Comparative Evaluation of Alb PRF Versus Connective Tissue Graft in Reconstruction of Deficient Interdental Papilla

May 13, 2026 updated by: ahmed mostafa ahmed abo el soud

Evaluation of Albumin Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft in Interdental Papilla Reconstruction: a Randomized Controlled Clinical Trial

This study will evaluate the efficacy of Alb PRF membrane in comparison to a subepithelial connective tissue graft in the reconstruction of interdental papillae.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

the reconstruction will be done using the Hans Taki surgical technique, while Alb PRF will be used as a membrane.

Study Type

Interventional

Enrollment (Estimated)

28

Phase

  • Phase 3

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • inter dental papilla deficincy

Exclusion Criteria:

  • smokers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: connective tissue graft
Biological: connective tissue graft
subepithelial connective tissue graft
Experimental: Albumin plasma rich fibrin membrane
Biological: Albumin (5% serum-protein solution containing immunoglobulins)
a variation of PRF done by heating up to 75 degree then mixed with the remaining prf to get membrane

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
papillary height measured from apical part of contact point to tip of papilla (CP-TP)
Time Frame: from enrollment, 3 months, 6months, 9months, 12months
from enrollment, 3 months, 6months, 9months, 12months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

ahmed mostafa ahmed abo el soud

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 20, 2026

Primary Completion (Estimated)

September 20, 2028

Study Completion (Estimated)

December 20, 2028

Study Registration Dates

First Submitted

May 13, 2026

First Submitted That Met QC Criteria

May 13, 2026

First Posted (Actual)

May 19, 2026

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 13, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Alb-PRF vs connective tissue

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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