Isokinetic Training Combined with Blood Flow Restriction on Muscle Strength and Endurance

The Effect of 8-week Isokinetic Training Combined with Blood Flow Restriction on Muscle Strength and Endurance in Runners

Evidence regarding the effectiveness of blood flow restriction during isokinetic exercises is insufficient. When the literature is reviewed, it is seen that there are very few studies investigating the effect of isokinetic training program with blood flow restriction on muscle strength and endurance in healthy athletes. In line with this information, the aim of this study was to investigate the effect of an 8-week isokinetic training program combined with blood flow restriction on knee flexor and extensor maximal muscle strength and endurance in runners.

Study Overview

• Status: Completed
• Conditions: Blood Flow Restriction
• Intervention / Treatment: Device: the isokinetic training group with blood flow restriction; Device: the isokinetic training group without blood flow restriction

Detailed Description

The purpose of this study is to investigate the effect of lower extremity isokinetic training combined with blood flow restriction (BFR) on knee flexor and extensor muscle strength and endurance in runners. A total of 42 runners were randomly assigned to either the isokinetic training group with blood flow restriction (BFR Group; n= 21) or the isokinetic training group without blood flow restriction (Control Group; n= 21). For the BFR, the occlusion pressure was set to 80% of arterial occlusion pressure as determined. The isokinetic training protocol for the knee flexor and extensor muscles consisted of 3 sets of 10 repetitions in 60°/sec and 3 sets of 30 repetitions in 180°/sec for 8 weeks, 2 times per week for 16 sessions. The muscle strength and endurance were evaluated before and after the training program using an isokinetic dynamometer.

• Study Type: Interventional
• Enrollment (Actual): 42
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey
    • Bihter Akınoğlu
  • Ankara, Turkey, 06018
    • University of Health Sciences, Gulhane Faculty of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria: the absence of heart disease, arterial hypertension, diabetes mellitus or any musculoskeletal condition of the lower extremities that precluded participation in the recommended training protocols and testing, no use of any dietary supplements during the study and for at least 2 months prior to the study and running more than 20 kilometers per week.

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Exclusion Criteria: Age <20 or >40, history of cardiac disease, history of heart failure, history of coronary artery disease, history of peripheral artery disease, presence/history of varicose veins, history of hypertension, history of diabetes mellitus, history of pulmonary disease, history of pulmonary embolism, history of hematological disease, history of previous deep vein thrombosis, pregnancy, use of oral contraceptives, use of anticoagulants, history of previous surgery in the lower extremity, body mass index >25, history of cancer, presence of lymphedema, history of lymphadenectomy, history of trauma in the lower extremity within the last 6 months or 1 year.

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Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: The isokinetic training group with blood flow restriction (BFR Group); For the BFR, the occlusion pressure was set to 80% of arterial occlusion pressure as determined. The isokinetic training protocol for the knee flexor and extensor muscles consisted of 3 sets of 10 repetitions in 60°/sec and 3 sets of 30 repetitions in 180°/sec for 8 weeks, 2 times per week for 16 sessions.	Device: the isokinetic training group with blood flow restriction; The isokinetic training protocol for the knee flexor and extensor muscles consisted of 3 sets of 10 repetitions in 60°/sec and 3 sets of 30 repetitions in 180°/sec for 8 weeks, 2 times per week for 16 sessions.
Other: The isokinetic training group without blood flow restriction (Control Group); The isokinetic training group without blood flow restriction. The isokinetic training protocol for the knee flexor and extensor muscles consisted of 3 sets of 10 repetitions in 60°/sec and 3 sets of 30 repetitions in 180°/sec for 8 weeks, 2 times per week for 16 sessions	Device: the isokinetic training group without blood flow restriction; The isokinetic training protocol for the knee flexor and extensor muscles consisted of 3 sets of 10 repetitions in 60°/sec and 3 sets of 30 repetitions in 180°/sec for 8 weeks, 2 times per week for 16 sessions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluation of lower extremity muscle strength and muscular endurance using isokinetic dynamometry in runners who met the inclusion criteria for the study.	Isokinetic knee flexor and extensor muscles strength and endurance were evaluated with the isokinetic dynamometer. All the athletes underwent twice a week for 8 weeks of isokinetic training protocol. Both groups performed the same isokinetic training protocol. Blood flow restriction was applied to the BFR group while the athletes doing isokinetic training protocol, but not to the control group. Isokinetic knee flexor and extensor muscles strength and endurance were re- evaluated at the end of the intervention (48 hours after the last training session).	Baseline and 8 weeks

Collaborators and Investigators

• Sponsor: Bihter Aslanyurek
• Investigators: Study Director: Yasemin F. Çetinkaya, MD, Gulhane Training and Research Hospital

Study record dates

Study Major Dates

• Study Start (Actual): July 15, 2022
• Primary Completion (Actual): June 15, 2024
• Study Completion (Actual): June 15, 2024

Study Registration Dates

• First Submitted: November 4, 2024
• First Submitted That Met QC Criteria: November 5, 2024
• First Posted (Estimated): November 7, 2024

Study Record Updates

• Last Update Posted (Estimated): November 7, 2024
• Last Update Submitted That Met QC Criteria: November 5, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Keywords: blood flow restriction (BFR); isokinetic training
• Other Study ID Numbers: Gulhane; 321S398 (Other Grant/Funding Number: Scientific and Technological Research Council of Türkiye)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: Supporting information (data) will be shared once it is available for publication.
• IPD Sharing Time Frame: Supporting information will be shared once it is available for publication.
• IPD Sharing Access Criteria: Supporting information will be uploaded to the journal in which it is submitted for publication.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No