- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT07526610
Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit
April 6, 2026 updated by: Sara González-Martín, Universidad Rey Juan Carlos
The data for this retrospective study were collected from the records of patients admitted to the intensive care unit (ICU) for burns at Hospital La Paz from January 1, 2019 to May 31, 2023.
Study Overview
Status
Completed
Conditions
- Burn Degree Second
- Burn Degree Third
- Burn Any Degree Involving 20-29 Percent of Body Surface
- Burn Any Degree Involving 30-39 Percent of Body Surface
- Burn Any Degree Involving 40-49 Percent of Body Surface
- Burn Any Degree Involving 50-59 Percent of Body Surface
- Burn Any Degree Involving 60-65 Percent of Body Surface
Detailed Description
The complete medical records of 710 patients admitted to this burn ICU were reviewed.
Patients older than 18 years were included, regardless of burned body surface area (BBS (%)), who met the criteria for admission to the ICU for burns according to the American Burn Association [17].
Therefore, a total sample size of 465 participants was recruited.
A sample were recruited by a consecutive sampling method using a successive and non-aleatorized simple method.
Subjects were enlisted from the Intensive Care Unit (ICU) for burns at the La Paz Hospital (Madrid- Spain).
Study Type
Observational
Enrollment (Actual)
465
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Madrid
-
Alcorcón, Madrid, Spain, 28922
- Faculty of Health Sciences
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Patients admitted to this burn ICU
Description
Inclusion Criteria:
- Patients older than 18 years
- Regardless of burned body surface area (BBS (%))
- Met the criteria for admission to the ICU for burns according to the American Burn Association
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
|---|
|
Burn patients
hospitalized burn patients
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
In-hospital Mortality
Time Frame: 2 years
|
In-hospital Mortality
|
2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Queiroz LF, Anami EH, Zampar EF, Tanita MT, Cardoso LT, Grion CM. Epidemiology and outcome analysis of burn patients admitted to an Intensive Care Unit in a University Hospital. Burns. 2016 May;42(3):655-62. doi: 10.1016/j.burns.2015.08.002. Epub 2016 Jan 4.
- Osler T, Glance LG, Hosmer DW. Simplified estimates of the probability of death after burn injuries: extending and updating the baux score. J Trauma. 2010 Mar;68(3):690-7. doi: 10.1097/TA.0b013e3181c453b3.
- Brusselaers N, Monstrey S, Vogelaers D, Hoste E, Blot S. Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality. Crit Care. 2010;14(5):R188. doi: 10.1186/cc9300. Epub 2010 Oct 19.
- Smolle C, Cambiaso-Daniel J, Forbes AA, Wurzer P, Hundeshagen G, Branski LK, Huss F, Kamolz LP. Recent trends in burn epidemiology worldwide: A systematic review. Burns. 2017 Mar;43(2):249-257. doi: 10.1016/j.burns.2016.08.013. Epub 2016 Sep 3.
- Williams FN, Strassle PD, Knowlin L, Napravnik S, van Duin D, Charles A, Nizamani R, Jones SW, Cairns BA. Sex-Based Differences in Inpatient Burn Mortality. World J Surg. 2019 Dec;43(12):3035-3043. doi: 10.1007/s00268-019-05165-x.
- Bagheri M, Fuchs PC, Lefering R, Grigutsch D, Busche MN, Niederstatter I, The German Burn Registry, Schiefer JL. Effect of comorbidities on clinical outcome of patients with burn injury - An analysis of the German Burn Registry. Burns. 2021 Aug;47(5):1053-1058. doi: 10.1016/j.burns.2020.04.040. Epub 2020 May 13.
- Knowlin L, Reid T, Williams F, Cairns B, Charles A. Burn mortality in patients with preexisting cardiovascular disease. Burns. 2017 Aug;43(5):949-955. doi: 10.1016/j.burns.2017.01.026. Epub 2017 Feb 8.
- Abarca L, Guilabert P, Martin N, Usua G, Barret JP, Colomina MJ. Epidemiology and mortality in patients hospitalized for burns in Catalonia, Spain. Sci Rep. 2023 Sep 1;13(1):14364. doi: 10.1038/s41598-023-40198-2.
- Woods JF, Quinlan CS, Shelley OP. Predicting Mortality in Severe Burns-What Is the Score?: Evaluation and Comparison of 4 Mortality Prediction Scores in an Irish Population. Plast Reconstr Surg Glob Open. 2016 Feb 5;4(1):e606. doi: 10.1097/GOX.0000000000000584. eCollection 2016 Jan. No abstract available.
- Pantet O, Faouzi M, Brusselaers N, Vernay A, Berger MM. Comparison of mortality prediction models and validation of SAPS II in critically ill burns patients. Ann Burns Fire Disasters. 2016 Jun 30;29(2):123-129.
- Romanowski KS, Sen S. Wound healing in older adults with severe burns: Clinical treatment considerations and challenges. Burns Open. 2022 Apr;6(2):57-64. doi: 10.1016/j.burnso.2022.01.002. Epub 2022 Feb 1.
- Lundgren RS, Kramer CB, Rivara FP, Wang J, Heimbach DM, Gibran NS, Klein MB. Influence of comorbidities and age on outcome following burn injury in older adults. J Burn Care Res. 2009 Mar-Apr;30(2):307-14. doi: 10.1097/BCR.0b013e318198a416.
- Obed D, Salim M, Dastagir N, Knoedler S, Dastagir K, Panayi AC, Vogt PM. Comparative Analysis of Composite Mortality Prediction Scores in Intensive Care Burn Patients. Int J Environ Res Public Health. 2022 Sep 28;19(19):12321. doi: 10.3390/ijerph191912321.
- Greenhalgh DG, Hill DM, Burmeister DM, Gus EI, Cleland H, Padiglione A, Holden D, Huss F, Chew MS, Kubasiak JC, Burrell A, Manzanares W, Gomez MC, Yoshimura Y, Sjoberg F, Xie WG, Egipto P, Lavrentieva A, Jain A, Miranda-Altamirano A, Raby E, Aramendi I, Sen S, Chung KK, Alvarez RJQ, Han C, Matsushima A, Elmasry M, Liu Y, Donoso CS, Bolgiani A, Johnson LS, Vana LPM, de Romero RVD, Allorto N, Abesamis G, Luna VN, Gragnani A, Gonzalez CB, Basilico H, Wood F, Jeng J, Li A, Singer M, Luo G, Palmieri T, Kahn S, Joe V, Cartotto R. Surviving Sepsis After Burn Campaign. Burns. 2023 Nov;49(7):1487-1524. doi: 10.1016/j.burns.2023.05.003. Epub 2023 May 6.
- Hirche C, Kreken Almeland S, Dheansa B, Fuchs P, Governa M, Hoeksema H, Korzeniowski T, Lumenta DB, Marinescu S, Martinez-Mendez JR, Plock JA, Sander F, Ziegler B, Kneser U. Eschar removal by bromelain based enzymatic debridement (Nexobrid(R)) in burns: European consensus guidelines update. Burns. 2020 Jun;46(4):782-796. doi: 10.1016/j.burns.2020.03.002. Epub 2020 Mar 30.
- Shoham Y, Gasteratos K, Singer AJ, Krieger Y, Silberstein E, Goverman J. Bromelain-based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long-term outcomes. Int Wound J. 2023 Dec;20(10):4364-4383. doi: 10.1111/iwj.14308. Epub 2023 Jul 16.
- Bagheri M, Fuchs PC, Lefering R, Daniels M, Schulz A, The German Burn Registry, Schiefer JL. The BUrn Mortality Prediction (BUMP) Score - An improved mortality prediction score based on data of the German burn registry. Burns. 2023 Feb;49(1):110-119. doi: 10.1016/j.burns.2022.02.007. Epub 2022 Feb 9.
- Bartels P, Thamm OC, Elrod J, Fuchs P, Reinshagen K, German Burn Registry, Koenigs I. The ABSI is dead, long live the ABSI - reliable prediction of survival in burns with a modified Abbreviated Burn Severity Index. Burns. 2020 Sep;46(6):1272-1279. doi: 10.1016/j.burns.2020.05.003. Epub 2020 May 19.
- Belgian Outcome in Burn Injury Study Group. Development and validation of a model for prediction of mortality in patients with acute burn injury. Br J Surg. 2009 Jan;96(1):111-7. doi: 10.1002/bjs.6329.
- Galeiras R, Lorente JA, Pertega S, Vallejo A, Tomicic V, de la Cal MA, Pita S, Cerda E, Esteban A. A model for predicting mortality among critically ill burn victims. Burns. 2009 Mar;35(2):201-9. doi: 10.1016/j.burns.2008.07.019. Epub 2008 Nov 18.
- Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG. Objective estimates of the probability of death from burn injuries. N Engl J Med. 1998 Feb 5;338(6):362-6. doi: 10.1056/NEJM199802053380604.
- Melo FL, Gragnani A, de Oliveira AF, Ferreira LM. Predicting mortality for critically ill burns patients, using the Abbreviated Burn Severity Index and Simplified Acute Physiology Score 3. Injury. 2022 Feb;53(2):453-456. doi: 10.1016/j.injury.2021.11.027. Epub 2021 Nov 15.
- Obed D, Schroeter A, Gruber L, Bucher F, Salim M, Bingoel AS, Krezdorn N, Dastagir K, Vogt PM. Epidemiology and outcome analysis of 1359 intensive care burn patients: A 14-year retrospective study in a major burn center. Burns. 2023 Aug;49(5):1209-1217. doi: 10.1016/j.burns.2022.08.022. Epub 2022 Sep 8.
- Thombs BD. Do more predictors improve mortality risk estimates among burn patients? Comment on McGwin et al. Burns. 2009 Mar;35(2):303-4; author reply 305. doi: 10.1016/j.burns.2008.04.013. Epub 2008 Oct 19. No abstract available.
- Forster NA, Zingg M, Haile SR, Kunzi W, Giovanoli P, Guggenheim M. 30 years later--does the ABSI need revision? Burns. 2011 Sep;37(6):958-63. doi: 10.1016/j.burns.2011.03.009. Epub 2011 Apr 13.
- Brusselaers N, Monstrey SJ, Vandijck DM, Blot SI. Prediction of morbidity and mortality on admission to a burn unit. Plast Reconstr Surg. 2007 Jul;120(1):360-361. doi: 10.1097/01.prs.0000264577.72790.6f. No abstract available.
- Meshulam-Derazon S, Nachumovsky S, Ad-El D, Sulkes J, Hauben DJ. Prediction of morbidity and mortality on admission to a burn unit. Plast Reconstr Surg. 2006 Jul;118(1):116-20. doi: 10.1097/01.prs.0000221111.89812.ad.
- Grant EJ. Burn Injuries: Prevention, Advocacy, and Legislation. Clin Plast Surg. 2017 Jul;44(3):451-466. doi: 10.1016/j.cps.2017.02.005.
- Peck MD. Epidemiology of burns throughout the world. Part I: Distribution and risk factors. Burns. 2011 Nov;37(7):1087-100. doi: 10.1016/j.burns.2011.06.005. Epub 2011 Jul 29.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2019
Primary Completion (Actual)
May 31, 2023
Study Completion (Actual)
January 1, 2026
Study Registration Dates
First Submitted
April 6, 2026
First Submitted That Met QC Criteria
April 6, 2026
First Posted (Actual)
April 13, 2026
Study Record Updates
Last Update Posted (Actual)
April 13, 2026
Last Update Submitted That Met QC Criteria
April 6, 2026
Last Verified
April 1, 2026
More Information
Terms related to this study
Other Study ID Numbers
- 2023.59
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
In order to comply with current data protection laws, the study data will not be shared
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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