Regression of brain metastases from breast cancer with eribulin: a case report

Hiromichi Matsuoka, Junji Tsurutani, Junko Tanizaki, Tsutomu Iwasa, Yoshifumi Komoike, Atsuko Koyama, Kazuhiko Nakagawa, Hiromichi Matsuoka, Junji Tsurutani, Junko Tanizaki, Tsutomu Iwasa, Yoshifumi Komoike, Atsuko Koyama, Kazuhiko Nakagawa

Abstract

Background: Eribulin is a recently approved new therapeutic option for patients with metastatic breast cancer. According to several reports, eribulin has limited ability to cross the blood brain barrier. Recently, capecitabine and eribulin have been recognized as drugs with similar application for patients with advanced breast cancer. Although there have been several case reports describing the efficacy of capecitabine against brain metastases, no report of eribulin demonstrating efficacy for brain metastases exists today.

Case presentation: We describe a case of a 57-year-old Japanese woman who was diagnosed with breast cancer stage IV metastasized to multiple organs including liver and lung. After she received 3 regimens, she showed evidence of brain metastases, and whole brain radiation therapy was performed. Lapatinib and capecitabine was then administered as fourth-line chemotherapy, but the patient was hospitalized due to the exacerbation of interstitial pneumonitis and progression of brain and liver metastases. To control the systemic disease, eribulin was commenced as fifth-line chemotherapy. One month later, a significant response of brain metastases had been achieved, and this response has persisted for the last 4 months. We now describe a remarkable antitumor effect of eribulin against brain metastases from breast cancer. This case is the first report which indicates potential treatment of brain metastases using this medication.

Conclusion: This report suggests that eribulin treatment may be beneficial for breast cancer patients with brain metastases progressing after whole brain radiation therapy. However, further clinical studies are warranted to determine the clinical effect of eribulin in brain metastases.

Figures

Figure 1
Figure 1
The first evidence of brain metastases. After 6 cycles of the 3rd-line chemotherapy, the first evidence of brain metastases was shown. The arrow indicates appearance of the new metastatic lesion.
Figure 2
Figure 2
The effect of whole brain radiation therapy. After whole brain radiation therapy, tumor regression was observed.
Figure 3
Figure 3
Regrowth of the brain metastases. 4th-line chemotherapy was administered, but patient was hospitalized again. Regrowth of the brain metastases was detected. The arrow indicates the recurrent tumor.
Figure 4
Figure 4
The effect of eribulin. After the administration of eribulin, a significant response of brain metastases had been achieved. The arrow indicates disappearance of the recurrent tumor.

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