The Effect of Ultrasound-Guided Erector Spinae Plane Block on Postoperative Analgesia in Percutaneous Nephrolithotomy

The Effect of Ultrasound-Guided Erector Spinae Plane Block on Postoperative Analgesia in Percutaneous Nephrolithotomy: a Randomised Single-blind Trial

This study is planned as a single-center randomized single blinded study and includes patients undergoing percutaneous nephrolitotomy.The aim of the study is to evaluate the effect of ultrasound guided erector spinal plane block on postoperative analgesia in percutaneous nephrolitotomy. Primary outcome is the total 24 hour morphine consumption.

Study Overview

• Status: Completed
• Conditions: Regional Anaesthesia; Acute Postoperative Pain in Urological Surgery
• Intervention / Treatment: Procedure: Erector Spinae Plane Block; Procedure: Intravenous analgesia

Detailed Description

Adult patients aged 18-65 years with American Society of Anesthesiologists (ASA) physical status I-II scheduled for elective PCNL were allocated to receive either a unilateral ultrasound-guided ESPB at the T9 level with 20 mL of 0.25% bupivacaine followed by postoperative IV morphine PCA (Group ESPB ) or postoperative IV morphine PCA alone (Group C). 24 hour morphine consumption, numeric Rating Scale (NRS) pain scores, rescue analgesic requirements, sedation scores, opioid-related adverse effects, hospital stay, chronic pain, patient and surgeon satisfaction are recorded.

• Study Type: Interventional
• Enrollment (Actual): 56
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Fatih
    • Istanbul, Fatih, Turkey (Türkiye), 34093
      • Istanbul University, Istanbul Faculty of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Elective percutaneous nephrolitotomy
• American Society of Anesthesiologists (ASA) physical status I-II

Exclusion Criteria:

• Refusal to participate
• Coagulopathy,
• Infection at the block site
• Allergy to local anaesthetics
• Previous surgery in the block area
• Severe systemic disease.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Group erector spinae plane block (Group ESPB); Patients received erector spinae plane block for postoperative analgesia	Procedure: Erector Spinae Plane Block; Erector spinae plane block is applied in longitudinal plane at T9 level.
Active Comparator: Group Control (Group C); Patients received only intravenous analgesia	Procedure: Intravenous analgesia; Inravenous morphine is administered via patient controlled analgesia device.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Total 24-hour morphine consumption	Total 24-hour intravenous morphine consumption via patient controlled analgesia device	24 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Length of hospital stay	Length of hospital stay	Up to 1 week
Pain assessment	Pain assessment is evaluated using numeric rating scale (NRS 0-10; 0: no pain, 10: the worst pain imaginable)	24 hours
Additional analgesic requirement	If the Numeric Rating Scale (NRS) score exceeded 4, rescue analgesia consisted of additional morphine 0.02 mg/kg, plus intravenous paracetamol 1 g.	24 hours
Postoperative nausea and vomiting	Number of patients experienced postoperative nausea and vomiting .	24 hours
Patient satisfaction	Patient satisfaction is questioned using Likert scale:1-3 (1: dissatisfied, 2: neutral, 3: satisfied)	Up to 24 hours
Surgeon satisfaction	Surgeon satisfaction is questioned using Likert scale:1-3 (1: dissatisfied, 2: neutral, 3: satisfied)	Up to 24 hours
First rescue analgesic time	The first time patient required rescue analgesic	24 hours
Chronic pain	Chronic pain is evaluated using NRS scores and DN4 questionnaire	3 months
Pruritus	The number of patients experienced pruritus	24 hours

Collaborators and Investigators

• Sponsor: Istanbul University
• Investigators: Principal Investigator: Momunat Dadashova, MD, Liv Hospital Vadi Istanbul

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2019
• Primary Completion (Actual): April 30, 2021
• Study Completion (Actual): April 30, 2021

Study Registration Dates

• First Submitted: June 23, 2026
• First Submitted That Met QC Criteria: June 23, 2026
• First Posted (Actual): June 29, 2026

Study Record Updates

• Last Update Posted (Actual): June 29, 2026
• Last Update Submitted That Met QC Criteria: June 23, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Keywords: morphine; regional anaesthesia; postoperative analgesia; percutaneous nephrolithotomy; Erector spinae plane block
• Other Study ID Numbers: 2019/177

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No