Integrative Adolescence Research Programme (IARP) (IARP)

Integrative Adolescence Research Programme (IARP) - iAdoRe Study

This study aims to understand child health during adolescence. We will examine the role of lifestyle (e.g. physical activity), growth trajectories and other environmental factors that can influence the development of phenotypes in adolescence which confer risk for later physical and mental disorders. With this study, we will develop a deeper understanding of adolescent health and well-being and their main determinants in the local Singaporean context, identify levers for early interventions to mitigate challenges to adolescent health and well-being and enhance protective factors for adolescents to do well in life, contribute to society and maximize their potential.

Study Overview

• Status: Recruiting
• Conditions: Mental Health Wellness 1; Executive Dysfunction; Physical Stress
• Intervention / Treatment: Other: No intervention

Detailed Description

The study aims to advance current public policy and health service practices by developing public health, clinical and commercially valuable interventions within the context of expanding commercial partnerships and building multidisciplinary translational research capacity in Singapore. In addition to the early life period (i.e., the first 1,000 days), the adolescent period has been identified as a crucial second window of opportunity to influence human development and improve life-long well-being. Adolescence is a key developmental period for body, brain and socioemotional changes. Puberty is characterised by growth spurts and sexual maturation. Concurrently, the brain undergoes maturation processes that underlie higher cognitive functions. The combination of biological changes and environmental influences affect adolescent socioemotional and behaviour patterns. There is a need to raise the human potential of adolescents who will go on to become the next generation of our adult workforce, so that they lead productive, healthy, and fulfilling lives. Yet, in many developed countries, the rates of loss of subjective well-being in young people have at least doubled in the decade prior to COVID-19 and have continued to rise since 10. In the Singapore Youth Epidemiology and Resilience Study (2020-2022), 1 in 3 youths reported experiencing mental health symptoms 11. This requires the development of a cohesive response system designed to deal with the numerous factors influencing adolescent physical and mental health. Moreover, it is essential to investigate the developmental origins of metabolic diseases and neurodevelopmental disorders, which both form a major public health burden in Singapore, from as early as the adolescence phase. A transdisciplinary approach is essential to help adolescents directly recognise their diverse concerns, challenges and experiences and better understand how to manage their health and well-being. This requires going beyond traditional psychological models of mental health to examine the influences of brain and body interaction, socio-affective, behavioural and psychological development that shape adolescents' well-being. At present, there is no comprehensive multi-disciplinary (brain-body-environment) study in the general population which examine adolescent health and well-being holistically in Asia. Findings from primarily Western countries cannot be easily extrapolated to the Singaporean/Asian setting. A new holistic programme will be essential to advance the health of Asian adolescents.

• Study Type: Observational
• Enrollment (Estimated): 1200

Contacts and Locations

• Study Contact: Name: Janet Lim; Phone Number: 88546302; Email: janet_lim@sics.a-star.edu.sg

Study Locations

• Singapore
  • Singapore, Singapore
    • Enrolling by invitation
    • Singapore Institute of Clinical Sciences
  • Singapore
    • Singapore, Singapore, Singapore, 117609
      • Recruiting
      • A*STAR Institute for Human Development and Potential (IHDP)
      • Contact: Janet Lim, BS; Phone Number: 6407 0364; Email: janet_lim@sics.a-star.edu.sg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Secondary students aged between 13 -15 years old, studying in MOE registered schools in Singapore. Part of the DREAMS study cohort.

Description

Inclusion Criteria:

1. Aged 13 to 15 years of age
2. Currently studying in MOE registered school
3. Part of the DREAMS study

Exclusion Criteria:

1. Not in MOE registered school
2. Not part of the DREAMS study

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Participant of the study; Adolescents at 13- 15 years of age, currently studying in MOE-registered secondary school in Singapore and part of the DREAMS cohort.	Other: No intervention; No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Child health and environmental factors	Child's physical health and environment status	2 years
Social Science factors	Child's mental health status	2 years

Collaborators and Investigators

• Sponsor: Institute for Human Development and Potential (IHDP), Singapore
• Collaborators: Nanyang Technological University; National Institute of Education; Institute of High Performance Computing (IHPC), A*STAR Research Institutes

Study record dates

Study Major Dates

• Study Start (Actual): May 21, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: September 30, 2024
• First Submitted That Met QC Criteria: September 30, 2024
• First Posted (Actual): October 2, 2024

Study Record Updates

• Last Update Posted (Actual): December 30, 2025
• Last Update Submitted That Met QC Criteria: December 22, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 2024-1200

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: PDPA of study participants who are minors

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No