Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials

Dayna R Clark, Saad B Omer, Milagritos D Tapia, Marta C Nunes, Clare L Cutland, James M Tielsch, Niteen Wairagkar, Shabir A Madhi, for BMGF Supported Maternal Influenza Immunization Trials Investigators Group, Dayna R Clark, Saad B Omer, Milagritos D Tapia, Marta C Nunes, Clare L Cutland, James M Tielsch, Niteen Wairagkar, Shabir A Madhi, for BMGF Supported Maternal Influenza Immunization Trials Investigators Group

Abstract

This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.

Conflict of interest statement

Dr. Omer and Ms. Clark serve as consultants to the Bill & Melinda Gates Foundation and received compensation for these services. Original trials were funded by the Bill & Melinda Gates Foundation. We declare no additional competing interests.

Figures

FIGURE 1.
FIGURE 1.
Positive Meningococcal Cultures in Bamako, Mali, and Mali Monthly Deaths by Study Arm.

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