Hearing loss and quality of life in survivors of paediatric CNS tumours and other cancers

Annette Weiss, Grit Sommer, Christina Schindera, Laura Wengenroth, Axel Karow, Manuel Diezi, Gisela Michel, Claudia E Kuehni, Swiss Paediatric Oncology Group (SPOG), R Ammann, K Scheinemann, M Ansari, M Beck Popovic, P Brazzola, J Greiner, M Grotzer, H Hengartner, T Kuehne, J Rössler, F Niggli, F Schilling, N von der Weid, Annette Weiss, Grit Sommer, Christina Schindera, Laura Wengenroth, Axel Karow, Manuel Diezi, Gisela Michel, Claudia E Kuehni, Swiss Paediatric Oncology Group (SPOG), R Ammann, K Scheinemann, M Ansari, M Beck Popovic, P Brazzola, J Greiner, M Grotzer, H Hengartner, T Kuehne, J Rössler, F Niggli, F Schilling, N von der Weid

Abstract

Purpose: Hearing loss, a complication of cancer treatment, may reduce health-related quality of life (HRQoL), especially in childhood cancer survivors of central nervous system (CNS) tumours who often have multiple late effects. We examined the effect of hearing loss on HRQoL in young survivors of CNS and other childhood cancers.

Methods: Within the Swiss Childhood Cancer Survivor Study, we sent questionnaires about hearing loss and HRQoL (KIDSCREEN-27) to parents of survivors aged 8-15 years. We stratified the effect of hearing loss on HRQoL by cancer diagnosis, using multivariable logistic regression and adjusting for sociodemographic and clinical factors.

Results: Hearing loss was associated with impaired physical well-being [unadjusted estimated differences - 4.6 (CI - 9.2, - 0.1); adjusted - 4.0 (CI - 7.6, - 0.3)] and peers and social support [unadjusted - 6.7 (CI - 13.0, - 0.3); adjusted - 5.0 (CI - 10.5, 0.9)] scores in survivors of CNS tumours (n = 123), but not in children diagnosed with other cancers (all p-values > 0.20, n = 577).

Conclusion: Clinicians should be alert to signs of reduced physical well-being and impaired relationships with peers. Especially survivors of CNS tumours may benefit most from strict audiological monitoring and timely intervention to mitigate secondary consequences of hearing loss on HRQoL.

Trial registration: ClinicalTrials.gov NCT03297034.

Keywords: Cancer treatment; Childhood cancer; Late effects; Ototoxicity; Swiss Childhood Cancer Registry; Swiss Childhood Cancer Survivor Study.

References

    1. Bone Marrow Transplant. 2000 Jun;25(11):1191-6
    1. Clin Psychol Rev. 2002 May;22(4):547-85
    1. Cancer. 2005 Apr 1;103(7):1457-67
    1. Pediatr Blood Cancer. 2005 Sep;45(3):324-32
    1. Cancer. 2005 Oct 15;104(8):1751-60
    1. Qual Life Res. 2007 Oct;16(8):1347-56
    1. Pediatrics. 2007 Nov;120(5):e1229-36
    1. Swiss Med Wkly. 2007 Sep 8;137(35-36):502-9
    1. Health Qual Life Outcomes. 2007 Dec 03;5:65
    1. Eur J Oncol Nurs. 2008 Jul;12(3):209-16
    1. Pediatr Blood Cancer. 2011 Apr;56(4):646-53
    1. Brain Inj. 2012;26(3):270-81
    1. Int J Epidemiol. 2012 Dec;41(6):1553-64
    1. Health Qual Life Outcomes. 2013 Jun 13;11:96
    1. Acta Oncol. 2014 Apr;53(4):486-92
    1. Pediatr Blood Cancer. 2015 Mar;62(3):375-84
    1. Qual Life Res. 2015 Sep;24(9):2151-61
    1. Cancer. 2015 Nov 15;121(22):4053-61
    1. Swiss Med Wkly. 2015 Dec 23;145:w14225
    1. Pediatr Blood Cancer. 2016 Apr;63(4):677-83
    1. Cancer. 2016 Jun 1;122(11):1647-58
    1. Otolaryngol Head Neck Surg. 2016 Aug;155(2):208-19
    1. Pediatr Blood Cancer. 2016 Sep;63(9):1615-21
    1. PLoS One. 2017 Mar 23;12(3):e0174479
    1. Pediatr Blood Cancer. 2018 Mar;65(3):null

Source: PubMed

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