A Study to Compare the Pharmacokinetics and Safety of QL1101 and EU-Avastin® in Healthy Volunteers

A Randomized, Double-blind, Single-dose, Parallel-group Study to Compare the Pharmacokinetics and Safety of QL1101 and EU-Avastin® in Healthy Volunteers

The goal of this clinical trial is to compare the pharmacokinetic and safety similarity of QL1101 with EU-Avastin® in healthy male volunteers.

Participants will receive a single injection of QL1101/ EU-Avastin®.Researchers will compare pharmacokinetic, safety, and immunogenic similarities between the 2 groups.

Study Overview

• Status: Completed
• Conditions: Tumor
• Intervention / Treatment: Drug: QL1101; Drug: Avastin®

Detailed Description

This is a phase I,single center, randomized, double-blind and parallel group clinical trial .

The primary objective is to assess the pharmacokinetic similarity of single injections of QL1101 or EU-Avastin® in healthy volunteers.

The secondary objective are to assess the clinical safety and immunogenicity similarity of single injections of QL1101 or EU-Avastin® in healthy volunteers.

Subjects would receive a single 100mg（4ml） of QL1101or EU-Avastin® injection.

• Study Type: Interventional
• Enrollment (Actual): 84
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Jilin
    • Changchun, Jilin, China, 130000
      • The first Affiliated Hospital of Jilin University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Subjects who voluntarily sign the written ICF;
2. Males aged 18- 50 years(inclusive).
3. Body weight between 50.0 kg and 90.0 kg (inclusive), body mass index (BMI) between 18.0 kg/m2 and 28.0 kg/m2 (inclusive);
4. Subjects who agree to practice effective contraception (including but not limited to physical contraception, surgery, or abstinence) throughout the study period until at least 6 months after study drug administration; See Appendix 3 for details;
5. Subjects with no disease history or with a previous medical history which is not clinically significant or has no influence on the study as determined by the study doctor.

Exclusion Criteria:

1. Subjects who have previously suffered or are currently suffering from any clinically significant diseases such as circulatory system, endocrine system, nervous system, digestive system, respiratory system, genitourinary system, haematology, immunology and metabolic abnormalities or any other diseases that can interfere with the test results;
2. Abnormalities in clinical laboratory tests, preoperative infectious markers, Chest X-ray, 12-lead ECG, physical examination, vital signs, Abdominal ultrasound were clinically significant or judged to have an impact on the study (based on the judgment of the clinical study doctor);
3. History of hereditary bleeding, thrombophilia, thrombosis (eg, cerebral thrombosis, arteriovenous thrombosis), or history of non-traumatic bleeding and appropriate treatment, or any other condition that may predispose the subject to increased risk of bleeding or thrombosis (eg, thrombocytopenia, or INR > 1.5, etc.);
4. Hypersensitivity to the investigational products or any component of the investigational products, history of specific allergy (Recurrent asthma, urticaria, eczema, etc.) or allergic constitution (such as two or more drugs, food such as milk and pollen allergy);
5. Subjects with a history of gastrointestinal perforation, gastrointestinal fistula or any fistula or inflammatory bowel disease;
6. Recent infection requiring systemic anti-infective treatment within 28 days or serious infection (hospitalization and/or requiring intravenous antibiotics) within 6 months before administration of investigational product;
7. Subjects who have received surgical operation or bone fracture within 4 weeks before screening, or plan to receive surgical operation during the study;
8. One of the HBsAg, hepatitis C antibody, HIV antibody or Treponema pallidum antibody were tested positive;
9. Subjects who have taken any medicine or healthcare product (including Chinese herbal medicine) within 14 days before administration of investigational product;
10. Subjects who have received any biological products or live virus vaccines within 3 months or monoclonal antibodies within 9 months before the study treatment, or bevacizumab or VEGF targeted agents (such as aflibercept, ranibizumab, Conbercept, etc.) before administration of investigational product;
11. Subjects who have participated in the clinical study and administered the investigational product within 3 months before administration of investigational product;
12. Blood donors within 3 months before administration of investigational product;
13. Excessive consumption of tea, coffee and/or caffeinated beverages (more than 8 cups, 1 cup = 250 mL) per day;
14. Subjects who are addicted to smoking or smoke more than 5 cigarettes per day in the 3 months before screening;
15. Alcoholics or regular drinkers within 6 months before screening, defined as drinking more than 14 units of alcohol per week (1 unit = 285 mL of beer, or 25 mL of spirits, or 100 mL of wine);
16. Drug abusers or those who have used soft drugs (such as marijuana) 3 months before screening or hard drugs (such as cocaine, phencyclidine, etc.) 1 year before screening;
17. Urine drug screening and breath test for alcohol was tested positive before administration of investigational product;
18. Subjects who may not be able to complete this study for other reasons or should not be included in the investigator's opinion.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: QL1101; QL1101, intravenous infusion 90 min (±5min), D1 (Day 1, single dose)	Drug: QL1101; 3mg/kg, single intravenous infusion over 90 min (± 5 min) on first day
Active Comparator: Avastin®; Avastin®, intravenous infusion 90 min (±5min), D1 (Day 1, single dose)	Drug: Avastin®; 3mg/kg, single intravenous infusion over 90 min (± 5 min) on first day

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
AUC0-∞	To evaluate pharmacokinetic similarity between QL1101 and Avastin® after a single intravenous infusion in healthy volunteers	99 day
Cmax	To evaluate pharmacokinetic similarity between QL1101 and Avastin® after a single	99 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
AUC0-t	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
Tmax	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
t1/2	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
CL	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
Vd	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
(AUC0--∞ -AUC0-t)/（AUC0--∞×100%)	To evaluate pharmacokinetic similarity between QL1101 and Avastin®	99 day
the rate of treatment-related adverse events as assessed by NCI CTCAE v5.0	Safety, as defined by the rate of treatment-related adverse events as assessed by NCI CTCAE v5.0.after a single intravenous infusion in healthy volunteers;	99 day
immunogenicity	Immunogenicity will be assessed by the incidence of ADA and Nab.	99 day

Collaborators and Investigators

• Sponsor: Qilu Pharmaceutical Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): June 20, 2024
• Primary Completion (Actual): November 18, 2024
• Study Completion (Actual): November 18, 2024

Study Registration Dates

• First Submitted: January 21, 2024
• First Submitted That Met QC Criteria: January 29, 2024
• First Posted (Actual): January 31, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 13, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Antineoplastic Agents, Immunological; Antineoplastic Agents; Physiological Effects of Drugs; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Growth Substances; Growth Inhibitors; Bevacizumab
• Other Study ID Numbers: QL1101-102

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No