Minimally invasive comprehensive treatment for granulomatous lobular mastitis

Yaohuai Wang, Junlong Song, Yi Tu, Chuang Chen, Shengrong Sun, Yaohuai Wang, Junlong Song, Yi Tu, Chuang Chen, Shengrong Sun

Abstract

Objective: To describe a minimally invasive comprehensive treatment for granulomatous lobular mastitis (GLM) and compare its effect with the existing methods, particularly in terms of its recurrence rate and esthetic outcomes.

Methods: This retrospective study reviewed 69 GLM patients receiving the minimally invasive comprehensive treatment. Patients' information, including age, clinical features, image characteristics, histopathological findings, mastitis history, treatment process, operative technique, recurrence, and esthetic effect, was evaluated.

Results: All patients were female with a median age of 32 (range 17-55) years. Hospital stays ranged from 2 to 34 days, with a median of 6 days. The shortest time for complete rehabilitation was 2 days and the longest time was 365 days, with a median of 30 days. After a median follow-up of 391 days (range 162-690), 7 patients (10.14%) relapsed. The average cosmetic score was 2.62 ± 0.57 points and was mainly related to the past treatment, especially the surgical history.

Conclusion: Minimally invasive comprehensive treatment is a new method for the treatment of GLM, ensuring a therapeutic effect while maintaining breast beauty.

Keywords: Esthetic outcomes; Granulomatous lobular mastitis; Minimally invasive comprehensive treatment; Non-lactating mastitis; Recurrence rate.

Conflict of interest statement

The authors declare that #they have no competing interests.

Figures

Fig. 1
Fig. 1
The workflow of minimally invasive comprehensive treatment
Fig. 2
Fig. 2
Irrigation of lesions. Normal saline was injected into the lesion through the indwelling hoses. Please note that liquid is flowing out of the other indwelling hoses and surgical inlets, indicating that the indwelling hoses are unobstructed

References

    1. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol. 1972;58(6):642–646. doi: 10.1093/ajcp/58.6.642.
    1. Al Manasra AR, Al-Hurani MF. Granulomatous mastitis: a rare cause of male breast lump. Case Rep Oncol. 2016;9(2):516–519. doi: 10.1159/000448990.
    1. Velidedeoglu M, Kilic F, Mete B, Yemisen M, Celik V, Gazioglu E, et al. Bilateral idiopathic granulomatous mastitis. Asian J Surg. 2016;39(1):12–20. doi: 10.1016/j.asjsur.2015.02.003.
    1. Oddo D, Dominguez F, Gomez N, Mendez GP, Navarro ME. Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast. SAGE Open Med Case Rep. 2019;7:2050313x19836583.
    1. Zhou F, Yu L-X, Ma Z-B, Yu Z-G. Granulomatous lobular mastitis. Chronic Dis Transl Med. 2016;2(1):17–21. doi: 10.1016/j.cdtm.2016.02.004.
    1. Hladik M, Schoeller T, Ensat F, Wechselberger G. Idiopathic granulomatous mastitis: successful treatment by mastectomy and immediate breast reconstruction. J Plast Reconstr Aesthet Surg. 2011;64(12):1604–1607. doi: 10.1016/j.bjps.2011.07.011.
    1. Liu L, Zhou F, Zhang X, Liu S, Liu L, Xiang Y, et al. Granulomatous lobular mastitis: Antituberculous treatment and outcome in 22 patients. Breast Care. 2018;13(5):359–363. doi: 10.1159/000487935.
    1. Li J. Diagnosis and treatment of 75 patients with idiopathic lobular granulomatous mastitis. J Investig Surg. 2019;32(5):414–420. doi: 10.1080/08941939.2018.1424270.
    1. Chirappapha P, Thaweepworadej P, Supsamutchai C, Biadul N, Lertsithichai P. Idiopathic granulomatous mastitis: a retrospective cohort study between 44 patients with different treatment modalities. Ann Med Surg (Lond) 2018;36:162–167. doi: 10.1016/j.amsu.2018.11.001.
    1. Shin YD, Park SS, Song YJ, Son SM, Choi YJ. Is surgical excision necessary for the treatment of granulomatous lobular mastitis? BMC Womens Health. 2017;17(1):49. doi: 10.1186/s12905-017-0412-0.
    1. Freeman CM, Xia BT, Wilson GC, Lewis JD, Khan S, Lee SJ, et al. Idiopathic granulomatous mastitis: a diagnostic and therapeutic challenge. Am J Surg. 2017;214(4):701–706. doi: 10.1016/j.amjsurg.2017.07.002.
    1. Yabanoglu H, Colakoglu T, Belli S, Aytac HO, Bolat FA, Pourbagher A, et al. A comparative study of conservative versus surgical treatment protocols for 77 patients with idiopathic granulomatous mastitis. Breast J. 2015;21(4):363–369. doi: 10.1111/tbj.12415.
    1. Mahlab-Guri K, Asher I, Allweis T, Diment J, Sthoeger ZM, Mavor E. Granulomatous lobular mastitis. Isr Med Assoc J. 2015;17(8):476–480.
    1. Korkut E, Akcay MN, Karadeniz E, Subasi ID, Gursan N. Granulomatous mastitis: a ten-year experience at a university hospital. Eurasian J Med. 2015;47(3):165–173. doi: 10.5152/eurasianjmed.2015.118.
    1. Pandey TS, Mackinnon JC, Bressler L, Millar A, Marcus EE, Ganschow PS. Idiopathic granulomatous mastitis--a prospective study of 49 women and treatment outcomes with steroid therapy. Breast J. 2014;20(3):258–266. doi: 10.1111/tbj.12263.
    1. Karanlik H, Ozgur I, Simsek S, Fathalizadeh A, Tukenmez M, Sahin D, et al. Can steroids plus surgery become a first-line treatment of idiopathic granulomatous mastitis? Breast Care (Basel) 2014;9(5):338–342. doi: 10.1159/000366437.
    1. Al-Jarrah A, Taranikanti V, Lakhtakia R, Al-Jabri A, Sawhney S. Idiopathic granulomatous mastitis: diagnostic strategy and therapeutic implications in Omani patients. Sultan Qaboos Univ Med J. 2013;13(2):241–247. doi: 10.12816/0003229.
    1. Hovanessian Larsen LJ, Peyvandi B, Klipfel N, Grant E, Iyengar G. Granulomatous lobular mastitis: imaging, diagnosis, and treatment. AJR Am J Roentgenol. 2009;193(2):574–581. doi: 10.2214/AJR.08.1528.
    1. Lai EC, Chan WC, Ma TK, Tang AP, Poon CS, Leong HT. The role of conservative treatment in idiopathic granulomatous mastitis. Breast J. 2005;11(6):454–456. doi: 10.1111/j.1075-122X.2005.00127.x.
    1. Yu H-j, Deng H, Ma J, Huang S-J, Yang J-M, Huang Y-F, et al. Clinical metagenomic analysis of bacterial communities in breast abscesses of granulomatous mastitis. Int J Infect Dis. 2016;53:30–33. doi: 10.1016/j.ijid.2016.10.015.
    1. Taylor GB, Paviour SD, Musaad S, Jones WO, Holland DJ. A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology. 2003;35(2):109–119.
    1. Gambardella C, Clarizia G, Patrone R, Offi C, Mauriello C, Romano R, et al. Advanced hemostasis in axillary lymph node dissection for locally advanced breast cancer: new technology devices compared in the prevention of seroma formation. BMC Surg. 2019;18(Suppl 1):125. doi: 10.1186/s12893-018-0454-8.
    1. Conzo G, Tartaglia E, Avenia N, Calo PG, de Bellis A, Esposito K, et al. Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends. World J Surg Oncol. 2016;14:149. doi: 10.1186/s12957-016-0879-4.

Source: PubMed

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