • Skien, Norway, 3710
        • Recruiting
        • Sykehuset Telemark
      • Brodnica, Poland, 87-300
        • Recruiting
        • Davita Stacja Dializ w Brodnicy
      • Katowice, Poland, 40-027
        • Recruiting
        • Slaski Uniwersytet Medyczny (SUM) w Katowicach
      • Lodz, Poland, 90-153
        • Recruiting
        • Uniwersytecki Szpital Kliniczny Nr. 1 im. Norberta Barlickiego
      • Lodz, Poland, 92-213
        • Recruiting
        • Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodz, Klinika Nefrologii, Hipertensjologii i Transplantologii Nerek
      • Pszczyna, Poland, 43-200
        • Recruiting
        • DaVita Stacja Dializ
      • Stalowa Wola, Poland, 37-450
        • Recruiting
        • Powiatowy Szpital Specjalistyczny w Stalowej Woli
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      • Szczecin, Poland, 70-111
        • Recruiting
        • Samodzielny Publiczny Szpital Kliniczny Nr. 2 Pomorski Uniwersytet Medyczny w Szczecinie
      • Tczew, Poland, 83-110
        • Recruiting
        • Diaverum - NZOZ Tczewie
        • Contact:
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      • Warsaw, Poland, 01-211
        • Recruiting
        • DaVita Stacja Dializ
        • Contact:
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      • Warsaw, Poland, 04-349
        • Recruiting
        • Wojskowy Instytut Medyczny (WIM) - Centralny Szpital Kliniczny (CSK) MON - Klinika Chorob Wewnetrznych
      • Łęczna, Poland, 21-010
        • Recruiting
        • Davita-Łęczna
      • Braga, Portugal, 4710-243
        • Recruiting
        • Unidade Local de Saúde de Braga, E. P. E.
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      • Canelas-V.N.Gaia, Portugal, 4410-313
        • Recruiting
        • Caledial - Centro de Hemodiálise de Gaia
      • Carregado, Portugal, 2580-588
        • Recruiting
        • NephroCare Carregado
      • Faro, Portugal, 8055-546
        • Recruiting
        • Nephrocare Faro
      • Lisbon, Portugal, 1050-099
        • Recruiting
        • Centro Hospitalar e Universitário de Lisboa Centra
      • Lisbon, Portugal, 1400-195
        • Recruiting
        • Fresenius Medical Care - NephroCare - Unidade de Hemodialise do Restelo
      • Loures, Portugal, 2674-514
        • Recruiting
        • Unidade Local de Saúde de Loures -Odivelas, E. P. E.
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      • Oeiras, Portugal, 2790
        • Recruiting
        • Unidade Local de Saúde de São José, E. P. E.
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      • Porto, Portugal, 4099-001
        • Recruiting
        • Unidade Local de Saúde de Santo António, E. P. E.
        • Contact:
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      • Porto, Portugal, 4470-235
        • Recruiting
        • Fresenius NephroCare
      • Torres Novas, Portugal, 2354-754
        • Recruiting
        • Unidade Local de Saúde do Médio Tejo, E. P. E.
      • Vila Franca de Xira, Portugal, 2600-009
        • Recruiting
        • Unidade Local de Saúde do Estuário do Tejo, E. P. E.
        • Contact:
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      • Humacao, Puerto Rico, 791
        • Recruiting
        • Legacy Senior Living
      • Brasov, Romania, 500152
        • Recruiting
        • Centrul de Dializa Fresenius NephroCare Brasov
      • Bucharest, Romania, 22328
        • Recruiting
        • Fundeni Clinical Institute
        • Contact:
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      • Bucharest, Romania, 203512
        • Recruiting
        • Centrul de Dializa Fresenius NephroCare Bucaresti
      • Bucharest, Romania, 60044
        • Recruiting
        • Centrul de Nefrologie si Dializa DIAVERUM Sema Parc
      • Bucharest, Romania, 77085
        • Recruiting
        • Centrul de Nefrologie si Dializa Diaverum Fundeni
      • Bucharest, Romania, 042122
        • Recruiting
        • SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center
        • Contact:
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      • Bucharest, Romania, 060044
        • Recruiting
        • Centrul De Nefrologie si Dializa DIAVERUM SPLAI
      • Cluj-Napoca, Romania, 400505
        • Recruiting
        • Centrul de Dializa Fresenius NephroCare Cluj
      • Constanța, Romania, 900001
        • Recruiting
        • Centrul de Dializa Fresenius NephroCare Constanta
      • Constanța, Romania, 900591
        • Recruiting
        • Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta)
        • Contact:
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      • Craiova, Romania, 200349
        • Recruiting
        • Centrul de Nefrologie si Dializa Diaverum Craiova
      • Deva, Romania, 33081
        • Recruiting
        • Spitalul Judetean de Urgenta Deva
      • Iași, Romania, 700503
        • Recruiting
        • Spitalul Clinic -Dr. C.I. Parhon - Iasi
        • Contact:
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      • Oradea, Romania, 410057
        • Recruiting
        • Spitalul Clinic Municipal Dr. Gavril Curteanu Oradea
      • Ploieşti, Romania, 100551
        • Recruiting
        • Centrul de Dializa Fresenius NephroCare Ploiesti
      • Satu Mare, Romania, 440055
        • Recruiting
        • Spital Judetean de Urgenta Satu Mare
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      • Târgu Mureş, Romania, 540487
        • Recruiting
        • Centrul Medical de Nefrologie si Dializa Diaverum Targu Mures
      • Levice, Slovakia, 934 01
        • Recruiting
        • Nefrologicka ambulancia Levice - FMC dialyzacne sluzby, s.r.o.
      • Lučenec, Slovakia, 98401
        • Recruiting
        • LC-REN s.r.o.
        • Contact:
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      • Púchov, Slovakia, 020 01
        • Recruiting
        • Biodial, s.r.o.
      • Anyang-si, South Korea, 14068
        • Recruiting
        • Hallym University Sacred Heart Hospital
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      • Daegu, South Korea, 42601
        • Recruiting
        • Keimyung University Dongsan Medical Center
        • Contact:
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      • Gangnam-gu, South Korea, 6273
        • Recruiting
        • Gangnam Severance Hospital
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      • Goyang-si, South Korea, 10444
        • Recruiting
        • National Health Insurance Service - Ilsan Hospital
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      • Guri-si, South Korea, 11923
        • Recruiting
        • Hanyang University Guri Hospital
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      • Gwangju, South Korea, 5030
        • Recruiting
        • Konkuk University Medical Center
        • Contact:
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      • Seoul, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital
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      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University
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      • Wŏnju, South Korea, 26426
        • Recruiting
        • Yonsei University - Wonju Severance Christian Hospital
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    • Seoul
      • Ilsan-gu, Seoul, South Korea, 7061
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        • SMG - SNU Boramae Medical Center
        • Contact:
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      • Alcobendas, Spain, 28100
        • Recruiting
        • Centro de dialisis Alcobendas
      • Barcelona, Spain, 08907
        • Recruiting
        • Hospital Universitari de Bellvitge (IDIBELL)
      • Barcelona, Spain, 8035
        • Recruiting
        • Hospital Universitario Valle de Hebron
      • Córdoba, Spain, 14005
        • Recruiting
        • University Hospital Reina Sofía
      • Girona, Spain, 17007
        • Recruiting
        • Hospital Universitari de Girona Dr Josep Trueta, (Avitum)
        • Contact:
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      • Granada, Spain, 18014
        • Recruiting
        • Hospital Universitario Virgen de las Nieves
      • Guadalajara, Spain, 19002
        • Recruiting
        • Universidad de Alcala (UAH)
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      • Lleida, Spain, 25198
        • Recruiting
        • Hospital Universitari Arnau de Vilanova
        • Contact:
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      • Madrid, Spain, 28040
        • Recruiting
        • Hospital Clinico San Carlos
      • Madrid, Spain, 28006
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        • Hospital Universitario de la Princesa
      • Madrid, Spain, 28040
        • Recruiting
        • Hospital Universitario Fundacion Jimenez Diaz
      • Madrid, Spain, 28007
        • Recruiting
        • Universitario Gregorio Marañón
      • Madrid, Spain, 28806
        • Recruiting
        • Hospital Universitario Príncipe de Asturias
      • Manises, Spain, 46940
        • Recruiting
        • Hospital de Manises
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      • Palma de Mallorca, Spain, 7120
        • Recruiting
        • Hospital Universitari Son Espases
      • Santiago de Compostela, Spain, 15706
        • Recruiting
        • CHUS - H. Clinico U. de Santiago
      • Seville, Spain, 41009
        • Recruiting
        • Hospital Universitario Virgen de la Macarena
      • Terrassa, Spain, 8223
        • Recruiting
        • Fresenius Medical Care Centro de Diálisis Terrassa
      • Valencia, Spain, 46026
        • Recruiting
        • Hospital Universitari i Politecnic La Fe
        • Contact:
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      • Valencia, Spain, 46017
        • Recruiting
        • Centro Hospital Universitario Dr. Preset
      • Valencia, Spain, 46010
        • Recruiting
        • Hospital Clinico Universitario - Valencia
        • Contact:
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      • Huddinge, Sweden, 14186
        • Recruiting
        • Karolinska Huddinge
      • Stockholm, Sweden, 113 65
        • Recruiting
        • Region Stockholm-SLSO
      • Uppsala, Sweden, 75185
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        • Uppsala Universitet - Akademiska Sjukhuset
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      • Kaohsiung City, Taiwan, 807
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • New Taipei City, Taiwan, 220216
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        • Far Eastern Memorial Hospital
      • New Taipei City, Taiwan, 235041
        • Recruiting
        • Taipei Medical University Shuang Ho Hospital
      • Taichung, Taiwan, 40705
        • Recruiting
        • Taichung Veterans General Hospital
      • Taipei, Taiwan, 110
        • Recruiting
        • Taipei Medical University - Taipei Medical University Hospital
      • Amphoe Mueang, Thailand, 30000
        • Recruiting
        • Maharat Nakhon Ratchasima Hospital
      • Bangkok, Thailand, 10400
        • Recruiting
        • Ramathibodi Hospital
      • Chiang Mai, Thailand, 50200
        • Recruiting
        • Chiang Mai University
      • Ankara, Turkey (Türkiye), 6230
        • Recruiting
        • Hacettepe University,Faculty of Medicine
      • Antalya, Turkey (Türkiye), 7070
        • Recruiting
        • Akdeniz University Medical Faculty Hospital
      • Atakum, Turkey (Türkiye), 55280
        • Recruiting
        • Ondokuz Mayis Üniversitesi
      • Bakırköy, Turkey (Türkiye), 34147
        • Recruiting
        • İstanbul Bakirköy Dr.Sadi Konuk Eğitim Araştirma Hastanesi
      • Bornova, Turkey (Türkiye), 35100
        • Recruiting
        • Ege University Hospital
      • Edirne, Turkey (Türkiye), 22030
        • Recruiting
        • Trakya Üniversitesi Tıp Fakültesi
      • Kahramanmaraş, Turkey (Türkiye), 46040
        • Recruiting
        • Kahramanmaras Sutcu Imam University - Tip Fakultesi (Kahramanmaras Sutcu Imam University Faculty of Medicine)
      • Yeşilyurt, Turkey (Türkiye), 44000
        • Recruiting
        • Malatya Education and Research Hospital
      • İzmit, Turkey (Türkiye), 41000
        • Recruiting
        • Kocaeli University, Medical Faculty, Division of Nephrology
      • Birmingham, United Kingdom, B9 5SS
        • Recruiting
        • University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH)
        • Contact:
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      • Bradford, United Kingdom, BD9 6RJ
        • Recruiting
        • Bradford Teaching Hospitals NHS Foundation Trust
        • Contact:
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      • Coventry, United Kingdom, CV2 2DX
        • Recruiting
        • University Hospital Coventry and Warwickshire
        • Contact:
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      • Derby, United Kingdom, DE22 3NE
        • Recruiting
        • University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital
        • Contact:
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      • Dorchester, United Kingdom, DT1 2JY
        • Recruiting
        • Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH)
        • Contact:
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      • Liverpool, United Kingdom, L7 8XP
        • Recruiting
        • Royal Liverpool University Hospital
        • Contact:
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      • London, United Kingdom, E1 1BB
        • Recruiting
        • William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital
        • Contact:
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      • London, United Kingdom, SE5 9RS
        • Recruiting
        • King´s College NHS Trust
        • Contact:
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      • London, United Kingdom, SW17 0QT
        • Recruiting
        • St George's University Hospitals NHS Foundation Trust - St G
        • Contact:
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      • London, United Kingdom, W12 0HS
        • Recruiting
        • Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre
        • Contact:
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      • Londonderry, United Kingdom, BT47 6SB
        • Recruiting
        • Altnagelvin Area Hospital
        • Contact:
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      • Salford, United Kingdom, M6 8HD
        • Recruiting
        • Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation
        • Contact:
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      • Shrewsbury, United Kingdom, SY3 8XQ
        • Recruiting
        • The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital
        • Contact:
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      • Stoke-on-Trent, United Kingdom, ST4 6QG
        • Recruiting
        • Royal Stoke University Hospital
        • Contact:
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      • Wolverhampton, United Kingdom, WV10 0QP
        • Recruiting
        • The Royal Wolverhampton NHS Trust - New Cross Hospital
        • Contact:
          • Use Central Contact
    • Alabama
      • Decatur, Alabama, United States, 35601
        • Recruiting
        • Nephrology of North Alabama
      • Huntsville, Alabama, United States, 35805
        • Recruiting
        • Nephrology Consultants, LLC
        • Contact:
          • Use Central Contact
      • Montgomery, Alabama, United States, 36117
        • Recruiting
        • DaVita Clinical Research Montgomery
        • Contact:
          • Use Central Contact
    • Arizona
      • Glendale, Arizona, United States, 85305
        • Recruiting
        • AKDHC Medical
        • Contact:
          • Use Central Contact
      • Glendale, Arizona, United States, 91206
        • Recruiting
        • Kidney Disease Medical Group
        • Contact:
          • Use Central Contact
      • Phoenix, Arizona, United States, 85018
        • Recruiting
        • AKDHC Medical
        • Contact:
          • Use Central Contact
      • Tucson, Arizona, United States, 85723
        • Recruiting
        • Southern Arizona VA Health Care System
        • Contact:
          • Trial Information Contact
      • Tucson, Arizona, United States, 85705
        • Recruiting
        • AKDHC Medical
        • Contact:
          • Use Central Contact
    • California
      • Bakersfield, California, United States, 93309
        • Recruiting
        • National Institute Of Clinical Research
        • Contact:
          • Use Central Contact
      • Beverly Hills, California, United States, 90211
        • Recruiting
        • Amicis Research Center
        • Contact:
          • Use Central Contact
      • Chula Vista, California, United States, 91910
        • Recruiting
        • California Institute of Renal Research
        • Contact:
          • Use Central Contact
      • Fresno, California, United States, 93720
        • Recruiting
        • The Medical Research Group, Inc.
      • Fullerton, California, United States, 92832
        • Recruiting
        • Davita Fullerton Dialysis Center
        • Contact:
          • Use Central Contact
      • Fullerton, California, United States, 92835
        • Recruiting
        • National Institute of Clinical Research, Inc.
        • Contact:
          • Use Central Contact
      • Garden Grove, California, United States, 92844
        • Recruiting
        • National Institute Of Clinical Research
        • Contact:
          • Use Central Contact
      • Garden Grove, California, United States, 92843
        • Recruiting
        • National Institute of Clinical Research, Inc.
        • Contact:
          • Use Central Contact
      • Garden Grove, California, United States, 92843
        • Recruiting
        • St. Jude Medical Center
        • Contact:
          • Use Central Contact
      • Glendale, California, United States, 91206
        • Recruiting
        • Kidney Disease Medical Group
        • Contact:
          • Use Central Contact
      • Glendale, California, United States, 91204
        • Recruiting
        • Sherman Medical Group, Inc
        • Contact:
          • Use Central Contact
      • Granada Hills, California, United States, 91344
        • Recruiting
        • Renal Consultants Medical Group
        • Contact:
          • Use Central Contact
      • La Jolla, California, United States, 92037
        • Recruiting
        • Balboa Research
        • Contact:
          • Trial Information Contact
      • La Mesa, California, United States, 91942
        • Recruiting
        • California Institute of Renal Research
        • Contact:
          • Use Central Contact
      • La Palma, California, United States, 90623
        • Recruiting
        • Southern California Medical Research Center
        • Contact:
          • Use Central Contact
      • Los Angeles, California, United States, 90048
        • Recruiting
        • Cedars-Sinai Medical Center
      • Los Angeles, California, United States, 90022
        • Recruiting
        • Academic Medical Research Institute
        • Contact:
          • Use Central Contact
      • Los Angeles, California, United States, 90027
        • Recruiting
        • National Institute of Clinical Research, Inc.
        • Contact:
          • Use Central Contact
      • Los Angeles, California, United States, 90033
        • Suspended
        • DaVita Carabello Dialysis Center
      • Lynwood, California, United States, 90262
        • Recruiting
        • Renal Medical Associates/NARI
        • Contact:
          • Use Central Contact
      • Northridge, California, United States, 91324
        • Recruiting
        • Amicis Research Center
        • Contact:
          • Use Central Contact
      • Oxnard, California, United States, 93036
        • Recruiting
        • FORMAT Medical Research
        • Contact:
          • Use Central Contact
      • Riverside, California, United States, 92504
        • Recruiting
        • Van Buren Dialysis Center
        • Contact:
          • Use Central Contact
      • Riverside, California, United States, 92505
        • Recruiting
        • National Nephrology Alliance Research - Riverside
        • Contact:
          • Use Central Contact
      • Salinas, California, United States, 93901
        • Recruiting
        • Central Coast Nephrology Medical Corp
        • Contact:
          • Use Central Contact
      • San Diego, California, United States, 92111
        • Recruiting
        • California Institute of Renal Research
        • Contact:
          • Use Central Contact
      • San Diego, California, United States, 92123
        • Suspended
        • California Institute of Renal Research
      • San Dimas, California, United States, 91773
        • Recruiting
        • North America Research Institute
        • Contact:
          • Use Central Contact
      • San Jose, California, United States, 95126
        • Suspended
        • Satellite Healthcare
      • Tarzana, California, United States, 91356
        • Recruiting
        • Valiance Clinical Research
        • Contact:
          • Use Central Contact
      • Tarzana, California, United States, 91356
        • Recruiting
        • Nephrology Educational Services
        • Contact:
          • Use Central Contact
      • Vacaville, California, United States, 95687
        • Recruiting
        • Amicis Research Center
        • Contact:
          • Use Central Contact
      • Victorville, California, United States, 92392
        • Recruiting
        • National Institute of Clinical Research, Inc
        • Contact:
          • Use Central Contact
      • Victorville, California, United States, 92394
        • Recruiting
        • DaVita Vista Del Sol Dialysis
        • Contact:
          • Use Central Contact
    • Colorado
      • Arvada, Colorado, United States, 80002
        • Recruiting
        • Western Nephrology
        • Contact:
      • Denver, Colorado, United States, 80230
        • Recruiting
        • Colorado Kidney Care
        • Contact:
          • Use Central Contact
      • Denver, Colorado, United States, 80210
        • Recruiting
        • Kidney Associates of Colorado, P.C.
        • Contact:
          • Use Central Contact
    • Connecticut
      • Bloomfield, Connecticut, United States, 06002
        • Recruiting
        • Greater Hartford Nephrology, LLC
        • Contact:
          • Use Central Contact
      • Middlebury, Connecticut, United States, 06762
        • Recruiting
        • Nephrology and Hypertension Associates PC
        • Contact:
          • Use Central Contact
    • Delaware
      • Newark, Delaware, United States, 19713
        • Recruiting
        • Nephrology Associates (Delaware)
        • Contact:
          • Use Central Contact
    • Florida
      • Boca Raton, Florida, United States, 33431
        • Recruiting
        • - Boca Raton Regional - Research Physicians Network Alliance
        • Contact:
          • Use Central Contact
      • Bradenton, Florida, United States, 34209
      • Brooksville, Florida, United States, 34613
        • Recruiting
        • Access Research Institute
        • Contact:
          • Trial Information Contact
      • Coral Gables, Florida, United States, 33134
        • Recruiting
        • Horizon Research Group LLC
        • Contact:
          • Use Central Contact
      • Coral Springs, Florida, United States, 33071
        • Recruiting
        • South Florida Nephrology Group, PA
        • Contact:
          • Use Central Contact
      • Hialeah Gardens, Florida, United States, 33016
        • Recruiting
        • Family First Medical Research Center
        • Contact:
          • Use Central Contact
      • Hollywood, Florida, United States, 33021
        • Recruiting
        • Royal Research, Corp
      • Hollywood, Florida, United States, 33021
        • Recruiting
        • Advanced Medical Research Group
        • Contact:
          • Use Central Contact
      • Hollywood, Florida, United States, 33024
        • Recruiting
        • Elixia Pines
        • Contact:
          • Use Central Contact
      • Lauderdale Lakes, Florida, United States, 33313
        • Recruiting
        • South Florida Research Institute
        • Contact:
          • Use Central Contact
      • Medley, Florida, United States, 33166
        • Recruiting
        • South Florida Research Organization LLC
        • Contact:
          • Use Central Contact
      • Miami, Florida, United States, 33126
        • Recruiting
        • Total Research Group, LLC
        • Contact:
          • Use Central Contact
      • Miami, Florida, United States, 33173
        • Recruiting
        • Nephrology Associates of South Miami
        • Contact:
          • Use Central Contact
      • Miami, Florida, United States, 33125
        • Recruiting
        • Aviva Health Sciences
      • Miami, Florida, United States, 33126
        • Recruiting
        • Iconic Clinical Research Center
        • Contact:
          • Use Central Contact
      • Miami, Florida, United States, 33150
        • Recruiting
        • Kidney and Hypertension Specialists of Miami
        • Contact:
          • Use Central Contact
      • Miami Lakes, Florida, United States, 33016
        • Recruiting
        • Floridian Clinical Research
        • Contact:
          • Use Central Contact
      • Orlando, Florida, United States, 32806
        • Recruiting
        • Elixia Central Florida
        • Contact:
          • Use Central Contact
      • Sanford, Florida, United States, 32771
        • Recruiting
        • Infigo Clinical Research LLC
      • Tampa, Florida, United States, 33603
        • Suspended
        • Genesis Clinical Research
      • Temple Terrace, Florida, United States, 33637
        • Recruiting
        • Florida Kidney Specialists
        • Contact:
          • Use Central Contact
      • Winter Park, Florida, United States, 32789
        • Recruiting
        • Florida Premier Research Institute
        • Contact:
          • Use Central Contact
    • Georgia
      • Albany, Georgia, United States, 31701
        • Recruiting
        • Southwest Georgia Nephrology Clinic
        • Contact:
          • Use Central Contact
      • Brunswick, Georgia, United States, 31520
        • Recruiting
        • Coastal Medical Research, LLC
        • Contact:
          • Use Central Contact
      • Columbus, Georgia, United States, 31904
        • Recruiting
        • Renal Associates LLC
        • Contact:
          • Use Central Contact
      • Cordele, Georgia, United States, 31015
        • Recruiting
        • National Clinical Trials
      • Douglasville, Georgia, United States, 30101
        • Recruiting
        • American Clinical Trials
        • Contact:
          • Use Central Location
      • Lawrenceville, Georgia, United States, 30046
        • Recruiting
        • Georgia Nephrology
        • Contact:
      • Statesboro, Georgia, United States, 30458
        • Completed
        • Atekha Nephrology Clinic LLC
    • Indiana
      • Fort Wayne, Indiana, United States, 46804
        • Recruiting
        • NANI Research
        • Contact:
          • Trial Information Contact
      • Mishawaka, Indiana, United States, 46545
        • Recruiting
        • Nephrology Physician's LLC
        • Contact:
          • Use Central Contact
    • Iowa
      • Sioux City, Iowa, United States, 57049
        • Recruiting
        • Dunes Clinical Research LLC
        • Contact:
          • Use Central Contact
    • Kansas
      • Wichita, Kansas, United States, 67214
        • Recruiting
        • Kansas Nephrology Physicians, PA
        • Contact:
          • Use Central Contact
    • Kentucky
      • Louisville, Kentucky, United States, 40205
        • Recruiting
        • Nephrology Associates of Kentuckiana, PSC
        • Contact:
          • Use Central Contact
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70808
        • Recruiting
        • Renal Associates of Baton Rouge
        • Contact:
          • Use Central Contact
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Recruiting
        • Massachusetts General Hospital
        • Contact:
      • Boston, Massachusetts, United States, 02111
        • Recruiting
        • Tufts Medical Center
    • Michigan
      • Kalamazoo, Michigan, United States, 49007
        • Recruiting
        • Paragon Health, Inc
        • Contact:
          • Use Central Contact
      • Pontiac, Michigan, United States, 48341
        • Recruiting
        • Michigan Kidney Consultants, PC
        • Contact:
          • Use Central Contact
      • Roseville, Michigan, United States, 48066
        • Recruiting
        • St. Clair Nephrology Research
        • Contact:
          • Use Central Contact
      • Saint Clair Shores, Michigan, United States, 48081
        • Recruiting
        • Center for Advanced Kidney Research, PLC
        • Contact:
          • Use Central Contact
    • Minnesota
      • Minneapolis, Minnesota, United States, 55404
        • Completed
        • DCR Edina
      • Minneapolis, Minnesota, United States, 55404
        • Recruiting
        • DCR Edina
        • Contact:
          • Use Central Contact
      • Minneapolis, Minnesota, United States, 55439
        • Recruiting
        • Minneapolis VA Health Care System
    • Mississippi
      • Brookhaven, Mississippi, United States, 39601
        • Completed
        • Southwest Mississippi Nephrology PLLC
      • Columbus, Mississippi, United States, 39705
        • Recruiting
        • Nephrology Associates, PC
        • Contact:
          • Use Central Contact
      • Tupelo, Mississippi, United States, 38801
        • Recruiting
        • - Nephrology and Hypertension Associates Ltd
        • Contact:
          • Use Central Contact
    • Missouri
      • Kansas City, Missouri, United States, 64128
        • Recruiting
        • Kansas City VA Medical Center
      • Kansas City, Missouri, United States, 64111
        • Recruiting
        • Clinical Research Consultants
        • Contact:
          • Use Central Contact
      • Kansas City, Missouri, United States, 64131
        • Recruiting
        • DCI-Rockhill
        • Contact:
          • Use Central Contact
    • Nebraska
      • Lincoln, Nebraska, United States, 68510
        • Recruiting
        • GSR Enterprises, Inc.
        • Contact:
          • Use Central Contact
      • North Platte, Nebraska, United States, 69101
        • Recruiting
        • Great Plains Health - Nephrology
        • Contact:
          • Use Central Contact
    • Nevada
      • Henderson, Nevada, United States, 89074
        • Recruiting
        • DaVita Clinical Research - Henderson
        • Contact:
          • Use Central Contact
      • Las Vegas, Nevada, United States, 89106
        • Recruiting
        • Kidney Specialists of Southern Nevada
        • Contact:
          • Use Central Contact
      • Reno, Nevada, United States, 89511
        • Recruiting
        • Sierra Nevada Specialty Care
        • Contact:
          • Use Central Contact
    • New Hampshire
      • Portsmouth, New Hampshire, United States, 03801
        • Recruiting
        • Seacoast Kidney and Hypertension Specialists
        • Contact:
          • Use Central Contact
    • New Jersey
      • Eatontown, New Jersey, United States, 07724
        • Recruiting
        • Hypertension & Nephrology Association
        • Contact:
          • Use Central Contact
      • Jersey City, New Jersey, United States, 07305
        • Recruiting
        • New Jersey Kidney Care
        • Contact:
          • Use Central Contact
    • New Mexico
      • Gallup, New Mexico, United States, 87301
        • Recruiting
        • U.S. Renal Care - Gallup
    • New York
      • Albany, New York, United States, 12208
        • Recruiting
        • Albany Medical College Committee of Research Involving Human Subjects
      • Brooklyn, New York, United States, 11203
        • Recruiting
        • SUNY Downstate Medical Center Brooklyn
      • College Point, New York, United States, 11356
        • Recruiting
        • Mattoo & Bhat Medical Associates, P.C.
        • Contact:
          • Use Central Contact
      • Mineola, New York, United States, 11501
        • Recruiting
        • NYU Langone Hospital - Long Island
        • Contact:
          • Use Central Contact
      • The Bronx, New York, United States, 10468
        • Recruiting
        • James J Peters VA Medical Center
      • The Bronx, New York, United States, 10467
        • Recruiting
        • Albert Einstein College Of Medicine - Montefiore Medical Center
        • Contact:
          • Use Central Contact
      • The Bronx, New York, United States, 10461
        • Completed
        • DaVita Clinic Research Bronx
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Recruiting
        • Metrolina Nephrology Associates, PA
        • Contact:
          • Use Central Contact
      • Durham, North Carolina, United States, 27704
        • Recruiting
        • Durham Nephrology Associates, PA
        • Contact:
          • Use Central Contact
      • Durham, North Carolina, United States, 27705
        • Recruiting
        • Duke Translational Medicine Institute
      • Greenville, North Carolina, United States, 27858
        • Recruiting
        • East Carolina University
        • Contact:
          • Use Central Contact
      • Kinston, North Carolina, United States, 28504
        • Recruiting
        • Eastern Nephrology Associates, PLLC
      • Raleigh, North Carolina, United States, 27610
        • Recruiting
        • North Carolina Nephrology, PA
        • Contact:
          • Use Central Location
      • Shelby, North Carolina, United States, 28150
        • Recruiting
        • Nephrology Associates of the Carolinas
    • Ohio
      • Columbus, Ohio, United States, 43215
        • Recruiting
        • HNC Dialysis, Ltd.
        • Contact:
          • Use Central Contact
    • Pennsylvania
      • Bethlehem, Pennsylvania, United States, 18017
        • Recruiting
        • Northeast Clinical Research Center, LLC
        • Contact:
          • Use Central Contact
      • Exton, Pennsylvania, United States, 19341
        • Recruiting
        • Clinical Renal Associates, LTD
    • Rhode Island
      • East Providence, Rhode Island, United States, 02915
        • Recruiting
        • Lifespan Clinical Research
    • South Carolina
      • Columbia, South Carolina, United States, 29203
        • Recruiting
        • Columbia Nephrology
        • Contact:
          • Use Central Contact
      • Spartanburg, South Carolina, United States, 29301
        • Recruiting
        • Dialysis Clinic, Inc.
        • Contact:
          • Trial Information Contact
      • Spartanburg, South Carolina, United States, 29306
        • Recruiting
        • Davita Clinical Research
        • Contact:
          • Use Central Contact
    • Tennessee
      • Chattanooga, Tennessee, United States, 37404
        • Recruiting
        • Southeast Renal Research Institute
        • Contact:
      • Knoxville, Tennessee, United States, 37923
        • Recruiting
        • Knoxville Kidney Center PLLC
        • Contact:
          • Use Central Contact
      • Knoxville, Tennessee, United States, 37920
        • Recruiting
        • Dialysis Clinic Inc - University Nephology
        • Contact:
          • Use Central Contact
      • Memphis, Tennessee, United States, 38105
        • Recruiting
        • Lt. Col. Luke Weathers, Jr. VA Medical Center
      • Nashville, Tennessee, United States, 37232
        • Recruiting
        • Vanderbilt University Medical Center
    • Texas
      • Austin, Texas, United States, 78758
        • Recruiting
        • Research Management, Inc.
        • Contact:
          • Use Central Contact
      • Austin, Texas, United States, 78751
        • Recruiting
        • Cussimanio Research Group LLC
        • Contact:
          • Use Central Contact
      • Beaumont, Texas, United States, 77701
        • Recruiting
        • MW Clinical Research Center
        • Contact:
          • Use Central Contact
      • Dallas, Texas, United States, 75216
        • Recruiting
        • Dallas V.A. Medical Center
      • Dallas, Texas, United States, 75234
        • Recruiting
        • Dallas Nephrology Associates
      • Dallas, Texas, United States, 75237
        • Recruiting
        • US Renal Care
        • Contact:
          • Use Central Contact
      • El Paso, Texas, United States, 79925
        • Recruiting
        • Davita Clinical Research
        • Contact:
          • Use Central Contact
      • El Paso, Texas, United States, 79935
        • Recruiting
        • DaVita Clinical Research - Horizon
        • Contact:
          • Use Central Contact
      • Fort Worth, Texas, United States, 76110
        • Recruiting
        • Fort Worth Renal Group
        • Contact:
          • Use Central Contact
      • Houston, Texas, United States, 77030
        • Recruiting
        • Clinical Research Strategies
        • Contact:
          • Trial Information Contact
      • Houston, Texas, United States, 77099
        • Recruiting
        • Southwest Houston Research
        • Contact:
          • Use Central Contact
      • Houston, Texas, United States, 77074
        • Recruiting
        • Houston Medical Research Institute, LLC
        • Contact:
          • Use Central Contact
      • Houston, Texas, United States, 77070
        • Recruiting
        • Gulf Coast Clinical Research
      • Houston, Texas, United States, 77058
        • Recruiting
        • Aqua Research Institute
        • Contact:
          • Use Central Contact
      • Houston, Texas, United States, 77054
        • Recruiting
        • Davita Clinical Research
        • Contact:
          • Use Central Contact
      • Houston, Texas, United States, 77090
        • Recruiting
        • Clinical Research Strategies, Inc.
        • Contact:
          • Use Central Contact
      • Laredo, Texas, United States, 78041
        • Recruiting
        • Laguna Clinical Research Associates, LLC
        • Contact:
          • Trial Information Contact
      • Mansfield, Texas, United States, 76063
        • Recruiting
        • Prime Clinical Research, Inc.
        • Contact:
          • Use Central Contact
      • McAllen, Texas, United States, 78503
        • Recruiting
        • Gamma Medical Research, Inc.
        • Contact:
          • Use Central Location
      • San Antonio, Texas, United States, 78251
        • Recruiting
        • Davita Clinical Research
        • Contact:
          • Use Central Contact
      • San Antonio, Texas, United States, 78204
        • Recruiting
        • National Institute of Clinical Research, Inc.
        • Contact:
          • Use Central Contact
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • Davita Clinical Research
        • Contact:
          • Use Central Contact
      • San Antonio, Texas, United States, 78258
        • Recruiting
        • DCR-San Antonio Stone Oak
        • Contact:
          • Use Central Contact
      • Shenandoah, Texas, United States, 77384
        • Recruiting
        • DaVita Clinical Research North Houston
        • Contact:
          • Use Central Contact
      • Sherman, Texas, United States, 75092
        • Recruiting
        • Medrasa Clinical Research
        • Contact:
          • Trial Information Contact
      • The Woodlands, Texas, United States, 77384
        • Recruiting
        • Renal Research of Montgomery County
        • Contact:
          • Trial Information Contact
    • Virginia
      • Chesapeake, Virginia, United States, 23320
        • Recruiting
        • DCR-Norfolk Great Bridge
        • Contact:
      • Fairfax, Virginia, United States, 22033
        • Recruiting
        • Nephrology Associates of Northern Virginia Inc
        • Contact:
      • Hampton, Virginia, United States, 23666
        • Recruiting
        • Peninsula Kidney Associates
        • Contact:
      • Norfolk, Virginia, United States, 23502
    • West Virginia
      • Bluefield, West Virginia, United States, 24701
        • Recruiting
        • Nephrology and Hypertension Associates
        • Contact:
          • Use Central Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Male or female at least 18 years of age.
  • A diagnosis of ESKD undergoing maintenance dialysis for at least 12 weeks.
  • Serum hs-CRP ≥ 2.0 mg/L.
  • A diagnosis of diabetes mellitus OR ASCVD.

Exclusion Criteria:

  • Subjects who participated in Part 1 (phase 2b) are not eligible to participate in Part 2 (phase 3).
  • Concomitant use of systemic immunosuppressant drugs.
  • Abnormal LFTs.
  • Any life-threatening disease expected to result in death within 12 months.
  • A history of GI perforation, inflammatory bowel disease (except fully excised. ulcerative colitis), or peptic ulcer disease.
  • Clinically significant active infection or history of opportunistic or invasive fungal infection.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: CSL300 (low dose)(Phase 2b)
Intravenous (IV) administration
IV administration
Other Names:
  • Clazakizumab
Experimental: CSL300 (medium dose)(Phase 2b)
IV administration
IV administration
Other Names:
  • Clazakizumab
Experimental: CSL300 (high dose)(Phase 2b)
IV administration
IV administration
Other Names:
  • Clazakizumab
Placebo Comparator: Placebo (Phase 2b)
IV administration
Matching the excipient content and concentration of the CSL300 product, minus the active ingredient.
Experimental: CSL300 (Phase 3)
IV administration
IV administration
Other Names:
  • Clazakizumab
Placebo Comparator: Placebo (Phase 3)
IV administration
Matching the excipient content and concentration of the CSL300 product, minus the active ingredient.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change from Baseline on the log scale in high-sensitivity C-reactive protein (hs-CRP)(Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Time to first occurrence of CV death or myocardial infarction (MI) (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Area under the plasma concentration versus time curve (AUC) for CSL300 (Phase 2b)
Time Frame: Up to 24 weeks
Up to 24 weeks
Peak Plasma Concentration (Cmax) for CSL300 (Phase 2b)
Time Frame: Up to 24 weeks
Up to 24 weeks
Trough Plasma Concentration (Ctrough) for CSL300 (Phase 2b)
Time Frame: Up to 24 weeks
Up to 24 weeks
Time to Maximum Plasma Concentration (Tmax) for CSL300 (Phase 2b)
Time Frame: Up to 24 weeks
Up to 24 weeks
Mean change from Baseline in neutrophils (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Mean change from Baseline in platelets (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Mean change from Baseline in total bilirubin (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Titer of confirmed antibodies specific to CSL300 (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Time to first occurrence of all-cause death or MI (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Time to first occurrence of CV death, MI, or ischemic stroke (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Time to first occurrence of CV death (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Time to first occurrence of CV death, MI or major adverse limb event (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Time to first occurrence of all-cause death (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Total number of CV hospitalizations (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Total number of HF hospitalizations and urgent visits (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Total number of hospitalizations (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years
Percent of participants achieving hs-CRP less than (<) 2.0 milligram per Liter (mg/L) (Phase 2b)
Time Frame: Week 12
Week 12
Change from baseline in log-transformed hs-CRP (Phase 2b)
Time Frame: Baseline and up to 24 weeks
Baseline and up to 24 weeks
Mean change from Baseline in serum amyloid A (SAA) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in secretory phospholipase A2 (sPLA2) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in fibrinogen (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in plasminogen activator inhibitor -1 (PAI-1) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in lipoprotein (Lp) (a) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in albumin (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in Hepcidin (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in hemoglobin (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in erythropoiesis-stimulating agents (ESA) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in erythropoietin-resistance index (ERI) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in iron (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in total iron binding capacity (TIBC) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in transferrin saturation (TSAT) (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Mean change from Baseline in ferritin (Phase 2b)
Time Frame: Baseline and up to 12 weeks
Baseline and up to 12 weeks
Percent of participants with adverse events (AE), serious AE (SAE), including adverse events of special interest (AESIs) (Phase 2b)
Time Frame: Up to 32 weeks
Up to 32 weeks
Mean change from Baseline in white blood cell (WBC) (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Mean change from Baseline in aspartate aminotransferase (AST) (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Mean change from Baseline in alanine aminotransferase (ALT) (Phase 2b)
Time Frame: Up to 12 weeks
Up to 12 weeks
Mean change from Baseline in lipid panel (Phase 2b)
Time Frame: Up to 12 weeks
Lipid panel consists of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride.
Up to 12 weeks
Time to first occurrence of CV death, MI, or hospitalization for heart failure (HF) (Phase 3)
Time Frame: Approximately 5 years
Approximately 5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Investigators

  • Study Director: Study Director, CSL Behring LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 21, 2022

Primary Completion (Estimated)

May 22, 2029

Study Completion (Estimated)

May 22, 2029

Study Registration Dates

First Submitted

July 29, 2022

First Submitted That Met QC Criteria

August 1, 2022

First Posted (Actual)

August 3, 2022

Study Record Updates

Last Update Posted (Actual)

June 2, 2026

Last Update Submitted That Met QC Criteria

May 29, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

CSL will consider on a case-by-case basis requests to share Individual Patient Data (IPD) with external bona-fide, qualified scientific and medical researchers. For information on the process and requirements for submitting a voluntary data sharing request for IPD, please contact CSL at clinicaltrials@cslbehring.com.

IPD Sharing Time Frame

Requests for IPD will generally be considered once review by major regulatory authorities (ie FDA, EMA) is complete and the primary publication is available.

IPD Sharing Access Criteria

Proposed research should seek to answer a previously unanswered important medical or scientific question.

Applicable country specific privacy and other laws and regulations will be considered and may prevent sharing of IPD.

If the request is approved and the researcher has executed an appropriate data sharing agreement, IPD that has been appropriately anonymized will be available.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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