Antibiotic Regimen for Dental Implants Cases

June 8, 2023 updated by: Salma Mohamed Essam El-din Osman, Assiut University

Antibiotic Regimen for Patients Seeking Dental Implants Procedures

This study aims to:

  1. To identify the most common organisms causing dental implant failure.
  2. Set an appropriate antibiotic regimen according to the causative organism to limit the antimicrobial resistance by limit the use of antibiotics.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

Dental implant surgery is a common treatment for replacing missing teeth and has a high success rate. Implant failure is most likely the result of multiple factors as Age, sex, smoking, maxillary implant site, quantity and quality of bone, implant surface treatments and features are some of the statistically examined parameters linked to implant failure. The most frequent and avoidable cause of dental implant failure is infection. A retrospective analysis demonstrated fewer numbers of early implant failures among those that were placed under antibiotic treatments.

Early implant failure is commonly associated with certain strains of bacteria. The most common bacteria involved are streptococci, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods.Porphyromonas gingivalis and Fusobacterium nucleatum frequently colonize the implant in early and late losses and could therefore be characteristic for implant loss in general.

Thus, the antibiotic to prevent delayed healing of wound should be bactericidal and of low toxicity. Systemic antibiotic prophylaxis has been used to reduce the risk of early implant failure and local infections around dental implants.Antibiotics are one of the most cost-effective, life-saving medicines and contribute to an extended lifespan. Access to antibiotics without a prescription is a driving factor for irrational antibiotic use due to a potential lack of access to proper diagnosis and diagnostic tools. This eventually leads to the development and spread of antibiotic resistance &it is one of the increasing public health challenges worldwide.

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

patients seeking dental implant procedures

Description

Inclusion Criteria: Saliva samples from patients seeking dental implant procedures

-

Exclusion Criteria:

  • Immunodeficiency or immunosuppressing treatment
  • current antibiotic treatment
  • smoking
  • acute or chronic oral infection (including ongoing periodontal infection).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
to limit the antimicrobial resistance by identifying the most suitable antibiotic regimen according to the intra-oral organisms
Time Frame: september 2023-september 2024
according to the antibiogram at least 30 isolates from each species are needed to identify the most common organisms and set an appropriate antibiotic regimen for patients seeking dental implants.An antibiogram is an overall profile of antimicrobial susceptibility testing results of a specific microorganism to a battery of antimicrobial drugs. This profile is generated by the laboratory using aggregate data from a hospital or healthcare system; data are summarized periodically and presented showing percentages of organisms tested that are susceptible to a particular antimicrobial drug
september 2023-september 2024

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
to prevent dental implant failure by setting the most suitable antibiotic regimen according to the intra-oral micro-organisms
Time Frame: through the study completion, an average of one year.
the investigator can define and set antibiotic regimen to the oral micro-organisms by the antibiogram .The Clinical and Laboratory Standards Institute (CLSI; formerly NCCLS) published guidelines entitled "Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data" for use when creating an antibiogram. CLSI guidelines recommend compiling the antibiogram at least annually, including only the first isolate per patient in the period analyzed, and including only organisms for which ≥30 isolates were tested in the period analyzed.
through the study completion, an average of one year.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 15, 2023

Primary Completion (Estimated)

September 15, 2024

Study Completion (Estimated)

October 20, 2024

Study Registration Dates

First Submitted

May 27, 2023

First Submitted That Met QC Criteria

June 8, 2023

First Posted (Actual)

June 12, 2023

Study Record Updates

Last Update Posted (Actual)

June 12, 2023

Last Update Submitted That Met QC Criteria

June 8, 2023

Last Verified

June 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

  • antibiotic for dental implants

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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