Comparison of Alignment Speed, Patient Discomfort and Root Resorption Between Two Different Sequences of Archwires

August 11, 2026 updated by: Shoaib Rahim, Foundation University Islamabad
In this Clinical trial we aim to compare alignment speed, patient discomfort and root resorption between two different sequences of NiTi archwires

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This study will establish and evaluate a set of alignment wires that is efficient in terms of reduced number of patient's visits, yet periodontally safe and acceptable in terms of patient discomfort.

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Punjab Province
      • Islamabad, Punjab Province, Pakistan, 04403
        • Foundation University Islamabad
      • Islamabad, Punjab Province, Pakistan, 43000
        • FUI
      • Islamabad, Punjab Province, Pakistan, 46000
        • FUI

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Age range 12-35 years.

  • Both male and female patients.
  • Medically-fit patients with no medical condition associated with root resorption risk.
  • No previous history of orthodontic treatment.
  • Patients requiring complete upper and lower orthodontic treatment with fixed appliance.
  • Angle class I, II, and III malocclusion with crowding in both maxillary and mandibular anterior dentition.
  • Healthy permanent dentition with adequate oral hygiene and no periodontal diseases; before the start of orthodontic treatment.

Exclusion Criteria:

Cleft lip & palate patients

  • Syndromic patients
  • Patients with bone pathologies
  • Habits such as smoking
  • Patients with parafunctional habits or history of pre-existing root resorption
  • Patients taking drugs which inhibit or accelerate tooth movement
  • Tooth or teeth with periapical infection.
  • Patients with pain from any other medical or dental condition that may have affected their reported discomfort scores were excluded
  • Endodontically treated mandibular or maxillary anterior teeth
  • Presence of blocked-out tooth that did not allow for placement of the bracket or full AW engagement at the initial bonding.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Treatment two archwires
Patients undergoing archwire sequence as follows 0.014 inch NiTi 0.019x0.025 inch NiTi
Device: Archwire
NiTi Archwires will be used for tooth alignment
Experimental: Treatment with five archwires
Patients undergoing archwire sequence as follows 0.014 inch NiTi 0.018 inch NiTi 0.020 inch NiTi 0.016x0.022 inch NiTi 0.019x0.025 inch NiTi
Device: Archwire
NiTi Archwires will be used for tooth alignment

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Speed of alignment
Time Frame: 6 months
Speed of alignment will be calculated in terms of number of visits and measured by Littles irregularity Index in millimeters
6 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Patient discomfort
Time Frame: 6 months
Will be measured as scoring on pain proforma on Visual analogue scale
6 months

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Root resorption
Time Frame: 6 months
Will be measured on periapical radiographs before and after alignment
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Foundation University Islamabad

Investigators

  • Study Chair: Shoaib Rahim, FCPS, FUCD & H
  • Study Chair: Rozina Nazir, FCPS, FUCD & H

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 20, 2024

Primary Completion (Actual)

July 2, 2025

Study Completion (Actual)

September 2, 2025

Study Registration Dates

First Submitted

August 6, 2026

First Submitted That Met QC Criteria

August 6, 2026

First Posted (Actual)

August 11, 2026

Study Record Updates

Last Update Posted (Actual)

August 13, 2026

Last Update Submitted That Met QC Criteria

August 11, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FUCDCLINIC-2403

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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