Immune Function of Colorectal Cancer Lymph Nodes

A Multiomics-based Study of the Immune Function of Colorectal Cancer Lymph Nodes

Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.

Study Overview

• Status: Not yet recruiting
• Conditions: Colorectal Cancer; Lymph Node
• Intervention / Treatment: Other

• Study Type: Observational
• Enrollment (Estimated): 500

Contacts and Locations

• Study Contact: Name: Xu Guan; Phone Number: 13141307719; Email: drguanxu@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Probability Sample

Study Population

Stage I-III colorectal cancer patients undergoing radical surgery with complete clinical imaging, pathology, and genetic data.

Description

Inclusion Criteria:

• Stage I-III colorectal cancer patients undergoing radical surgery
• Complete imaging, pathology and genetics multi-omics data available
• 18-75 years old

Exclusion Criteria:

• Patients with preoperative neoadjuvant therapy
• Patients with incomplete clinical information
• Patients with other malignant tumors
• Patients with acute infections or untreated chronic infections

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
negative lymph node
postive lymph node

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics	BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them	2024.04-2026.04
To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics	Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways	2024.04-2026.04
The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics	Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment	2024.04-2026.04

Collaborators and Investigators

• Sponsor: Shanxi Province Cancer Hospital
• Collaborators: Cancer Institute and Hospital, Chinese Academy of Medical Sciences; The Second Affiliated Hospital of Harbin Medical University

Study record dates

Study Major Dates

• Study Start (Estimated): April 1, 2024
• Primary Completion (Estimated): April 1, 2026
• Study Completion (Estimated): April 1, 2026

Study Registration Dates

• First Submitted: January 19, 2024
• First Submitted That Met QC Criteria: March 12, 2024
• First Posted (Actual): March 20, 2024

Study Record Updates

• Last Update Posted (Actual): March 20, 2024
• Last Update Submitted That Met QC Criteria: March 12, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: 2022YFC2505700

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No