Dorsolateral Prefrontal Cortex Transcranial Direct Current and Muscle Fatigue Stimulation on Muscle Fatigue

The Influence of Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation on Muscle Fatigue

The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) can impact muscle fatigue. The main questions it aims to answer are:

1. Does tDCS of the left DLPFC increase the time that a fatiguing contraction can be maintained?
2. Does tDCS of the left DLPFC decrease the rate of increase of muscle activity, force error, and standard deviation of force during a fatiguing contraction.

Researchers will compare tDCS of the left DLPFC to a SHAM stimulation (a type of stimulation that feels like real tDCS but does not elicit physiological effects) to see if tDCS of the left DLPFC works to reduce the progression of muscle fatigue.

Participants will:

Performing two experimental sessions held 3-10 days apart (usually 7 days) Perform a 9 hole pegboard test, maximum voluntary contractions, and a fatiguing contraction.

Study Overview

• Status: Enrolling by invitation
• Conditions: Fatigue
• Intervention / Treatment: Device: transcranial direct current stimulation

Detailed Description

Transcranial direct current stimulation (tDCS) delivered to the dorsolateral prefrontal cortex (DLPFC) can increase endurance time in lower body tasks. Therefore, the purpose of this study is to examine the effect of DLPFC-tDCS on the time to task failure (TTF) of a fatiguing contraction performed by hand muscles. The study will use a double-blind, randomized, SHAM-controlled, crossover design with each participant performing two experimental sessions held 3-7 days apart. The only difference between the two sessions will be the type of stimulation (tDCS or SHAM; counterbalanced) applied concurrent with the fatiguing contraction. The fatiguing contraction will involve gripping a manipulandum with the index finger and thumb. This will be accomplished by using a precision grip and matching an isometric target equal to 15% of the maximum voluntary contraction (MVC) for as long as possible until task failure.

• Study Type: Interventional
• Enrollment (Estimated): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Nevada
    • Las Vegas, Nevada, United States, 89154
      • University of Nevada Las Vegas

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Able to provide informed consent
2. Free from any neurological or psychiatric condition
3. Age between 18-50 years old
4. Right-handed (as determined by the Edinburgh Handedness Inventory)

Exclusion Criteria:

1. An uncontrolled medical condition (i.e. hypertension, diabetes, etc)
2. Metal in the skull or the eye, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, and metal fragments in the eye.
3. Hearing loss diagnosed by a doctor and requiring a hearing aid. Have had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures, have a neurological disorder, a movement disorder, or have a head injury that involved being passed out for more than a few seconds.
4. History of migraines
5. implanted defibrillator or implanted neurostimulator
6. pregnant or thought to be pregnant. This must be an exclusion criterion as there are few medical papers available regarding the effects of tDCS on the unborn child/fetus or expectant mother. Thus, if you are pregnant or thought to be pregnant you cannot participate in the study. If you find out you are pregnant in the week timeframe between experiment 1 and experiment 2, you should withdraw from the study as we cannot perform the second experiment in that case.
7. Not done a similar fatigue study in the laboratory in the last 7 days.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: tDCS; Transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex	Device: transcranial direct current stimulation; Transcranial direct current stimulation is a type of non-invasive brain stimulation that involves passing a weak current between two electrodes placed on the scalp.
Sham Comparator: SHAM; SHAM transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex	Device: transcranial direct current stimulation; Transcranial direct current stimulation is a type of non-invasive brain stimulation that involves passing a weak current between two electrodes placed on the scalp.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to Task Failure	The time in seconds that a fatiguing contraction can be held	5 months
Fatigue Index	The percent decline in force between the maximum voluntary contractions performed before and after the fatiguing contraction	5 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Average EMG activity	The average EMG activity of the first dorsal interosseus muscle during the fatiguing contraction.	5 months
Force error	The average force error during the fatiguing contraction.	5 months
Standard deviation of force	The average standard deviation of force during the fatiguing contraction.	5 months
9 Hole Pegboard Test	9 Hole Pegboard Test time before and after the fatiguing contraction	5 months

Collaborators and Investigators

• Sponsor: University of Nevada, Las Vegas

Study record dates

Study Major Dates

• Study Start (Actual): April 4, 2024
• Primary Completion (Estimated): August 31, 2024
• Study Completion (Estimated): September 30, 2024

Study Registration Dates

• First Submitted: April 24, 2024
• First Submitted That Met QC Criteria: April 24, 2024
• First Posted (Actual): April 29, 2024

Study Record Updates

• Last Update Posted (Actual): April 29, 2024
• Last Update Submitted That Met QC Criteria: April 24, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Fatigue
• Other Study ID Numbers: UNLV-2024-115

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No