Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial

Abstract

Objective: To test the hypothesis that environmental compared with nasal cannula oxygen decreases episodes of intermittent hypoxemia (oxygen saturations <85% for ≥10 seconds) in preterm infants on supplemental oxygen by providing a more stable hypopharyngeal oxygen concentration.

Study design: This was a single center randomized crossover trial with a 1:1 parallel allocation to order of testing. Preterm infants on supplemental oxygen via oxygen environment maintained by a servo-controlled system or nasal cannula with flow rates ≤1.0 L per kg per minute were crossed over every 24 hours for 96 hours. Data were collected electronically to capture real time numeric and waveform data from patient monitors.

Results: Twenty-five infants with gestational age of 27 ± 2 weeks (mean ± SD) and a birth weight of 933 ± 328 g were studied at postnatal day 36 ± 26. The number of episodes of intermittent hypoxemia per 24 hours was 117 ± 77 (median, 98; range, 4-335) with oxygen environment vs 130 ± 63 (median, 136; range, 16-252) with nasal cannula (P = .002). Infants on oxygen environment compared with nasal cannula also had decreased episodes of severe intermittent hypoxemia (P = .005). Infants on oxygen environment compared with nasal cannula had a lower proportion of time with oxygen saturations <85% (.05 ± .03 vs .06 ± .03, P < .001), and a lower coefficient of variation of oxygen saturation (P = .02).

Conclusions: In preterm infants receiving supplemental oxygen, servo-controlled oxygen environment decreases hypoxemia compared with nasal cannula.

Trial registration: ClinicalTrials.gov: NCT02794662.

Keywords: bronchopulmonary dysplasia; incubator; infant; intermittent hypoxemia; neonatal; neonate; newborn; respiratory distress syndrome; servo-controlled; supplemental.

Copyright © 2018 Elsevier Inc. All rights reserved.

Figures

Figure 1

Flow diagram showing screening, randomization, and the number of infants included in the final data analysis. OE = oxygen environment; NC = nasal cannula

Figure 2

Box plot with whiskers showing the proportion of time with oxygen saturations less than 85% on oxygen environment (OE) versus nasal cannula (NC). Infants on oxygen environment had oxygen saturations