Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami

Abstract

Background: HIV and HCV infections are both characterized by increased oxidative stress. Information on the magnitude of this increase and its consequences in HIV/HCV co-infection and viral replication is limited. We investigated the relationship between oxidative stress and HIV-progression in HIV/HCV co-infected and HIV mono-infected adults.

Methods: 106 HIV/HCV co-infected and 115 HIV mono-infected participants provided demographic information and blood to determine 8-oxo-dG and percent oxidized glutathione.

Results: HIV/HCV co-infected subjects had higher percent oxidized glutathione, higher HIV viral load, lower mtDNA copies and higher liver fibrosis than mono-infected subjects. In a small sample of HIV/HCV co-infected participants with liver biopsy, 8-oxo-dG was significantly lower in participants with low fibrosis scores than those with high fibrosis scores, and the grade of inflammation was strongly associated with oxidized glutathione.

Conclusions: HIV/HCV co-infection seems to diminish the capacity of the antioxidant system to control oxidative stress, and increases HIV replication.

Keywords: Glutathione (GSH); HIV/HCV co-infection; liver fibrosis index (FIB-4); oxidative stress.

Figures

Fig. 1. Correlation of liver disease progression with HIV viral load and oxidative stress

Figure 1 indicates correlation between liver fibrosis and HIV viral load

Fig. 2. Correlation of liver disease progression with HIV viral load and oxidative stress

figure 2 represents correlation between liver fibrosis and oxidized GSSG level.