Does Surgical Treatment of Cartilage Defects Prevent Osteoarthritis in Later Life? (REACT)

January 6, 2026 updated by: Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

Cell Therapy for Osteoarthritis

Observational study to assess the effectiveness of cell therapy for the treatment of osteoarthritis

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

650

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
      • Oswestry, United Kingdom, Sy10 7AG
        • Recruiting
        • The Robert Jones and Agnes Hunt Orthopaedic Hospital
        • Contact:
        • Contact:
          • Wright
      • Oswestry, United Kingdom
        • Recruiting
        • Robert Jones and Agnes Hunt Orthopaedic hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients based in the United Kingdom treated at RJAH orthopaedic hospital

Description

Inclusion Criteria:

  • ACI patients or patients receiving an alternative treatment

Exclusion Criteria:

  • Anyone who does not meet the inclusion criteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
ACI patiients
Patient must have had ACI surgery at least 10 months prior
Non ACI Patients
Control group of patients who did not have ACI

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cell Therapy Questionnaire
Time Frame: At least fifteen months post operation
Cell Therapy Questionnaire CTQ
At least fifteen months post operation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

Collaborators

Keele University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 13, 2010

Primary Completion (Estimated)

January 12, 2030

Study Completion (Estimated)

January 12, 2030

Study Registration Dates

First Submitted

December 21, 2025

First Submitted That Met QC Criteria

December 21, 2025

First Posted (Estimated)

January 6, 2026

Study Record Updates

Last Update Posted (Actual)

January 8, 2026

Last Update Submitted That Met QC Criteria

January 6, 2026

Last Verified

December 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RL1 418

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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