Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic

C M Chu, C T Yeh, C T Chiu, I S Sheen, Y F Liaw, C M Chu, C T Yeh, C T Chiu, I S Sheen, Y F Liaw

Abstract

By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.

References

    1. J Virol. 1990 Mar;64(3):1298-303
    1. J Infect Dis. 1995 Apr;171(4):776-81
    1. Gastroenterology. 1991 Apr;100(4):1087-94
    1. Nucleic Acids Res. 1991 Apr 11;19(7):1427-30
    1. N Engl J Med. 1991 Jun 13;324(24):1699-704
    1. N Engl J Med. 1991 Jun 13;324(24):1705-9
    1. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4186-90
    1. Hepatology. 1991 Aug;14(2):219-22
    1. Gut. 1976 Jan;17(1):10-13
    1. Br Med J. 1976 Sep 18;2(6037):669-71
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7
    1. Hepatology. 1985 May-Jun;5(3):431-4
    1. Liver. 1988 Aug;8(4):231-5
    1. Hepatology. 1989 Mar;9(3):452-6
    1. Lancet. 1989 Sep 9;2(8663):588-91
    1. Virology. 1992 Mar;187(1):271-9
    1. Hepatology. 1992 Jul;16(1):31-5
    1. J Hepatol. 1993 Apr;18(1):119-22
    1. Gastroenterology. 1993 Oct;105(4):1173-8
    1. Dig Dis Sci. 1994 Jun;39(6):1281-7
    1. Gastroenterology. 1994 Jul;107(1):189-95
    1. J Infect Dis. 1994 Dec;170(6):1582-5
    1. Infection. 1990 Jul-Aug;18(4):200-3

Source: PubMed

Sponsors and Collaborators

Medical Conditions

Drug Interventions

3
Subscribe