Occupational Exposures Among Firefighters

November 12, 2024 updated by: Vincere Cancer Center

Effect of Occupational Exposures on Cancer Pathophysiology Among Firefighters

This study aims to understand the effect of occupational exposures, including PFAS exposures, among firefighters.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • United States
    • Arizona
      • Scottsdale, Arizona, United States, 85260
        • Recruiting
        • Vincere Cancer Center
        • Contact:
        • Contact:
          • Vershalee Shukla, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Actively working or retired firefighters of any adult age, any gender and any demographic group are eligible, with no limitations regarding general health status other than those specified in the protocol Eligibility Criteria.

Description

Inclusion Criteria:

  • 18 years of age or older; any gender
  • Currently (or previously) employed as a firefighter, full-time or part-time, participating in Vincere's First Responder Cancer Screening Program
  • Willing to provide a blood, urine, and/or tissue sample
  • Able to provide informed consent to participate in the study

(A small group of non-firefighters will be enrolled to act as a comparison group)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Firefighters
Other: PFAS / heavy metal testing, exposures
PFAS / heavy metal concentrations, exposure survey
Non-Firefighters
Other: PFAS / heavy metal testing, exposures
PFAS / heavy metal concentrations, exposure survey

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Exposures associated with elevated PFAS
Time Frame: 5 years
5 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Cancer rates
Time Frame: 5 years
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Vincere Cancer Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 6, 2023

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2029

Study Registration Dates

First Submitted

December 7, 2023

First Submitted That Met QC Criteria

December 7, 2023

First Posted (Actual)

December 18, 2023

Study Record Updates

Last Update Posted (Estimated)

November 14, 2024

Last Update Submitted That Met QC Criteria

November 12, 2024

Last Verified

November 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • VCC-PFAS-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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