VCMX, PRF and SCTG Treatment in the Gingival Recessions

Comparison of Volume Stable Collagen Matrix, Platelet-Rich Fibrin and Connective Tissue Graft in the Treatment of Multiple Gingival Recessions: A Randomized, Parallel Group, Controlled Clinical Trial

Comparison of Volume-Stable Collagen Matrix, Platelet-Rich Fibrin, and Subepithelial Connective Tissue Graft in the Treatment of Multiple Adjacent Gingival Recessions: A Parallel-Group, Randomized, Controlled Clinical Trial

Study Overview

• Status: Completed
• Conditions: Gingival Recession, Localized
• Intervention / Treatment: Biological: Volume-Stable Collagen Matrix

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Phase 3

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Ankara, Turkey (Türkiye)
    • Ankara Yıldırım Beyazit University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion criteria were as follows:

1. ≥2 mm buccal recessions affecting ≥2 adjacent maxillary teeth;
2. systemically and periodontally healthy;
3. non-smokers;
4. Miller Class I-II (no interproximal attachment or CEJ loss);
5. probing depth (PD) <3 mm;
6. GT ≥1 mm;
7. KGW ≥2 mm;
8. identifiable CEJ;
9. full-mouth plaque index (PI) <20%(O'Leary et al., 1972) and gingival index (GI) score of 0(Löe, 1967) and
10. vital teeth to be treated.

Exclusion criteria included:

1. smokers;
2. caries/restorations/abrasions in the treated area, furcation involvement;
3. contraindications to surgery;
4. pregnancy or lactation;
5. medications compromising healing;
6. surgery in the same region within 2 years;
7. bleeding disorders;
8. requirement for antibiotic prophylaxis; and
9. collagen allergy.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Volume Stable Collagen Matrix+Coronally Advanced Flap; The pre-prepared Volume Stable Collagen Matrix will be moistened with saline solution (SF) and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.	Biological: Volume-Stable Collagen Matrix; Volume-Stable Collagen Matrix
Active Comparator: Platelet-Rich Fibrin+Coronally Advanced Flap; Autologous platelet-rich fibrin (PRF) will be prepared from the patient's venous blood according to a standardized protocol and placed beneath a coronally advanced flap at the recipient site during periodontal surgery to enhance soft tissue healing and regeneration.	Biological: Volume-Stable Collagen Matrix; Volume-Stable Collagen Matrix
Active Comparator: Subepithelial Connective Tissue Graft+Coronally Advanced Flap; A subepithelial connective tissue graft harvested from the patient's palate and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.	Biological: Volume-Stable Collagen Matrix; Volume-Stable Collagen Matrix

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of Complete Root Coverage	Percentage of CRC will be calculated as: (number of teeth achieving complete root coverage) ÷ (total treated teeth)] × 100	12 Months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of Mean Root Coverage	Percentage of root coverage will be calculated as: Percentage of root coverage: [(preoperative recession depth - postoperative recession depth) ÷ preoperative recession depth] × 100	12 months
Recession depth	RD will be measured from the cemento-enamel junction (CEJ) to the gingival margin and reported in millimeters (mm).	12 month
Probing depth	Probing depth will be measured from the gingival margin to the base of the sulcus and reported in millimeters (mm).	12 months
Clinical attachment level	Clinical attachment level will be measured from the cemento-enamel junction to the sulcus base and reported in millimeters (mm).	12 months
Keratinized gingiva width	KGW will be measured from the mucogingival junction to the gingival margin and reported in millimeters (mm).	12 months
Gingival Thickness	Gingival thickness (GT) will beevaluated at the mid-facial aspect, 2 mm apical to the gingival margin in the attached gingiva or alveolar mucosa, using a #15 endodontic spreader (Bahadır Diş, Istanbul, Turkey) with a rubber stopper under local anesthesia and reported in milimeters.	12 months
Postoperative Pain assessed using a Visual Analog Scale (VAS)	Postoperative pain will be assessed using a visual analog scale (VAS). Patients were asked to record the highest perceived pain each day from the day of surgery through the 10th postoperative day (total of 11 days).	From the day of surgery through postoperative day 10 (11 days)
Dentin Hypersensitivity Score assessed using Air Stimulus (HSS)	Dentin hypersensitivity will be assessed using a 1-second air stimulus applied to the buccal surface of the treated tooth. Patients rated the perceived hypersensitivity on a numerical rating scale ranging from 0 (no hypersensitivity) to 10 (unbearable hypersensitivity).	Baseline, 6 months, and 12 months
Pink Esthetic Score (PES) self-assessment	Esthetic outcomes will be evaluated using the Pink Esthetic Score (PES). Patients self-assessed gingival contour, gingival color, and overall esthetic appearance using a numerical rating scale ranging from 0 (unpleasant) to 10 (excellent).	Baseline, 6 months, and 12 months
Postoperative Analgesic Consumption	Postoperative analgesic consumption will be assessed by recording the total number of analgesic tablets taken by patients from the day of surgery through the 10th postoperative day.	From the day of surgery through postoperative day 10 (11 days)

Collaborators and Investigators

• Sponsor: Bulent Ecevit University

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2022
• Primary Completion (Actual): October 1, 2024
• Study Completion (Actual): October 1, 2024

Study Registration Dates

• First Submitted: November 23, 2025
• First Submitted That Met QC Criteria: January 7, 2026
• First Posted (Actual): January 15, 2026

Study Record Updates

• Last Update Posted (Actual): January 15, 2026
• Last Update Submitted That Met QC Criteria: January 7, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Gingival Diseases; Gingival Recession
• Other Study ID Numbers: 21.12.2022/12

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No