Subarachnoid hemorrhage and cerebral vasospasm - literature review

A V Ciurea, C Palade, D Voinescu, D A Nica, A V Ciurea, C Palade, D Voinescu, D A Nica

Abstract

Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity. Two important areas are becoming the central research interest of subarachnoid hemorrhage: cerebral vasospasm and early brain injury. The authors have reviewed the major contributions in experimental subarachnoid hemorrhage documented in the medical literature in the past 5 years. Treatments interfering with nitric oxide - or endothelin-pathways continue to show antispasmotic effects in experimental models of subarachnoid hemorrhage. Inflammation and oxidative stress play a vital role in the pathophysiology of cerebral vasospasm. Apoptosis, a relevant cause of early brain injury after subarachnoid hemorrhage, also underline the etiology of cerebral vasospasm. Future research studies will continue to elucidate the pathophysiological pathways and treatment modalities targeting cerebral vasospasm and early brain injury, enabling an improvement in outcome for patients with subarachnoid hemorrhage.

Keywords: Apoptosis; Early brain injury; Hypoxia induced factor-1; Nitrous oxide.

References

    1. Ansar S, Vikman P. Cerebrovascular ETB, 5 HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2007;293:3750–3758.
    1. Ayer RE, Zhang JH. Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir Suppl. 2008;104:33–41.
    1. Baranova O, Miranda LF. Neuron specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci. 2007;27:6320–6332.
    1. Barbosa MD, Arthur AS. The novel 5 lipoxygenase inhibitor ABT 761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage. Neurosurgery. 2001;49:1205–1212.
    1. Bederson JB, Germano IM. Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke. 1995;26:1086–1091.
    1. Bowman G, Bonneau RH. A novel inhibitor of inflammatory production (CNI 1493) reduces rodent post hemorrhagic vasospasm. Neurocrit Care. 2006;5:222–229.
    1. Broderick JP, Brott TJ. Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage. Stroke. 1994;25:1342–1347.
    1. Cahill J, Zhang JH. Subarachnoid hemorrhage: is it time for a new direction? . Stroke. 2009;40:86–87.
    1. Cahill J, Calvert JW. Vasospasm and p53 induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke. 2006;37:1868–1874.
    1. Cahill WJ, Calvert JH. Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006;26:1341–1353.
    1. Che X, Ye W. Monocyte chemoat tractant protein 1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res. 2001;902:171–177.
    1. Chen G, Wu J. Potential role of JAK2 in cerebral vasospasm after experimental subarachnoid hemorrhage. Brain Res. 2008;1214:136–144.
    1. Chen G, Zhang S. Effects of recombinant human erythropoietin (rhEPO) on the JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. 2009;45:162–168.
    1. Chen W, Ostrowski RP. Prodeath or pro survival: two facets of hypoxia inducible factor 1 in perinatal brain injury. Exp Neurol. 2009;216:7–15.
    1. Cheng G, Wei L. Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase dependent apoptosis pathway. BMC Neurosci. 2009;10:7.
    1. Dietrich HH, Dacey RG. Molecular keys to the problems of cerebral vasospasm. Neurosurgery. 2000;46:517–530.
    1. Dorsch NW. Cerebral arterial spasm a clinical review. Br J Neurosurg. 1995;9:403–412.
    1. Dumont AS, Dumont RJ. Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Neurosurgery. 2003;53:123–133.
    1. Endo H, Nito C. Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase 3beta survival signaling. J Cereb Blood Flow Metab. 2007;27:975–982.
    1. Ersahin M, Toklu HZ. Melatonin reduces experimental subarachnoid hemorrhage induced oxidative brain damage and neurological symptoms. J Pineal Res. 2009;46:324–332.
    1. Frykholm P, Andersson JL. Haemodynamic and metabolic disturbances in the acute stage of subarachnoid haemorrhage demonstrated by PET. Acta Neural Scand. 2004;109:25–32.
    1. Helton R, Cui J. Brain specific knock out of hypoxia inducible factor 1 alpha reduces rather than increases hypoxic ischemic damage. J Neurosci. 2005;25:4099–4107.
    1. Hijdra A, Braakman R. Aneurysmal subarachnoid hemorrhage. Complications and outcome in a hospital population. Stroke. 1987;18:1061–1067.
    1. Hirano K, Kanaide H. Role of proteinase activated receptors in the vascular system. J Atheroscler Thromb. 2003;10:211–225.
    1. Hishikawa T, Ono S. Effects of deferoxamine activated hypoxia inducible factor 1 on the brainstem after subarachnoid hemorrhage in rats. Neurosurgery. 2008;62:232–240.
    1. Horky LL, Pluta RM. Role of ferrous iron chelator 2,2’ dipyridyl in preventing delayed vasospasm in a primate model of subarachnoid hemorrhage. J Neurosurg. 1998;88:298–303.
    1. Iseda K, Ono S. Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage. Neurosurg. 2007;107:128–135.
    1. Jiang Y, Wu J. Hypoxia inducible factor 1a accumulation in the brain after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab. 2002;22:L689–L696.
    1. Kai Y, Hirano K. Prevention of the hypercontractile to thrombin by proteinase activated receptor 1 antagonist in subarachnoid hemorrhage. Stroke. 2007;38:3259–3265.
    1. Karaoglan A, Akdemir O. The effect of resveratrol on vasospasm after experimental subarachnoid hemorrhage in rats. Surg Neurol. 2008;70:337–343.
    1. Kasuya H, Shimizu T. Thrombin activity in CSF after SAH is correlated with the degree of SAH the persistence of subarachnoid clot and the development vasospasm . Acta Neurochir (Wien) 1998;140:579–584.
    1. Kitaoka T, Hua Y. Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage. Stroke. 2002;33:3012–3018.
    1. Kreiter KT, Copeland D. Predictors of cognitive dysfunction after subarachnoid hemorrhage. Stroke. 2002;33:200–208.
    1. Kumagai N, Chiba Y. Involvement of pro inflammatory cytokines and microglia in an age associated neurodegeneration model, the SAMP10 mouse. Brain Res. 2007;1185:75–85.
    1. Kusaka G, Ishikawa M. Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24:916–925.
    1. Laufs U, Liao JK. Post transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J BioChem. 1998;273:24266–24271.
    1. ewen A, Matz P. Free radical pathways in CNS injury. J Neurotrauma. 2000;17:871–890.
    1. Lin CL, Shih HC. The effect of 17beta estradiol in attenuating experimental subarach noid hemorrhage induced cerebral vasospasm. J Neurosurg. 2006:298–304.
    1. Linn FH, Rinkel GJ. Incidence of subarachnoid hemorrhage: role of region, year, and rate of computed to mography: a meta analysis. Stroke. 1996;27:625–629.
    1. Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nat Med. 2008;14:497–500.
    1. Lu H, Shi JX. Expression of monocyte chemoattractant protein 1 inthe cerebral artery after experimental subarachnoid hemmorrhage. Brain Res. 2009;1262:73–80.
    1. Matz PG, Copin JC. Cell death after exposure to sub arachnoid hemolysate correlates inversely with expression of CuZn superoxide dismutase. Stroke. 2000;31:2450–2459.
    1. McGirt MJ, Blessing R. Risk of cerebral vasospasm after subarachnoid hemorrhage reduced by statin therapy: a multivariate analysis of an institutional experience. J Neurosurg. 2006;105:671–674.
    1. McGirt MJ, Lynch JR. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke . 2002;33:2950–2956.
    1. McGirt MJ, Parra A. Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke. 2002;33:2317–2323.
    1. McGirt MJ, Pradilla G. Systemic administration of simavastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm. Neurosurgery. 2006;58:945–951.
    1. Mori T, Nagata K. Intracisternal increase of superoxide anion production in a canine subarachnoid hemorrhage model. Stroke. 2001;32:636–642.
    1. Nishihashi T, Trandafir CC. Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage. J Pharmacol Sci. 2006;100:234–236.
    1. O’Driscoll G, Green D. Simvastatin, an HMG coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation. 1997;95:1126–1131.
    1. Ohyama H, Hosomi N. Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. Brain Res. 2001;902:264–271.
    1. Ostrowski RP, Colohan AR. Mechanisms of hyperbaric oxygen induced neuroprotection in a rat model of subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2005;25:554–571.
    1. Osuka K, Watanabe Y. Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage. J Neurotrauma. 2009;26:1157–1165.
    1. Pluta RM. Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment. Pharmacol Ther. 2005;105:23–56.
    1. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003;9:677–684.
    1. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev. 1994;46:325–415.
    1. Santhanam AV, Smith LA. Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage induced cerebral vasospasm. Stroke. 2005;36:2731–2737.
    1. Schievink Intracranial aneurysms. N Engl J Med. 1997;336:28–40.
    1. Schubert GA, Schilling L. Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser doppler flowmetry study in rats. J Neurosurg. 2008;109:1134–1140.
    1. Semenza GL. Signal transduction to hypoxia inducible factor 1. Biochem Pharmacol. 2002;64:993–998.
    1. Sen O, Caner H. The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage. Neurol Res. 2006;28:859–863.
    1. Shih HC, Lin CL. 17beta estradiol inhibits subarachnoid hemorrhage induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transsaction. Stroke. 2006;37:3025–3031.
    1. Shih HC, Lin CL. Upregulation of estrogen receptor alpha and mediation of 17beta estradiol vasoprotective effects via estrogen receptor alpha in basilar arteries in rats after experimental subarachnoid hemorrhage. J Neurosurg. 2008;109:92–99.
    1. Sugawara T, Ayer R. Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endo thelial nitric oxide synthase. J Neurosci Res. 2008;86:3635–3643.
    1. Sugawara T, Jadhav V. Thrombin inhibition by argatroban ameliorate early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats. Stroke. 2009;40:1530–1532.
    1. Tsurutani H, Ohkuma H. Effects of thrombin inhibitor on thrombin related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model. Stroke. 2003;34:1497–1500.
    1. Vatter H, Weidauer S. Persistence of the nitric oxide dependent vasodilator pathway of cerebral vessels after experimental subarachnoid hemorrhage. Neurosurgery. 2007;60:179–187.
    1. Vatter H, Konczalla J. Characterization of the endothelin B receptor expression and vasomotor function during experimental cerebral vasospasm. Neurosurgery. 2007;60:1100–1108.
    1. Voldby B, Enevoldsen EM. Intracranial pressure changes following aneurysm rupture. Part 1: clinical and angiographic correlations. J Neurosurg. 1982;56:186–196.
    1. Wardlaw JM, White PM. The detection and management of unruptured intracranial aneurysms. Brain. 2000;123:205–221.
    1. Wilkins RH. Cerebral vasospasm. Crit Rev Neurobiol. 1990;6:51–77.
    1. Yamaji T, Johshita H. Endothelin family in human plasma and cerebrospinal fluid. J Clin Endocrinol Metab. 1990;71:1611–1615.
    1. Yan J, Chen C. 2 methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats. Exp Neurol. 2006;202:348–356.
    1. Yanagisawa M, Kurihara H. Novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415.
    1. Zhou C, Yamaguchi M. Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24:419–431.
    1. Zhou ML, Shi JX. Potential contribution of nuclear factor kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. J Cereb Blood Flow Metab. 2007;27:1583–1592.
    1. Zimmermann M, Seifer V. Endothelin and subarachnoid hemorrhage: an overview. Neurosurgery. 1998;43:863–875.

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