Interamerican Society of Cardiology (IASC) position statement: Chlorthalidone vs. thiazide- type diuretics
Anil Pareek, Franz H Messerli, Gustavo Saravia, Ravi Tejraj Mehta, Anil Pareek, Franz H Messerli, Gustavo Saravia, Ravi Tejraj Mehta
Abstract
The Interamerican Society of Cardiology (IASC) Position Statement for hypertension management in Latin America is a practical and useful review of five different hypertension guidelines. Though, thiazide diuretics have been recommended as firstline option, the position statement needs to highlight differences within the thiazide class. Chlorthalidone is structurally and pharmacokinetically distinct from thiazide-type iuretics like hydrochlorothiazide with a longer half-life and 24-h anti-hypertensive effect. It has been shown to reduce cardiovascular morbidity and mortality in several landmark studies evaluating anti-hypertensives.
Keywords: CTD, chlorthalidone; CV, cardiovascular; Chlorthalidone; Guidelines; HCTZ, hydrochlorothiazide; Hydrochlorothiazide; Hypertension; IASC, Interamerican Society of Cardiology; Thiazide diuretics; Thiazide-like diuretics.
Conflict of interest statement
Dr. Anil Pareek and Dr. Ravi Tejraj Mehta are employees of Ipca Laboratories Ltd., India and involved in clinical research on anti-hypertensives including chlorthalidone. Dr. Franz H. Messerli declares no relevant conflicts of interest in relation to this manuscript. Dr. Gustavo Saravia declares having advisory relationships and receiving honoraria from AstraZeneca and Ipca Laboratories Limited. No funding is involved in writing this manuscript.
© 2020 The Authors.
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Source: PubMed