Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients

May 21, 2023 updated by: Xin Guo
The investigators continuously collected data from 482 AIS inpatients at the Neurology Department of Hebei General Hospital. Both demographic and clinical data were collected from the study subjects. Different head magnetic resonance imaging sequences were used to assess the subjects' CMBs, white matter lesions, and old lacunar infarcts (LI). Various statistical methods, including the t-test, χ2 test, and logistic regression, were used to analyze the gender heterogeneity of the influencing factors for CMBs in AIS patients.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

482

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

In this study, the data of patients with AIS who were admitted to the Department of Neurology of Hebei Provincial People's Hospital from January 2014 to December 2015 were continuously collected.

Description

Inclusion Criteria:

  • Aged 18 years and older
  • Must meet the diagnostic criteria for AIS as presented in the Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2014
  • Must be in good physical condition and have the ability to cooperate with MRI examinations
  • Must have underwent SWI

Exclusion Criteria:

  • MRI contraindications present, such as cardiac pacemaker, cardiac stents, or metal implants
  • Head MRI or carotid artery ultrasound suggests the presence of severe stenosis or occlusion in the intracranial or extracranial segments of the cerebral arteries
  • Severe comorbid diseases, such as cardiac, pulmonary, hepatic, and renal insufficiencies

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Comparison of clinical data between AIS patients in CMB and non-CMB groups
without CMBs; with CMBs
Other: cerebral microbleeds
Whether patients with acute ischemic stroke are complicated by cerebral microbleeds
male; female
Other: cerebral microbleeds
Whether patients with acute ischemic stroke are complicated by cerebral microbleeds

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Comparison of clinical data between AIS patients in CMB and non-CMB groups
Time Frame: from January 2014 to December 2015
Differences in general information between AIS patients in CMB and non-CMB groups
from January 2014 to December 2015
Comparison of clinical data between male and female AIS patients
Time Frame: from January 2014 to December 2015
Differences in general informationbetween male and female AIS patients
from January 2014 to December 2015
Comparison of CMB-related characteristics between the male and female AIS patients
Time Frame: from January 2014 to December 2015
Differences in CMB-related characteristics between the male and female AIS patients
from January 2014 to December 2015
Predictive factor analysis for CMBs in male AIS patients
Time Frame: from January 2014 to December 2015
CMB-related factors in male AIS patients
from January 2014 to December 2015
Predictive factor analysis for CMBs in female AIS patients
Time Frame: from January 2014 to December 2015
CMB-related factors in female AIS patients
from January 2014 to December 2015

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Xin Guo

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2014

Primary Completion (Actual)

December 1, 2015

Study Completion (Actual)

December 1, 2015

Study Registration Dates

First Submitted

May 11, 2023

First Submitted That Met QC Criteria

May 21, 2023

First Posted (Actual)

May 31, 2023

Study Record Updates

Last Update Posted (Actual)

May 31, 2023

Last Update Submitted That Met QC Criteria

May 21, 2023

Last Verified

May 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20220642

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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