Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART

Bharathi Upadhya, Nicholas M Pajewski, Michael V Rocco, W Gregory Hundley, Gerard Aurigemma, Craig A Hamilton, Jeffrey T Bates, Jiang He, Jing Chen, Michel Chonchol, Steve P Glasser, Adriana M Hung, Roberto Pisoni, Henry Punzi, Mark A Supiano, Robert Toto, Addison Taylor, Dalane W Kitzman, SPRINT Research Group, Bharathi Upadhya, Nicholas M Pajewski, Michael V Rocco, W Gregory Hundley, Gerard Aurigemma, Craig A Hamilton, Jeffrey T Bates, Jiang He, Jing Chen, Michel Chonchol, Steve P Glasser, Adriana M Hung, Roberto Pisoni, Henry Punzi, Mark A Supiano, Robert Toto, Addison Taylor, Dalane W Kitzman, SPRINT Research Group

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT01206062.

Keywords: aging; blood pressure; elasticity; heart failure; magnetic resonance imaging.

Figures

Figure 1.
Figure 1.
A explains pulse wave velocity. B shows the aortic distensibility C. Phase-contrast gradient-echo cardiography images of the ascending thoracic aorta from a participant with healthy controls, healthy aging and patients with stiff aorta. The blackened silhouettes on the images of the aorta represent the difference in aortic area between end and end systole. Cardiac cycle-dependent change in aortic area decreased with advancing age and, importantly, were most reduced in older participants with stiff aorta (Part of the image reproduced with permission from reference ) PWV=pulse wave velocity, D=distance, DT=time
Figure 2.
Figure 2.
CONSORT diagram of SPRINT HEART SPRINT=Systolic Blood Pressure Intervention Trial, SBP= systolic blood pressure, CMRI= cardiovascular magnetic resonance imaging; CVD=cardiovascular disease
Figure 3.
Figure 3.
Systolic Blood Pressure (SBP) for participants in SPRINT-HEART through the-18 month follow-up visit. Points denote mean SBP, 95% confidence intervals.

Source: PubMed

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