Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink

To assess cherry collagen drink on skin condition improvement

Study Overview

• Status: Completed
• Conditions: Skin Condition
• Intervention / Treatment: Dietary supplement: Placebo drink; Dietary supplement: Cherry collagen drink

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Tainan City, Taiwan, 71710
    • Chia Nan University of Pharmacy & Science

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy adults aged above 20 years old

Exclusion Criteria:

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, liver, kidney.
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
• Constant drug use
• Students who are currently taking courses taught by the principal investigator of this trial.
• Body weight < 50 kg.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo drink	Dietary supplement: Placebo drink; consume 1 sachet per day
Experimental: Cherry collagen drink	Dietary supplement: Cherry collagen drink; consume 1 sachet per day; Other Names: YOUNIQUE DAILY YOU liquid collagen shot

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin wrinkles	VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units	Change from Baseline skin wrinkles at 8 weeks
The change of skin texture	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units	Change from Baseline skin texture at 8 weeks
The change of skin collagen density	DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units	Change from Baseline skin collagen density at 8 weeks
The change of skin elasticity	Soft Plus was utilized to measure skin elasticity. Units: arbitrary units	Change from Baseline skin elasticity at 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin L* value	Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100	Change from Baseline L* value at 8 weeks
The change of skin moisture	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120	Change from Baseline skin moisture at 8 weeks
The change of skin UV spots	VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units	Change from Baseline skin UV spots at 8 weeks
The change of skin melanin index	Soft Plus was utilized to measure skin melanin index. Units: arbitrary units	Change from Baseline skin melanin index at 8 weeks
The change of blood total antioxidant capacity (TAC)	Venous blood was sampled to measure concentrations of TAC	Change from Baseline TAC at 8 weeks
The change of skin spots	VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units	Change from Baseline skin spots at 8 weeks
The change of skin brown spots	VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units	Change from Baseline skin brown spots at 8 weeks
The change of SOD-RBC of blood	Venous blood was sampled to measure SOD-RBC	Change from Baseline SOD-RBC at 8 weeks
The change of t-GSH of blood	Venous blood was sampled to measure t-GSH	Change from Baseline t-GSH at 8 weeks
The change of GST-RBC of blood	Venous blood was sampled to measure GST-RBC	Change from Baseline GST-RBC at 8 weeks
The change of desmosine of blood	Venous blood was sampled to measure concentrations of desmosine	Change from Baseline desmosine at 8 weeks
The change of TNF-alpha of blood	Venous blood was sampled to measure concentrations of TNF-alpha	Change from Baseline TNF-alpha at 8 weeks
The change of transepidermal water loss (TEWL)	Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²	Change from Baseline TEWL at 8 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of self-assessment skin condition	A self-assessment questionnaire was collected to evaluate skin condition	Change from Baseline skin condition at 8 weeks
The change of liver function biomarkers (AST, ALT) of blood	Venous blood was sampled to measure liver function biomarkers	Change from Baseline liver function biomarkers at 8 weeks
The change of renal function biomarkers (creatinine, BUN) of blood	Venous blood was sampled to measure renal function biomarkers	Change from Baseline renal function biomarkers at 8 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.
• Investigators: Principal Investigator: Chia-Hua Liang, Chia Nan University of Pharmacy & Science

Study record dates

Study Major Dates

• Study Start (Actual): April 1, 2022
• Primary Completion (Actual): July 20, 2022
• Study Completion (Actual): September 3, 2022

Study Registration Dates

• First Submitted: May 12, 2022
• First Submitted That Met QC Criteria: May 12, 2022
• First Posted (Actual): May 17, 2022

Study Record Updates

• Last Update Posted (Actual): September 29, 2022
• Last Update Submitted That Met QC Criteria: September 28, 2022
• Last Verified: September 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases
• Other Study ID Numbers: 22-010-B

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No