Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest

Katarina Heimburg, Tobias Cronberg, Åsa B Tornberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Christian Hassager, Janneke Horn, Jesper Kjærgaard, Michael Kuiper, Christian Rylander, Matt P Wise, Gisela Lilja, Katarina Heimburg, Tobias Cronberg, Åsa B Tornberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Christian Hassager, Janneke Horn, Jesper Kjærgaard, Michael Kuiper, Christian Rylander, Matt P Wise, Gisela Lilja

Abstract

Title: Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest.

Background: Out-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.

Aims: To describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) controls, matched for country, age, sex and time of the cardiac event. A second aim was to explore variables potentially associated with self-reported limitations in physical function in OHCA survivors.

Methods: A cross-sectional sub-study of the Targeted Temperature Management at 33 °C versus 36 °C (TTM) trial with a follow-up 6 months post-event. Physical function was the main outcome assessed with the self-reported Physical Functioning-10 items scale (PF-10). PF-10 is presented as T-scores (0-100), where 50 represents the norm mean. Scores <47 at a group level, or <45 at an individual level indicate limitations in physical function.

Results: 287 OHCA survivors and 119 STEMI controls participated. Self-reported physical function by PF-10 was significantly lower for OHCA survivors compared to STEMI controls (mean 46.0, SD 11.2 vs. 48.8, SD 9.0, p = 0.025). 38% of OHCA survivors compared to 26% of STEMI controls reported limitations in physical function at an individual level (p = 0.022). The most predictive variables for self-reported limitations in physical function in OHCA survivors were older age, female sex, cognitive impairment, and symptoms of anxiety and depression after 6 months.

Conclusion: Self-reported limitations in physical function are more common in OHCA survivors compared to STEMI controls.

Trial registration: ClinicalTrials.gov Identifier: NCT01946932.

Keywords: Cardiac Arrest; Myocardial Infarction; Patient Reported Outcome Measures; Physical Function.

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

© 2022 The Author(s).

Figures

Fig. 1
Fig. 1
Flowchart for inclusion. Abbreviations denote: PF-10 = Physical Functioning-10 items scale, OHCA = out-of-hospital cardiac arrest, STEMI = ST elevation myocardial infarction.

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