Understanding and reducing disability in older adults following critical illness

Abstract

Objective: To review how disability can develop in older adults with critical illness and to explore ways to reduce long-term disability following critical illness.

Data sources: We searched PubMed, CINAHL, Web of Science and Google Scholar for studies reporting disability outcomes (i.e., activities of daily living, instrumental activities of daily living, and mobility activities) and/or cognitive outcomes among patients treated in an ICU who were 65 years or older. We also reviewed the bibliographies of relevant citations to identify additional citations.

Study selection: We identified 19 studies evaluating disability outcomes in critically ill patients who were 65 years and older.

Data extraction: Descriptive epidemiologic data on disability after critical illness.

Data synthesis: Newly acquired disability in activities of daily living, instrumental activities of daily living, and mobility activities was commonplace among older adults who survived a critical illness. Incident dementia and less severe cognitive impairment were also highly prevalent. Factors related to the acute critical illness, ICU practices, such as heavy sedation, physical restraints, and immobility, as well as aging physiology, and coexisting geriatric conditions can combine to result in these poor outcomes.

Conclusions: Older adults who survive critical illness have physical and cognitive declines resulting in disability at greater rates than hospitalized, noncritically ill and community dwelling older adults. Interventions derived from widely available geriatric care models in use outside of the ICU, which address modifiable risk factors including immobility and delirium, are associated with improved functional and cognitive outcomes and can be used to complement ICU-focused models such as the ABCDEs.

Conflict of interest statement

Conflicts of Interest:

The other authors report no other conflicts of interest.

Copyright form disclosures: Dr. Brummel received grant support and support for article research from the National Institutes of Health (NIH). Dr. Balas consulted for ProCe, the France Foundation, Hospira, Hillrom, Centers for Disease Control, and Cynosure Health. Her institution received grant support from the Alzheimer’s Association and from the Robert Wood Johnson Foundation Interdisciplinary Nursing Quality Research Initiative. Dr. Ferrante received support for article research from the NIH. Her institution received grant support from the NIA/NIH. Thomas M. Gill C/F (received grant support from the NIH; received support for article research from the NIH. Dr. Ely received grant support from the NIH and VA; consulted for Hospira, Abbott, Orion, and Masimo; and received support for article research from the NIH. Dr. Morandi disclosed that he does not have any potential conflicts of interest.

Figures

Figure 1

A conceptual model of the disablement process and its application to a survivor of a critical illness. This framework illustrates how diseases (pathology) result in body system dysfunction (impairments) that limits an individual’s ability to perform basic actions (functional limitations) and prevent that individual from performing socially expected activities (disability). When applied to a hypothetical survivor of critical illness, the effects of critical illness alter the functioning of skeletal muscle and the brain to result in the inability to move one’s arms and legs as well as to remember and think clearly, preventing the patient from carrying out activities necessary to live independently such as ADLs (dressing, bathing, walking across a room), IADLs (managing money, cooking a meal) or to remain employed. ARDS, the acute respiratory distress syndrome; ICU, intensive care unit; ADLs, activities of daily living; IADLs, instrumental activities of daily living. Adapted with permission from Verbrugge LM, Jette AM. The disablement process. Social Science & Medicine 1994;38(1):1–14.

Figure 2

Interventions adapted for the ICU from geriatric care models may be used to improve care for older adults with critical illness. PT/OT, Physical and Occupational Therapy; ACE, Acute care for elders; GEM, Geriatric evaluation and management