TREMOR IN CHARCOT-MARIE-TOOTH (CMT-TREM)

Investigation of Tremor in Patients With Charcot-Marie-Tooth Neuropathy

Tremor is a symptom that has already been described in many case reports and case series concerning patients with Charcot-Marie-Tooth (CMT) disease. However, the pathophysiology of tremor in this condition remains largely unclear. It has also not been sufficiently investigated to what extent tremor in CMT patients constitutes a relevant impairment of quality of life.

This project focuses on a more detailed characterization of tremor in CMT patients using surface electromyography and accelerometer analysis, as well as the collection of individual clinical data, particularly regarding the symptom of tremor, in order to facilitate the characterization and etiological classification of the tremor. In addition, a questionnaire-based assessment will be conducted to capture the impact of tremor on activities of daily living and the associated burden in this specific patient cohort.

The entire data collection process will be supported by a clinical examination, which will be video-recorded by experienced neurologists to ensure more reliable analysis. This serves both the characterization of tremor and the illustration of its functional limitations. Where available, the data will be correlated with genetic variants to allow conclusions about possible genetic predispositions or disease progression. As a control group, CMT patients who have not yet reported a tremor will be included.

Study Overview

• Status: Recruiting
• Conditions: Charcot Marie Tooth Disease; CMT (Charcot Marie Tooth Disease); CMT; Charcot Marie Tooth Disease (CMT)

• Study Type: Observational
• Enrollment (Estimated): 75

Contacts and Locations

• Study Contact: Name: Michael W Sereda, Prof. MD; Phone Number: +49 551 3964162; Email: sereda@mpinat.mpg.de

Study Locations

• Germany
  • Lower Saxony
    • Göttingen, Lower Saxony, Germany, 37075
      • Recruiting
      • University Medical Centre
      • Contact: Sandrin Plewe; Phone Number: +49 551 3964162; Email: sandrin.plewe@med.uni-goettingen.de

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

CMT-patients and healthy controls

Description

Inclusion Criteria:

• Clinical CMT Diagnosis / Anamnestically Healthy Control Group
• Genetic confirmation of CMT in adult patients
• Ability to achieve the outcome measure at baseline
• Age between 18 and 65 years
• Capacity of all study participants to consent and signed informed consent, including patient or participant information and consent form

Exclusion Criteria:

• Pregnancy or breastfeeding period
• Other relevant neurological or psychiatric disorders, acute or in the past history
• Presence of a serious previous internal disease

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Controls
CMT patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Activities of Daily Living -Questionaire(ADL)	baseline
Assessment of Handicap - Questionaire	baseline
Fahn Tolosa Marin Rating Scale	baseline
Electrophysiological characterization of tremor using surface EMG and accelerometer analysis	baseline

Secondary Outcome Measures

Outcome Measure	Time Frame
MDS-UPDRS Part III without Tremor	baseline
SARA Score	baseline

Collaborators and Investigators

• Sponsor: University Medical Center Goettingen

Study record dates

Study Major Dates

• Study Start (Actual): July 30, 2024
• Primary Completion (Estimated): July 5, 2026
• Study Completion (Estimated): October 30, 2026

Study Registration Dates

• First Submitted: April 9, 2026
• First Submitted That Met QC Criteria: April 29, 2026
• First Posted (Actual): May 6, 2026

Study Record Updates

• Last Update Posted (Actual): May 6, 2026
• Last Update Submitted That Met QC Criteria: April 29, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Tremor in CMT
• Additional Relevant MeSH Terms: Nervous System Diseases; Neuromuscular Diseases; Genetic Diseases, Inborn; Peripheral Nervous System Diseases; Neurodegenerative Diseases; Congenital Abnormalities; Heredodegenerative Disorders, Nervous System; Nervous System Malformations; Polyneuropathies; Hereditary Sensory and Motor Neuropathy; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Charcot-Marie-Tooth Disease
• Other Study ID Numbers: 17/05/2024_C3

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No