Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge (CGF)

April 10, 2026 updated by: Tasneem farrag abdelkader ayoup, Cairo University

Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge (Case Series).

This study aims to evaluate the tissue biotype and bone density around dental implants in patients with narrow alveolar ridge. Ridge splitting with simultaneous implant placement covered with concentrated growth factor (CGF) membranes will be performed. Clinical and radiographic evaluation will be done using periodontal probe and CBCT. Pain will also be assessed using visual analogue scale (VAS) during follow-up period.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

This study is a case series conducted at the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. It aims to evaluate the tissue biotype and bone density around dental implants in adult patients with narrow alveolar ridge.

Alveolar ridge resorption and soft tissue shrinkage after tooth extraction represent a major problem affecting both aesthetics and function. Therefore, preserving alveolar bone and improving soft tissue conditions are essential for successful implant placement. The use of concentrated growth factor (CGF) membranes combined with ridge splitting and simultaneous implant placement may enhance healing, reduce postoperative pain, and improve tissue biotype and bone density.

All patients will undergo clinical and radiographic assessment before the procedure. Preoperative CBCT will be used for surgical planning. Tissue thickness will be measured using a periodontal probe. During surgery, ridge splitting will be performed followed by implant placement, and CGF membranes will be applied over the grafted area. Autologous bone chips will be used for augmentation.

Postoperative evaluation will include assessment of tissue biotype, bone density using CBCT, and pain using visual analogue scale (VAS). Follow-up will be carried out immediately after surgery and up to 4 months postoperatively.

Study Type

Interventional

Enrollment (Estimated)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

-

Patients with narrow alveolar ridge indicated for implant placement Age between 20 and 50 years Good general health Patients with adequate oral hygiene

Exclusion Criteria:

  • Patients with systemic diseases affecting bone healing Smokers Pregnant or lactating females Patients with poor oral hygiene Patients with history of radiation therapy in the head and neck region

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Ridge Splitting with Simultaneous Implant Placement and CGF
Patients with narrow alveolar ridge will undergo ridge splitting with simultaneous implant placement. Concentrated growth factor (CGF) membranes will be prepared from the patient's blood and placed over the grafted area. Autologous bone chips will be used for augmentation. Clinical and radiographic evaluation will be performed to assess tissue biotype, bone density, and pain during follow-up period.
Procedure: Ridge splitting
Patients with narrow alveolar ridge will undergo ridge splitting procedure using chisel to allow implant placement.
Procedure: Dental implant placement

Intervention Description:

Dental implants will be inserted simultaneously after ridge splitting in the prepared alveolar ridge.

Biological: Concentrated Growth Factor (CGF)
CGF membranes will be prepared from patient venous blood and placed over the grafted area to enhance healing and tissue regeneration.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain (VAS score)
Time Frame: 1st day and 3rd day postoperative
Pain will be assessed using Visual Analogue Scale (VAS) ranging from 0 to 10.
1st day and 3rd day postoperative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Tissue biotype thickness
Time Frame: Immediately postoperative and after 4 months
Tissue biotype will be assessed using a periodontal probe and measured in millimeters.
Immediately postoperative and after 4 months

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Bone density
Time Frame: Immediately postoperative and after 4 months
Bone density will be evaluated using CBCT and measured in Hounsfield units (HU).
Immediately postoperative and after 4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Investigators

  • Study Director: Abdelmoez Mohamed El-Sharkawy, Associate Professor, Cairo University
  • Study Chair: Hesham Said Said, Professor, Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

December 30, 2026

Study Registration Dates

First Submitted

April 10, 2026

First Submitted That Met QC Criteria

April 10, 2026

First Posted (Actual)

April 16, 2026

Study Record Updates

Last Update Posted (Actual)

April 16, 2026

Last Update Submitted That Met QC Criteria

April 10, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Omfs 3-3-18.

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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