Validity and Reproducibility of Dietary Assessment Against Objective Measures (VALID)

Validity and Reproducibility of A Self-administered Web-based 24-hour Dietary Assessment Tool Among Danish Adults Against Objective Measures

A cross-sectional study with repeated measurements among healthy Danish adults to assess the validity and reproducibility of a self-administered 7-day web-based dietary assessment tool, myfood24® tested against objective biomarkers.

Study Overview

• Status: Completed
• Conditions: Validation Study

Detailed Description

Healthy volunteers (age 35-70 yrs; BMI 22-32) will be recruited for the study. Informed consent will be obtained and participants will complete a self-administered web-based 7-day 24-hour dietary recall tool (myfood24®).Validity of this dietary registration tool will be assessed by comparing the estimated intake of selected nutrients (protein, energy) and selected food groups (fruit and vegetables, whole grain, coffee, alcoholic beverages) against objective biomarkers obtained from a 24-hour urine sample, through a measurement of resting energy metabolic rate, and from a fasting blood sample, respectively. Reproducibility will be assessed by comparison of the results from two self-administered web-based 7-day 24-hour dietary recalls obtained 4 weeks (± 1 weeks) apart.

• Study Type: Observational
• Enrollment (Actual): 70

Contacts and Locations

Study Locations

• Denmark
  • DK
    • Frederiksberg, DK, Denmark, 1958
      • University of Copenhagen

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 35 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Healthy Danish adults

Description

Inclusion criteria:

• Apparently healthy adults between 35 and 70 years old
• Body mass index (BMI) between 22-32 kg/m2
• Weight stable defined as gain or loss of < 2.5% body weight during the past 3 months;
• Willingness to maintain current dietary and physical activity habits throughout the study period.
• Have high-speed internet access;
• Able to speak, read and write Danish;
• Willing to visit the Department of Nutrition, Exercise, and Sports (NEXS).

Exclusion Criteria:

• Clinically diagnosed chronic disease,
• use of corticosteroids or other medication that would potentially affect the nutrient metabolism or excretion of biomarkers of interest,
• presence of food allergy or intolerance that requires a special diet,
• pregnancy and lactation,
• excess physical activity (>5h/week of high intensity),
• current participation in another trial

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Validation of protein intake	Agreement between mean protein intake per day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and nitrogen excretion in a 24-hr urine sample (urea corrected for creatine).	7 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Validation of energy intake	Agreement between mean energy intake per day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and resting metabolic rate (measured by ventilated hood).	7 days
Validation of vegetable and fruit intake	Agreement between mean intake of vegetable and fruit per day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and concentration of folate in a fasting blood sample.	7 days
Validation of whole grain intake	Agreement between intake of whole grain per day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and excretion of alkylresorcinols in a fasting blood sample.	7 days
Validation of alcohol intake	Agreement between mean alcohol intake pr day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and excretion of ethanol and ethyl conjugates in a 24-hr urine sample.	7 days
Validation of coffee intake	Agreement between mean coffee intake per day assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) and excretion of trigonelline and cyclo(isoleucylprolyl) in a 24-hr urine sample.	7 days
Reproducibility of dietary registration	Agreement between two dietary intake measurements assessed by the self-administered 7-day web-based dietary assessment tool (myfood24) obtained 4 (± 1 week) apart.	Two times 4 weeks (+/- 1 week) apart

Collaborators and Investigators

• Sponsor: Inge Tetens
• Investigators: Principal Investigator: Inge Tetens, PhD, Professor

Study record dates

Study Major Dates

• Study Start (Actual): October 31, 2022
• Primary Completion (Actual): August 25, 2023
• Study Completion (Actual): August 25, 2023

Study Registration Dates

• First Submitted: October 12, 2022
• First Submitted That Met QC Criteria: October 26, 2022
• First Posted (Actual): October 31, 2022

Study Record Updates

• Last Update Posted (Actual): October 6, 2023
• Last Update Submitted That Met QC Criteria: October 5, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: M243

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No