Effects of intra-resuscitation antiarrhythmic administration on rearrest occurrence and intra-resuscitation ECG characteristics in the ROC ALPS trial

Abstract

Background: Intra-resuscitation antiarrhythmic drugs may improve resuscitation outcomes, in part by avoiding rearrest, a condition associated with poor out-of-hospital cardiac arrest (OHCA) outcomes. However, antiarrhythmics may also alter defibrillation threshold. The objective of this study was to investigate the relationship between rearrest and intra-resuscitation antiarrhythmic drugs in the context of the Resuscitation Outcomes Consortium (ROC) amiodarone, lidocaine, and placebo (ALPS) trial.

Hypothesis: Rearrest rates would be lower in cases treated with amiodarone or lidocaine, versus saline placebo, prior to first return of spontaneous circulation (ROSC). We also hypothesized antiarrhythmic effects would be quantifiable through analysis of the prehospital electrocardiogram.

Methods: We conducted a secondary analysis of the ROC ALPS trial. Cases that first achieved prehospital ROSC after randomized administration of study drug were included in the analysis. Rearrest, defined as loss of pulses following ROSC, was ascertained from emergency medical services records. Rearrest rate was calculated overall, as well as by ALPS treatment group. Multivariable logistic regression models were constructed to assess the association between treatment group and rearrest, as well as rearrest and both survival to hospital discharge and survival with neurologic function. Amplitude spectrum area, median slope, and centroid frequency of the ventricular fibrillation (VF) ECG were calculated and compared across treatment groups.

Results: A total of 1144 (40.4%) cases with study drug prior to first ROSC were included. Rearrest rate was 44.0% overall; 42.9% for placebo, 45.7% for lidocaine, and 43.0% for amiodarone. In multivariable logistic regression models, ALPS treatment group was not associated with rearrest, though rearrest was associated with poor survival and neurologic outcomes. AMSA and median slope measures of the first available VF were associated with rearrest case status, while median slope and centroid frequency were associated with ALPS treatment group.

Conclusion: Rearrest rates did not differ between antiarrhythmic and placebo treatment groups. ECG waveform characteristics were correlated with treatment group and rearrest. Rearrest was inversely associated with survival and neurologic outcomes.

Keywords: Amiodarone; Arrhythmia; Cardiac arrest; Electrocardiogram; Lidocaine; Resuscitation.

Copyright © 2018 Elsevier B.V. All rights reserved.

Figures

Figure 1.. Survival and Good Neurologic Outcome Stratified by Rearrest –

Resuscitation outcomes survival to hospital discharge and MRS Abbreviations: ED: emergency department, MRS: modified Rankin Scale, PH: prehospital

Figure 2.. Immediate Pre-ROSC Quantitative Waveform Measures Stratified by Rearrest and ALPS Treatment Arm –

QWM are shown for each ALPS trial treatment arm and stratified by rearrest status for the VF signal immediately prior to defibrillation resulting in ROSC. Actual QWM magnitudes are expressed on a single y-axis, though units are not individually indicated. Abbreviations: ALPS: Amiodarone-Lidocaine-Placebo Study, AMSA: amplitude spectrum area, QWM: quantitative waveform measures, ROSC: return of spontaneous circulation, VF: ventricular fibrillation