Acne Scarring-Pathogenesis, Evaluation, and Treatment Options

Deirdre Connolly, Ha Linh Vu, Kavita Mariwalla, Nazanin Saedi, Deirdre Connolly, Ha Linh Vu, Kavita Mariwalla, Nazanin Saedi

Abstract

Acne vulgaris is a ubiquitous problem affecting 80 percent of people ages 11 to 30 years, with many patients experiencing some degree of scarring. This review focuses on atrophic scars, the most common type of acne scar. We briefly address the cellular sequelae that lead to scar formation and the initial evaluation of patients with acne scars. We then discuss an algorithmic approach to the treatment of acne scarring based on the classification of scars into erythematous and atrophic types. Lastly, we discuss the future treatment of acne scars and ongoing clinical trials.

Keywords: Acne scarring; acne; acne vulgaris; laser; light devices; resurfacing agents.

Conflict of interest statement

FUNDING:No funding was provided for this study. DISCLOSURES:The authors have no conflicts of interest relating to the content of this article.

Figures

FIGURE 1.
FIGURE 1.
The three types of atrophic acne scars: A) icepick, B) boxcar, and C) rolling
FIGURE 2.
FIGURE 2.
Acne scarring treatment algorithm

References

    1. Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001;45:109–117.
    1. Kang S, Cho S, Chung JH, et al. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo. Am J Pathol. 2005;166:1691–1699.
    1. Layton AM. Optimal management of acne to prevent scarring and psychological sequelae. Am J Clin Dermotol. 2001;2:135–141.
    1. Kircik LH. Re-evaluating treatment targets in acne vulgaris: adapting to a new understanding of pathophysiology. J Drugs Dermatol. 2014;13:s57–60.
    1. Davis EC, Callender VD. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. J Clin Aesthet Dermatol. 2010;3:20–31. Jul.
    1. Vowels BR, Yang S, Leyden JJ. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. InfectImmun. 1995;63:3158–3165.
    1. Bae-Harboe YS, Graber EM. Easy as PIE (Postinflammatory Erythema) J Clin Aesthet. Dermatol. 2013;6:46–47.
    1. Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clin Exp Dermatol. 1994;19:303–308.
    1. Layton AM, Seukeran D, Cunliffe WJ. Scarred for life? Dermatology. 1997;195(Suppl 1):15–21.
    1. Goodman GJ. Management of post-acne scarring. What are the options for treatment? Am J Clin Dermatol. 2000;1:3–17.
    1. Lee WJ, Jung HJ, Lim HJ, et al. Serial sections of atrophic acne scars help in the interpretation of microscopic findings and the selection of good therapeutic modalities. J Eur Acad Dermatol. Venereol. 2013;27:643–646.
    1. Jasson F, Nagy I, Knol AC, et al. Different strains of Propionibacterium acnes modulate differently the cutaneous innate immunity. Exp Dermatol. 2013;22:587–592.
    1. Holland DB, Jeremy AH, Roberts SG, et al. Inflammation in acne scarring: a comparison of the responses in lesions from patients prone and not prone to scar. Br J Dermatol. 2004;150:72–81.
    1. Saint-Jean M, Khammari A, Jasson F, et al. Different cutaneous innate immunity profiles in acne patients with and without atrophic scars. Eur J Dermatol. 2016;26:68–74.
    1. Abdel HR, Shalaby K, Zaber H, et al. Interventions for acne scars. Coch Data Systemat Rev. 2016;4:CD011946
    1. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379:361–372.
    1. Alster TS, McMeekin TO. Improvement of facial acne scars by the 585 nm flashlamp-pumped pulsed dye laser. J Am Acad Dermatol. 1996;35:79–81.
    1. Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220:524–527.
    1. Iyer S, Fitzpatrick RE. Long-pulsed dye laser treatment for facial telangiectasias and erythema: evaluation of a single purpuric pass versus multiple subpurpuric passes. Dermatol Surg. 2005;31:898–903.
    1. Patel N, Clement M. Selective nonablative treatment of acne scarring with 585 nm flashlamp pulsed dye laser. Dermatol Surg. 2002;28:942–945.
    1. Lee DH, Choi YS, Min SU, et al. Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: a randomized split-face clinical study. J Am Acad Dermatol. 2009;60:801–807.
    1. Seaton ED, Mouser PE, Charakida A, et al. Investigation of the mechanism of action of nonablative pulsed-dye laser therapyin photorejuvenation and inflammatory acne vulgaris. Br J Dermatol. 2006;155:748–755.
    1. Park KY, Ko EJ, Seo SJ, Hong CK. Comparison of fractional, nonablative, 1550-nm laser and 595-nm pulsed dye laser for the treatment of facial erythema resulting from acne: a split-face, evaluator-blinded, randomized pilot study. J Cosmet Laser Ther. 2014;16:120–123.
    1. Glaich AS, Goldberg LH, Friedman RH, Friedman PM. Fractional photothermolysis for the treatment of postinflammatory erythema resulting from acne vulgaris. Dermatol Surg. 2007;33:842–846.
    1. Cartier H. Use of intense pulsed light in the treatment of scars. J Cosmet Dermatol. 2005;4:34–40.
    1. Keaney TC, Tanzi E, Alster T. Comparison of 532 nm potassium titanyl phosphate laser and 595 nm pulsed dye laser in the treatment of erythematous surgical scars: a randomized, controlled, open-label study. Dermatol Surg. 2016;42:70–76.
    1. Cohen BE, Brauer JA, Geronemus RG. Acne scarring: A review of available therapeutic lasers. Lasers Surg Med. 2016;48:95–115.
    1. Rao J. Treatment of acne scarring. Facial Plast Surg Clin North Am. 2011;19:275–291.
    1. Min SU, Choi YS, Lee DH, et al. Comparison of a long-pulse Nd:YAG laser and a combined 585/1,064-nm laser for the treatment of acne scars: a randomized split-face clinical study. Dermatol Surg. 2009;35:1720–1727.
    1. Sadick NS, Weiss R. Intense pulsed-light photorejuvenation. Semin Cutan Med Surg. 2002;21:280–287.
    1. Bjerring P, Christiansen K, Troilius A, Dierickx C. Facial photo rejuvenation using two different intense pulsed light (IPL) wavelength bands. Lasers Surg Med. 2004;34:120–126.
    1. Rivera AE. Acne scarring: a review and current treatment modalities. J Am Acad Dermatol. 2008;59:659–676.
    1. Metelitsa Al, Alster TS. Fractionated laser skin resurfacing treatment complications: a review. Dermatol Surg. 2010;36:299–306.
    1. Walia S, Alster TS. Prolonged clinical and histologic effects from CO2 laser resurfacing of atrophic acne scars. Dermatol Surg. 1999;25:926–930.
    1. Brightman LA, Brauer JA, Anolik R, et al. Ablative and fractional ablative lasers. Dermatol Clin. 2009;27:479–489.
    1. Alster T, Hirsch R. Single-pass CO2 laser skin resurfacing of light and dark skin: extended experience with 52 patients. J Cosmet Laser Ther. 2003;5:39–42.
    1. Tanzi EL, Alster TS. Treatment of atrophic facial acne scars with a dual-mode Er:YAG laser. Dermatol Surg. 2002;28:551–555.
    1. Walsh JT, Jr, Flotte TJ, Deutsch TF. Er:YAG laser ablation of tissue: effect of pulse duration and tissue type on thermal damage. Lasers Surg Med. 1989;9:314–326.
    1. Alster TS. Cutaneous resurfacing with CO2 and erbium: YAG lasers: preoperative, intraoperative, and postoperative considerations. Plast Reconstr Surg. 1999;103:619–634.
    1. Jeong JT, Kye YC. Resurfacing of pitted facial acne scars with a long-pulsed Er:YAG laser. Dermatol Surg. 2001;27:107–110.
    1. Hu S, Gold MH. Treatment of facial acne scars in Asian skin with the single-spot, 2940-nm Er:YAG dual-mode laser. J Drugs Dermatol. 2010;9:1341–1344.
    1. Wanitphakdeedecha R, Manuskiatti W, Siriphukpong S, Chen TM. Treatment of punched-out atrophic and rolling acne scars in skin phototypes III, IV, and V with variable square pulse erbium:yttrium-aluminum-garnet laser resurfacing. Dermatol Surg. 2009;35:1376–1383.
    1. Woo SH, Park JH, Kye YC. Resurfacing of different types of facial acne scar with short-pulsed, variable-pulsed, and dual-mode Er:YAG laser. Dermatol Surg. 2004;30:488–493.
    1. Tanzi EL, Alster TS. Single-pass carbon dioxide versus multiple-pass Er:YAG laser skin resurfacing: a comparison of postoperative wound healing and side-effect rates. Dermatol Surg. 2003;29:80–84.
    1. Tanzi EL, Alster TS. Comparison of a 1450-nm diode laser and a 1320-nm Nd:YAG laser in the treatment of atrophic facial scars: a prospective clinical and histologic study. Dermatol Surg. 2004;30:152–157.
    1. Abraham MT, Vic Ross E. Current concepts in nonablative radiofrequency rejuvenation of the lower face and neck. Facial Plast Surg. 2005;21:65–73.
    1. Tierney EP, Eisen RF, Hanke CW. Fractionated CO2 laser skin rejuvenation. Dermatol Ther. 2011;24:41–53.
    1. Maluki AH, Mohammad FH. Treatment of atrophic facial scars of acne vulgaris by Q-Switched Nd:YAG (Neodymium: Yttrium-Aluminum-Garnet) laser 1064nm wavelength. J Cosmet Laser Ther. 2012;14:224–233.
    1. Goldberg DJ, Silapunt S. Q-switched Nd:YAG laser: rhytid improvement by non-ablative dermal remodeling. J Cutan Laser Ther. 2000;2:157–160.
    1. Prieto VG, Zhang PS, Sadick NS. Evaluation of pulsed light and radiofrequency combined for the treatment of acne vulgaris with histologic analysis of facial skin biopsies. J Cosmet Laser Ther. 2005;7:63–68.
    1. Upper GM, Perez M. Nonablative acne scar reduction after a series of treatments with a short-pulsed 1,064-nm neodymium:YAG laser. Dermatol Surg. 2006;32:998–1006.
    1. Alam M, Hsu TS, Dover JS, et al. Nonablative laser and light treatments: histology and tissue effects—a review. Lasers Surg Med. 2003;33:30–39.
    1. Friedman PM, Jih MH, Skover GR, et al. Treatment of atrophic facial acne scars with the 1064-nm Q-switched Nd:YAG laser: six-month follow-up smdy. Arch Dermatol. 2004;140:1337–1341.
    1. Bellew SG, Lee C, Weiss MA, Weiss RA. Improvement of atrophic acne scars with a 1,320 nm Nd:YAG laser: retrospective study. Dermatol Surg. 2005;31:1218–1222.
    1. Bhatia AC, Dover JS, Arndt KA, et al. Patient satisfaction and reported long-term therapeutic efficacy associated with 1,320 m Nd:YAG laser treatment of acne scarring and photoaging. Dermotol Surg. 2006;32:346–352.
    1. Wada T, Kawada A, Hirao A, et al. Efficacy and safety of a low-energy double-pass 1450-nm diode laser for the treatment of acne scars. Photomed Laser Surg. 2012;30:107–111.
    1. Yaghmai D, Garden JM, Bakus AD, Massa MC. Comparison of a 1,064 nm laser and a 1,320 nm laser for the nonablative treatment of acne scars. Dermatol Surg. 2005;31:903–909.
    1. Chua SH, Ang P, Khoo LS, Goh CL. Nonablative 1450-nm diode laser in the treatment of facial atrophic acne scars in type IV to V Asian skin: a prospective clinical study. Dermatol Surg. 2004;30:1287–1291.
    1. Rogachefsky AS, Hussain M, Goldberg DJ. Atrophic and a mixed pattern of acne scars improved with a 1320-nm Nd:YAG laser. Dermatol Surg. 2003;29:904–908.
    1. Tanzi EL, Williams CM, Alster TS. Treatment of facial rhytides with a nonablative 1,450-nm diode laser: a controlled clinical and histologic study. Dermatol Surg. 2003;29:124–128.
    1. Ong MW, Bashir SJ. Fractional laser resurfacing for acne scars: a review. Br J Dermatol. 2012;166:1160–1169.
    1. Hedelund L, Moreau KE, Beyer DM, et al. Fractional nonablative 1,540-nm laser resurfacing of atrophic acne scars, a randomized controlled trial with blinded response evaluation. Lasers Med Sci. 2010;25:749–754.
    1. Bencini PL, Jourlaki A, Galimberti M, et al. Nonablative fractional photothermolysis for acne scars: clinical and in vivo microscopic documentation of treatment efficacy. Dermatol Ther. 2012;25:463–467.
    1. Yoo KH, Ahn JY, Kim JY, et al. The use of 1540 nm fractional photothermolysis for the treatment of acne scars in Asian skin: a pilot study. Photodermatol Photoimmunol Photomed. 2009;25:138–142.
    1. Sardana K, Manjhi M, Garg VK, Sagar V. Which type of atrophic acne scar (ice-pick, boxcar, or rolling) responds to nonablative fractional laser therapy? Dermatol Surg. 2014;40:288–300.
    1. Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg. 2007;33:295–299.
    1. Chrastil B, Glaich AS, Goldberg LH, Friedman PM. Second-generation 1,550-nm fractional photothermolysis for the treatment of acne scars. Dermatol Surg. 2008;34:1327–1332.
    1. Chan NP, Ho SG, Yeung CK, et al. The use of nonablative fractional resurfacing in Asian acne scar patients. Lasers Surg Med. 2010;42:710–715.
    1. Chapas AM, Brightman L, Sukal S, et al. Successful treatment of acneiform scarring with C2 ablative fractional resurfacing. Lasers Surg. Med. 2008;40:381–386.
    1. Jung JY, Lee JH, Ryu DJ, et al. Lower-fluence, higher-density versus higher-fluence, lower-density treatment with a 10,600-nm carbon dioxide fractional laser system: a split-face, evaluator-blinded study. Dermatol Surg. 2010;36:2022–2029.
    1. Asilian A, Salimi E, Faghihi G, et al. Comparison of Q-Switched 1064-nm Nd:YAG laser and fractional CO2 laser efficacies on improvement of atrophic facial acne scar. J Res Med Sci. 2011;16:1189–1195.
    1. Cho SB, Lee SJ, Kang JM, et al. The efficacy and safety of 10,600-nm carbon dioxide fractional laser for acne scars in Asian patients. Dermatol Surg. 2009;35:1955–1961.
    1. Kim S. Treatment of acne scars in Asian patients using a 2,790-nm fractional yttrium scandium gallium garnet laser. Dermatol Surg. 2011;37:1464–1469.
    1. Zhu JT, Xuan M, Zhang YN, et al. The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne. Mol Med Rep. 2013;8:233–237.
    1. Hirsch RJ, Lewis AB. Treatment of acne scarring. Semin Cutan Med Surg. 2001;20:190–198.
    1. You HJ, Kim DW, Yoon ES, Park SH. Comparison of four different lasers for acne scars: Resurfacing and fractional lasers. J Plast Reconstr Aesthet Surg. 2016;69:e87–95.
    1. Frank W. Therapeutic dermabrasion, back to the future. Arch Dermatol. 1994;130:1187–1189.
    1. Moy LS, Kotler R, Lesser T. The histologic evaluation of pulsed carbon dioxide laser resurfacing versus phenol chemical peels in vivo. Dermatol Surg. 1999;25:597–600.
    1. Garg VK, Sinha S, Sarkar R. Glycolicacid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. Dermatol Surg. 2009;35:59–65.
    1. Al-Waiz MM, Al-Sharqi Al. Medium-depth chemical peels in the treatment of acne scars in dark-skinned individuals. Dermatol Surg. 2002;28:383–387.
    1. Nikalji N, Godse K, Sakhiya J, et al. Complications of medium depth and deep chemical peels. J Cutan Aesthet Surg. 2012;5:254–260.
    1. Landau M. Cardiac complications in deep chemical peels. Dermatol Surg. 2007;33:190–193.
    1. Fabbrocini G, Annunziata MC, D’Arco V, et al. Acne scars: pathogenesis, classification and treatment. Dermatol Res Pract. 2010;2010:893080.
    1. Kim HJ, Kim TG, Kwon YS, et al. Comparison of a 1,550 nm Erbium: glass fractional laser and a chemical reconstruction of skin scars (CROSS) method in the treatment of acne scars: a simultaneous split-face trial. Lasers Surg Med. 2009;41:545–549.
    1. Nofal E, Helmy A, Nofal A, et al. Platelet-rich plasma versus CROSS technique with 100% trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study. Dermatol Surg. 2014;40:864–873.
    1. Simmons BJ, Griffith RD, Falto-Aizpurua LA, Nouri K. Use of radiofrequency in cosmetic dermatology: focus on nonablative treatment of acne scars. Clin Cosmet Investig Dermatol. 2014;7:335–339.
    1. Lolis MS, Goldberg DJ. Radiofrequency in cosmetic dermatology: a review. Dermatol Surg. 2012;38:1765–1776.
    1. Min S, Park SY, Yoon JY, Suh DH. Comparison of fractional microneedling radiofrequency and bipolar radiofrequency on acne and acne scar and investigation of mechanism: comparative randomized controlled clinical trial. Arch Dermatol Res. 2015;307:897–904.
    1. Wollina U, Goldman A. Fillers for the improvement in acne scars. Clin Cosmet Investig Dermatol. 2015;8:493–499.
    1. Hasson A, Romero WA. Treatment of facial atrophic scars with Esthelis, a hyaluronic acid filler with polydense cohesive matrix (CPM) J Drugs Dermatol. 2010;9:1507–1509.
    1. Halachmi S, Ben Amitai D, Lapidoth M. Treatment of acne scars with hyaluronic acid: an improved approach. J Drugs Dermatol. 2013;12:e121–123.
    1. Kalantar-Hormozi A, Mozafari N, Rasti M. Adverse effects after use of Polyacrylamide gel as a facial soft tissue filler. Aesthet Surg J. 2008;28:139–142.
    1. Sadove R. Injectable poly-L: -lactic acid: a novel sculpting agent for the treatment of dermal fat atrophy after severe acne. Aesthetic Plast Surg. 2009;33:113–116.
    1. Jacovella PF. Use of calcium hydroxylapatite (Radiesse) for facial augmentation. Clin Interv Aging. 2008;3:161–174.
    1. Goldberg DJ, Amin S, Hussain M. Acne scar correction using calcium hydroxylapatite in a carrier-based gel. J Cosmet Laser Ther. 2006;8:134–136.
    1. De Boulle K, Heydenrych I. Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol. 2015;8:205–214.
    1. Epstein RE, Spencer JM. Correction of atrophic scars with artefill: an open-label pilot study. J Drugs Dermatol. 2010;9:1062–1064.
    1. Karnik J, Baumann L, Bruce S, et al. A double-blind, randomized, multicenter, controlled trial of suspended polymethylmethacrylate microspheres for the correction of atrophic facial acne scars. J Am Acad Dermatol. 2014;71:77–83.
    1. Fife D. Practical evaluation and management of atrophic acne scars: tips for the general dermatologist. J Clin Aesthet Dermatol. 2011;4:50–57.
    1. Goodman GJ, Baron JA. The management of postacne scarring. Dermatol Surg. 2007;33:1175–1188.
    1. Alam M, Omura N, Kaminer MS. Subcision for acne scarring: technique and outcomes in 40 patients. Dermatol Surg. 2005;31:310–317.
    1. Orentreich DS, Orentreich N. Subcutaneous incisionless (subcision) surgery for the correction of depressed scars and wrinkles. Dermatol Surg. 1995;21:543–549.
    1. Nilforoushzadeh M, Lotfi E, Nickkholgh E, et al. Can subcision with the cannula be an acceptable alternative method in treatment of acne scars? Med Arch. 2015;69:384–386.
    1. Lee JB, Chung WG, Kwahck H, Lee KH. Focal treatment of acne scars with trichloroacetic acid: chemical reconstruction of skin scars method. Dermatol Surg. 2002;28:1017–1021.
    1. AgarwaI N, Gupta LK, Khare AK, et al. Therapeutic response of 70% trichloroacetic acid CROSS in atrophic acne scars. Dermatol Surg. 2015;41:597–604.
    1. Del Rosso JQ, Kircik LH. The sequence of inflammation, relevant biomarkers, and the pathogenesis of acne vulgaris: what does recent research show and what does it mean to the clinician? J Drugs Dermatol. 2013;12:s109–115.
    1. He L, Wu WJ, Yang JK, et al. Two new susceptibility loci 1 q24.2 and 11 p 11.2 confer risk to severe acne. Nat Commun. 2014;5:2870.
    1. Carter CA, Jolly DG, Worden CES, et al. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 2003;74:244–255.
    1. Gardner MJ, Demetrakopoulos D, Klepchick PR, Mooar PA. The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. an analysis of the haemoglobin, narcotic requirement and range of motion. Int Orthop. 2007;31:309–313.
    1. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118:147e–159e.
    1. Redaelli A, Romano D, Marciano A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010;9:466–472.
    1. Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. Dermatol Surg. 2011;37:931–938.
    1. Gawdat HI, Hegazy RA, Fawzy MM, Fathy M. Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg. 2014;40:152–161.
    1. Nie C, Yang D, Xu J, et al. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant. 2011;20:205–216.
    1. Doi H, Kitajima Y, Luo L, et al. Potency of umbilical cord blood-and Wharton’s jelly-derived mesenchymal stem cells for scarless wound healing. Sci Rep. 2016;6:18844.
    1. Brauer JA, Kazlouskaya V, Alabdulrazzaq H, et al. Use of a picosecond pulse duration laser with specialized optic for treatment of facial acne scarring. JAMA Dermatol. 2015;151:278–284.
    1. Tanghetti EA. The histology of skin treated with a picosecond alexandrite laser and a fractional lens array. Lasers Surg Med. 2016;48:646–652.
    1. Dogra S, Yadav S, Sarangal R. Microneedling for acne scars in Asian skin type: an effective low cost treatment modality. J Cosmet Dermatol. 2014;13:180–187.
    1. Asif M, Kanodia S, Singh K. Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study. J Cosmet Dermatol. 2016;15:434–443.
    1. Cachafeiro T, Escobar G, Maldonado G, et al. Comparison of nonablative fractional erbium laser 1,340 nm and microneedling for the treatment of atrophic acne scars: a randomized clinical trial. Dermatol Surg. 2016;42:232–241.
    1. Fife DJ1, Fitzpatrick RE, Zachary CB. Complications of fractional CO2 laser resurfacing: fourcases. Lasers Surg Med. 2009;41(3):179–184.

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