Resistance Training in Children

The Effects of Resistance Training on Muscle Lipids in Children.

The project is going to examine the effects of resistance exercise training in prepubescent youth on skeletal muscle strength and lipid content.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Resistance exercise training

• Study Type: Interventional
• Enrollment (Actual): 3
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Kansas
    • Kansas City, Kansas, United States, 66103
      • Hoglund Biomedical Imaging Center
    • Overland Park, Kansas, United States, 66213
      • Exercise and Human Performance Laboratory
    • Overland Park, Kansas, United States, 66213
      • Metabolic and Body Composition Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy volunteer males and females ages 8 - 10 years.

Exclusion Criteria:

• No history or ongoing neuromuscular diseases.
• No history or ongoing musculoskeletal injuries.
• No history or ongoing disease that effects metabolism.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control; Participants do not perform resistance exercise training.
Experimental: Resistance exercise training; Participants undergo 24 sessions of resistance exercise training over about 8 weeks.	Other: Resistance exercise training; Participants will strength train via linear periodization resistance exercise training.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in the muscular strength of leg extensors, as measured with isotonic strength.	The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength.	baseline, following the intervention (9 weeks)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in thigh muscle cross-sectional area.	Scores are measured cross-sectional area from ultrasound images. The higher score, reflects greater muscle size of the leg extensors.	baseline, following the intervention (9 weeks)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)
Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)

Collaborators and Investigators

• Sponsor: University of Kansas Medical Center
• Collaborators: National Strength and Conditioning Association Foundation

Study record dates

Study Major Dates

• Study Start (Actual): May 30, 2023
• Primary Completion (Actual): October 14, 2023
• Study Completion (Actual): October 14, 2023

Study Registration Dates

• First Submitted: October 17, 2023
• First Submitted That Met QC Criteria: October 17, 2023
• First Posted (Actual): October 24, 2023

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 10, 2024
• Last Verified: December 1, 2024

More Information

Terms related to this study

• Keywords: exercise; strength; intramyocellular lipids; muscle cross-sectional area; extramyocellular lipids
• Other Study ID Numbers: STUDY0014990

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No