- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05626166
the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis
Clinical Study Evaluating the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis Treated With Mesalamine
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This study aims at evaluating the efficacy and safety of diosmin as add-on therapy to mesalamine in patients with mild to moderate ulcerative colitis.
This proof of concept study will be designed to be a randomized, double-blind, placebo controlled parallel study. The study will be conducted on 60 patients with mild to moderate ulcerative colitis receiving mesalamine. The patient will be followed for 3 months.
The patients will be randomised into the following two groups:
Group I (Control group; n=30) which will receive mesalamine 1000 mg three times daily plus placebo tablets twice daily for 3 months.
Group II: (Diosmin group; n=30) which will receive mesalamine 1000 mg three times daily plus diosmin 600 mg twice daily for 3 months.
All participants included in this study will be subjected to the following:
- Demography, history, and physical examination
- Blood sample collection and biochemical assessment At baseline and after the intervention, 10 ml of venous blood will be withdrawn from each participant.
3 ml of blood will be used for immediate determination of routine parameters including:
- Hemoglobin concentration.
- Ertherythrocyte sedimentation rate (ESR).
- Prothrombin time.
Two ml of blood will be immediately centrifuged at 3000 rpm for 10 min for immediate determination of:
- Serum albumin
The remaining 5 ml of blood will be used for the analysis of the biological parameters which include:
- Malondialdehyde (MDA) as oxidative stress marker (colorimetry).
- Tumor necrosis factor-alpha (TNF-α) as pro inflammatory marker (ELISA).
- Caspase-3 as a potential marker for apoptosis (ELISA). 3. Clinical assessment
Clinical assessment will be done through determination of:
A. Disease severity which will be assessed according to the modified Truelove and Witt's classification.
B. The activity index (AI) for ulcerative colitis which is expressed as follows:
AI = 60 x blood stool + 13 x bowel movements (frequency of defection) + 0.5 x ESR - 4 x Hb - 15 x albumin + 200.
C. Health-related Quality of Life (HRQoL) using The Short Inflammatory Bowel Disease Questionnaire (SIBDQ).
D. Assessement of pain score through the brief pain inventory short form "BPI-SF" worst item.
Study Type
Enrollment (Anticipated)
Phase
- Phase 3
Contacts and Locations
Study Locations
-
-
-
Tanta, Egypt
- Recruiting
- Tanta University Hospital
-
Contact:
- Tanta University Hospitals
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Age ≥18 years old.
- Both male and female sex.
- Newly diagnosed patients with mild and moderate ulcerative colitis and treated with 5-aminosalicylic acid (mesalamine).
Exclusion Criteria:
- Patients with severe ulcerative colitis.
- Patients with colorectal cancer.
- Patients on rectal or systemic steroids.
- Patients on immunosuppressants or biological therapies.
- Patients with previously failed treatment with sulphasalazine.
- Patients with known allergy to study medications.
- History of complete or partial colectomy.
- Patients with heart diseases and arrhythmia.
- Patients on blood thinning agents.
- Patients on anticoagulants (warfarin), anticonvulsants (carbamazepine and phenytoin), muscle relaxants (chlorzoxazone) and non-steroidal anti-inflammatory drugs (diclofenac).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: control group
Group I (Control group; n=30) which will receive mesalamine 1000 mg three times daily plus placebo tablets twice daily for 3 months.
|
placebo tablets twice daily
|
Experimental: diosmin group
Group II: (Diosmin group; n=30) which will receive mesalamine 1000 mg three times daily plus diosmin 600 mg twice daily for 3 months.
|
diosmin 600 mg twice daily
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
the change in Truelove and Witt's classification.
Time Frame: at baseline then after 3 months
|
at baseline then after 3 months
|
the change in health related quality of life (HRQoL) questionnaire
Time Frame: at baseline then after 3 months
|
at baseline then after 3 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
the change in the measured biological parameters (TNF alpha, MDA, caspase-3)
Time Frame: at baseline then after 3 months
|
at baseline then after 3 months
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 36031/11/22
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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