Point-of-care Arkansas method for measuring adherence to treatment with isoniazid
Renata L Guerra, Marcus B Conde, Anne Efron, Carla Loredo, Gisele Bastos, Richard E Chaisson, Jonathan E Golub, Renata L Guerra, Marcus B Conde, Anne Efron, Carla Loredo, Gisele Bastos, Richard E Chaisson, Jonathan E Golub
Abstract
We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.
Conflict of interest statement
Conflict of interest
The authors have no conflict of interest. The study sponsors had no involvement in the study design, data collection, analysis and interpretation, writing of the manuscript, and in the decision to submit the manuscript for publication.
Source: PubMed