Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block for Open Abendectomy Surgery

March 15, 2026 updated by: Ahmed Hasanin, Cairo University

Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial

this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

regional technique according to randomization will be given after induction of general anesthesia Fentanyl boluses of 1 mcg/kg will be given in case of inadequate analgesia. Inadequate analgesia identified by 20% increase in the heart rate and/or systolic blood pressure from baseline measurement.

postoperative analgesia: regular paracetamol 1 g/6 hours (intravenously at first then orally once the oral feeding is resumed) and 75 mg diclofenac (intramuscularly at first then orally once the oral feeding is resumed).

If Numeric rating scale (NRS) is > 3 intravenous titration of 2 mg morphine is given slowly to be repeated after 30 minutes if pain persisted

Study Type

Interventional

Enrollment (Estimated)

68

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypt
        • Recruiting
        • Cairo University
        • Contact:
          • ahmed Shash, Professor
          • Phone Number: +201001033999

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • adult patients, undergoing open appendectomy.

Exclusion Criteria:

  • American society of anesthesiologist-physical status >III,
  • allergy to any of the study drugs,
  • coagulopathy
  • local infection,
  • history of chronic pain or regular opioid use;
  • inability to comprehend the Numeric Rating Scale (NRS),
  • pregnant or lactating women.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: TAP group
Other: Transversus abdominis plane (TAP) block
Patient will received TAP block using the lateral approach while in supine position. A 20 mL of 0.25% bupivacaine will be injected after negative aspiration.
Active Comparator: ESP group
Other: Erector Spinae Plane Block
Patients will receive the ESP block at the level of the 10th thoracic (T10) transverse process using a linear 6-13 MHz ultrasound transducer. A 20 mL of 0.25% bupivacaine will be injected below the muscle

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total morphine consumption
Time Frame: from extubation until 24 hours postoperative
mg
from extubation until 24 hours postoperative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
numeric rating scale
Time Frame: AT 0.5, 2, 6, 12, and 24 hours postoperative.
a scale of 0-10, where 0 means "no pain" and 10 means "worst imaginable pain"
AT 0.5, 2, 6, 12, and 24 hours postoperative.
quality of recovery
Time Frame: 24 hours after suregry

assessed using Quality of recovery-15 (QOR-15); Consists of 15 items evaluating five dimensions of health: physical comfort, physical independence, psychological support, emotional state, and pain.

Scoring Range: Each item is rated on an 11-point numerical scale (0 to 10). The total score ranges from 0 (extremely poor recovery) to 150 (excellent recovery).
24 hours after suregry

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 25, 2026

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

May 1, 2026

Study Registration Dates

First Submitted

January 10, 2026

First Submitted That Met QC Criteria

January 10, 2026

First Posted (Actual)

January 20, 2026

Study Record Updates

Last Update Posted (Actual)

March 17, 2026

Last Update Submitted That Met QC Criteria

March 15, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MD-320-2024

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

data regarding this research will be available upon reasonable request from the PI

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Regional Anaesthesia

Clinical Trials on Erector Spinae Plane Block

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in South Korea

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe