An intensive behavioral weight loss intervention and hot flushes in women
Alison J Huang, Leslee L Subak, Rena Wing, Delia Smith West, Alexandra L Hernandez, Judy Macer, Deborah Grady, Program to Reduce Incontinence by Diet and Exercise Investigators, Frank Franklin, Holly E Richter, Kathryn L Burgio, Leslie Abdo, Charlotte Bragg, Kathy Carter, Juan Dunlap, Stacey Gilbert, Sara Hannum, Anne Hubbell, Karen Marshall, Lisa Pair, Penny Pierce, Clara Smith, Sue Thompson, Janet Turman, Audrey Wrenn, Rena Wing, Amy Gorin, Deborah Myers, Tammy Monk, Rheanna Ata, Megan Butryn, Pamela Coward, Linda Gay, Jacki Hecht, Anita Lepore-Ally, Heather Niemeier, Yael Nillini, Angela Pinto, Deborah Ranslow-Robles, Natalie Robinson, Deborah Sepinwall, Margaret E Hahn, Vivian W Sung, Victoria Winn, Nicole Zobel, Delia Smith West, Gary Foster, Deborah Grady, Leslee L Subak, Judith Macer, Ann Chang, Jennifer Creasman, Judy Quan, Eric Vittinghoff, Jennifer Yang, John W Kusek, Leroy M Nyberg, Ingrid Nygaard, Leslie Kalish, Charles Nager, Patrick M O'Neil, Cynthia S Rand, William D Steers, Alison J Huang, Leslee L Subak, Rena Wing, Delia Smith West, Alexandra L Hernandez, Judy Macer, Deborah Grady, Program to Reduce Incontinence by Diet and Exercise Investigators, Frank Franklin, Holly E Richter, Kathryn L Burgio, Leslie Abdo, Charlotte Bragg, Kathy Carter, Juan Dunlap, Stacey Gilbert, Sara Hannum, Anne Hubbell, Karen Marshall, Lisa Pair, Penny Pierce, Clara Smith, Sue Thompson, Janet Turman, Audrey Wrenn, Rena Wing, Amy Gorin, Deborah Myers, Tammy Monk, Rheanna Ata, Megan Butryn, Pamela Coward, Linda Gay, Jacki Hecht, Anita Lepore-Ally, Heather Niemeier, Yael Nillini, Angela Pinto, Deborah Ranslow-Robles, Natalie Robinson, Deborah Sepinwall, Margaret E Hahn, Vivian W Sung, Victoria Winn, Nicole Zobel, Delia Smith West, Gary Foster, Deborah Grady, Leslee L Subak, Judith Macer, Ann Chang, Jennifer Creasman, Judy Quan, Eric Vittinghoff, Jennifer Yang, John W Kusek, Leroy M Nyberg, Ingrid Nygaard, Leslie Kalish, Charles Nager, Patrick M O'Neil, Cynthia S Rand, William D Steers
Abstract
Background: Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear.
Methods: Self-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors.
Results: Approximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89).
Conclusion: Among women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control. Trial Registration clinicaltrials.gov Identifier: NCT00091988.
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Source: PubMed