Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention

W Jack Rejeski, Robert Axtell, Roger Fielding, Jeffrey Katula, Abby C King, Todd M Manini, Anthony P Marsh, Marco Pahor, Alvito Rego, Catrine Tudor-Locke, Mark Newman, Michael P Walkup, Michael E Miller, LIFE Study Investigator Group, Marco Pahor, Jack M Guralnik, Stephen D Anton, Thomas W Buford, Christiaan Leeuwenburgh, Susan G Nayfield, Todd M Manini, Connie Caudle, Lauren Crump, Latonia Holmes, Jocelyn Lee, Ronald Lester, Ching-ju Lu, Michael E Miller, Mark A Espeland, Walter T Ambrosius, William Applegate, Don Babcock, Daniel P Beavers, Robert P Byington, Delilah Cook, Curt D Furberg, Candace Goode, Jason Griffin, Lea N Harvin, Leora Henkin, John Hepler, Fang-Chi Hsu, Kathy Joyce, Laura Lovato, Wesley Roberson, Julia Robertson, Julia Rushing, Scott Rushing, Cynthia L Stowe, Michael P Walkup, Don Hire, W Jack Rejeski, Jeffrey A Katula, Peter H Brubaker, Shannon L Mihalko, Janine M Jennings, Kathy Lane, John Luopa, Sherri Moore, Hoa V Teuschler, Evan C Hadley, Sergei Romashkan, Denise E Bonds, Kushang V Patel, Mary M McDermott, Bonnie Spring, Joshua Hauser, Diana Kerwin, Kathryn Domanchuk, Rex Graff, Alvito Rego, Timothy S Church, Steven N Blair, Valerie H Myers, Nathan E Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Rodarte, Heidi K Millet, Catrine Tudor-Locke, Ben P Butitta, Sheletta G Donatto, Shannon H Cocreham, Abby C King, Cynthia M Castro, William L Haskell, Randall S Stafford, Veronica Yank, Leslie A Pruitt, Kathy Berra, Carol Bell, Rosita M Thiessen, Kate P Youngman, Selene B Virgen, Eric Maldonado, Kristina N Tarin, Heather Klaftenegger, Carolyn A Prosak, Ines Campero, Dulce M Garcia, José Soto, Linda Chio, David Hoskins, Roger A Fielding, Miriam E Nelson, Sara C Folta, Edward M Phillips, Christine K Liu, Erica C Cifarelli, Kieran F Reid, Paige C Lacasse, Dylan R Kirn, Evan P Pasha, Karen R Ruais, Won S Kim, Julie M Krol, Vince E Beard, Eleni X Tsiroyannis, Cynthia Hau, Todd M Manini, Marco Pahor, Stephen D Anton, Thomas W Buford, Michael Marsiske, Susan G Nayfield, Bhanuprasad D Sandesara, Mieniecia L Black, William L Burk, Brian M Hoover, Jeffrey D Knaggs, William C Marena, Irina Korytov, Stephanie D Curtis, Megan S Lorow, Chaitalee S Goswami, Melissa A Lewis, Michelle Kamen, Jill N Bitz, Brian K Stanton, Tamika T Hicks, Charles W Gay, Chonglun Xie, Holly L Morris, Floris F Singletary, Jackie Causer, Susan Yonce, Katie A Radcliff, Mallorey Picone Smith, Jennifer S Scott, Melissa M Rodriguez, Margo S Fitch, Mendy C Dunn, Jessica Q Schllesinger, Anne B Newman, Stephanie A Studenski, Bret H Goodpaster, Oscar Lopez, Nancy W Glynn, Neelesh K Nadkarni, Diane G Ives, Mark A Newman, George Grove, Kathy Williams, Janet T Bonk, Jennifer Rush, Piera Kost, Pamela Vincent, Allison Gerger, Jamie Romeo, Lauren C Monheim, Stephen B Kritchevsky, Anthony P Marsh, Tina E Brinkley, Jamehl S Demons, Kaycee M Sink, Kimberly Kennedy, Rachel Shertzer-Skinner, Abbie Wrights, Rose Fries, Deborah Barr, Thomas M Gill, Robert S Axtell, Susan S Kashaf, Nathalie de Rekeneire, Joanne M McGloin, Karen C Wu, Lynne P Iannone, Raeleen Mautner, Denise M Shepard, Barbara Fennelly, Theresa Sweeney Barnett, Sean N Halpin, Matthew J Brennan, Julie A Bugaj, Maria A Zenoni, Bridget M Mignosa, Sharon M Huie-White, Janice Zocher, Jeff Williamson, Kaycee M Sink, Hugh C Hendrie, Stephen R Rapp, Joe Verghese, Nancy Woolard, Mark Espeland, Janine Jennings, Carl J Pepine, Mario Ariet, Eileen Handberg, Daniel Deluca, James Hill, Anita Szady, Geoffrey L Chupp, Gail M Flynn, Thomas M Gill, John L Hankinson, Carlos A Vaz Fragoso, Erik J Groessl, Robert M Kaplan, W Jack Rejeski, Robert Axtell, Roger Fielding, Jeffrey Katula, Abby C King, Todd M Manini, Anthony P Marsh, Marco Pahor, Alvito Rego, Catrine Tudor-Locke, Mark Newman, Michael P Walkup, Michael E Miller, LIFE Study Investigator Group, Marco Pahor, Jack M Guralnik, Stephen D Anton, Thomas W Buford, Christiaan Leeuwenburgh, Susan G Nayfield, Todd M Manini, Connie Caudle, Lauren Crump, Latonia Holmes, Jocelyn Lee, Ronald Lester, Ching-ju Lu, Michael E Miller, Mark A Espeland, Walter T Ambrosius, William Applegate, Don Babcock, Daniel P Beavers, Robert P Byington, Delilah Cook, Curt D Furberg, Candace Goode, Jason Griffin, Lea N Harvin, Leora Henkin, John Hepler, Fang-Chi Hsu, Kathy Joyce, Laura Lovato, Wesley Roberson, Julia Robertson, Julia Rushing, Scott Rushing, Cynthia L Stowe, Michael P Walkup, Don Hire, W Jack Rejeski, Jeffrey A Katula, Peter H Brubaker, Shannon L Mihalko, Janine M Jennings, Kathy Lane, John Luopa, Sherri Moore, Hoa V Teuschler, Evan C Hadley, Sergei Romashkan, Denise E Bonds, Kushang V Patel, Mary M McDermott, Bonnie Spring, Joshua Hauser, Diana Kerwin, Kathryn Domanchuk, Rex Graff, Alvito Rego, Timothy S Church, Steven N Blair, Valerie H Myers, Nathan E Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Rodarte, Heidi K Millet, Catrine Tudor-Locke, Ben P Butitta, Sheletta G Donatto, Shannon H Cocreham, Abby C King, Cynthia M Castro, William L Haskell, Randall S Stafford, Veronica Yank, Leslie A Pruitt, Kathy Berra, Carol Bell, Rosita M Thiessen, Kate P Youngman, Selene B Virgen, Eric Maldonado, Kristina N Tarin, Heather Klaftenegger, Carolyn A Prosak, Ines Campero, Dulce M Garcia, José Soto, Linda Chio, David Hoskins, Roger A Fielding, Miriam E Nelson, Sara C Folta, Edward M Phillips, Christine K Liu, Erica C Cifarelli, Kieran F Reid, Paige C Lacasse, Dylan R Kirn, Evan P Pasha, Karen R Ruais, Won S Kim, Julie M Krol, Vince E Beard, Eleni X Tsiroyannis, Cynthia Hau, Todd M Manini, Marco Pahor, Stephen D Anton, Thomas W Buford, Michael Marsiske, Susan G Nayfield, Bhanuprasad D Sandesara, Mieniecia L Black, William L Burk, Brian M Hoover, Jeffrey D Knaggs, William C Marena, Irina Korytov, Stephanie D Curtis, Megan S Lorow, Chaitalee S Goswami, Melissa A Lewis, Michelle Kamen, Jill N Bitz, Brian K Stanton, Tamika T Hicks, Charles W Gay, Chonglun Xie, Holly L Morris, Floris F Singletary, Jackie Causer, Susan Yonce, Katie A Radcliff, Mallorey Picone Smith, Jennifer S Scott, Melissa M Rodriguez, Margo S Fitch, Mendy C Dunn, Jessica Q Schllesinger, Anne B Newman, Stephanie A Studenski, Bret H Goodpaster, Oscar Lopez, Nancy W Glynn, Neelesh K Nadkarni, Diane G Ives, Mark A Newman, George Grove, Kathy Williams, Janet T Bonk, Jennifer Rush, Piera Kost, Pamela Vincent, Allison Gerger, Jamie Romeo, Lauren C Monheim, Stephen B Kritchevsky, Anthony P Marsh, Tina E Brinkley, Jamehl S Demons, Kaycee M Sink, Kimberly Kennedy, Rachel Shertzer-Skinner, Abbie Wrights, Rose Fries, Deborah Barr, Thomas M Gill, Robert S Axtell, Susan S Kashaf, Nathalie de Rekeneire, Joanne M McGloin, Karen C Wu, Lynne P Iannone, Raeleen Mautner, Denise M Shepard, Barbara Fennelly, Theresa Sweeney Barnett, Sean N Halpin, Matthew J Brennan, Julie A Bugaj, Maria A Zenoni, Bridget M Mignosa, Sharon M Huie-White, Janice Zocher, Jeff Williamson, Kaycee M Sink, Hugh C Hendrie, Stephen R Rapp, Joe Verghese, Nancy Woolard, Mark Espeland, Janine Jennings, Carl J Pepine, Mario Ariet, Eileen Handberg, Daniel Deluca, James Hill, Anita Szady, Geoffrey L Chupp, Gail M Flynn, Thomas M Gill, John L Hankinson, Carlos A Vaz Fragoso, Erik J Groessl, Robert M Kaplan

Abstract

The Lifestyle Interventions and Independence for Elders (LIFE) Study is a Phase III randomized controlled clinical trial (Clinicaltrials.gov identifier: NCT01072500) that will provide definitive evidence regarding the effect of physical activity (PA) on major mobility disability in older adults (70-89 years old) who have compromised physical function. This paper describes the methods employed in the delivery of the LIFE Study PA intervention, providing insight into how we promoted adherence and monitored the fidelity of treatment. Data are presented on participants' motives and self-perceptions at the onset of the trial along with accelerometry data on patterns of PA during exercise training. Prior to the onset of training, 31.4% of participants noted slight conflict with being able to meet the demands of the program and 6.4% indicated that the degree of conflict would be moderate. Accelerometry data collected during PA training revealed that the average intensity - 1,555 counts/minute for men and 1,237 counts/minute for women - was well below the cutoff point used to classify exercise as being of moderate intensity or higher for adults. Also, a sizable subgroup required one or more rest stops. These data illustrate that it is not feasible to have a single exercise prescription for older adults with compromised function. Moreover, the concept of what constitutes "moderate" exercise or an appropriate volume of work is dictated by the physical capacities of each individual and the level of comfort/stability in actually executing a specific prescription.

Keywords: accelerometry; aging; compromised physical function; older adults; physical disability.

Figures

Figure 1
Figure 1
Panels (A–C) represent three representative accelerometry recordings from center-based exercise training. Notes: In (AC), the y-axis represents counts/minute, whereas the x-axis is the minute-by-minute time course for the training bout. The horizontal red “+” marks represent the median counts/minute achieved across the activity session; the blue circles represent the counts achieved for a given minute of activity; the horizontal blue “+” marks indicate rest periods and identify the number of the rest period with a numeric superscript, if any rest intervals were taken. The participant in Figure 1A is exercising well above the standard adult cutoff point for moderate-intensity exercise (2,690 counts/minute21) and has a very consistent pace across the entire exercise bout. The participants in Figure 1B and C have median activity counts well below the adult cutoff point for moderate PA with the individual in Figure 1C being the most compromised. Note that the person in Figure 1B exhibits a high degree of variability in intensity and had to take a 6-min rest stop. Such patterns are common for participants with joint pain or various chronic health conditions.

References

    1. Administration on Aging (AoA) Profile of older Americans [web page on the Internet] Washington DC: AoA; 2011Available from: Accessed May 13, 2013
    1. Katz S, Branch LG, Branson MH, Papsidero JA, Beck JC, Greer DS. Active life expectancy. N Engl J Med. 1983;309(20):1218–1224.
    1. Fried LP, Bandeen-Roche K, Chaves PH, Johnson BA. Preclinical mobility disability predicts incident mobility disability in older women. J Gerontol A Biol Sci Med Sci. 2000;55(1):M43–M52.
    1. Rejeski WJ, Focht BC, Messier SP, Morgan T, Pahor M, Penninx B. Obese, older adults with knee osteoarthritis: weight loss, exercise, and quality of life. Health Psychol. 2002;21(5):419–426.
    1. LIFE Study Investigators. Pahor M, Blair SN, et al. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006;61(11):1157–1165.
    1. University of Florida The LIFE Study – Lifestyle Interventions and Independence for Elders [website on the Internet] Bethseda, MD: US National Library of Medicine; 2010[updated March 29, 2013]. Available from: . NLM identifier: NCT01072500Accessed July 24, 2013
    1. Fielding RA, Rejeski WJ, Blair S, et al. LIFE Research Group The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226–1237.
    1. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85–M94.
    1. Rejeski WJ, Brawley LR, Jung ME. Self-management in geriatric medicine. In: Halter J, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, editors. Hazzard’s Principles of Geriatric Medicine and Gerontology. 6th ed. New York, NY: McGraw-Hill; 2008.
    1. Bandura A. Social Foundations of Thought and Action: A Social Cognitive Theory. Englewood Cliffs, NJ: Prentice-Hall; 1986.
    1. Brawley L, Rejeski WJ, Gaukstern JE, Ambrosius WT. Social cognitive changes following weight loss and physical activity interventions in obese, older adults in poor cardiovascular health. Ann Behav Med. 2012;44(3):353–364.
    1. Rejeski WJ, Brawley LR, Ambrosius W, et al. Older adults with chronic disease: benefits of group-mediated counseling in the promotion of physically active lifestyles. Health Psychol. 2003;22(4):414–423.
    1. Rejeski WJ, Brubaker PH, Goff DC, Jr, et al. Translating weight loss and physical activity programs into the community to preserve mobility in older, obese adults in poor cardiovascular health. Arch Intern Med. 2011;171(10):880–886.
    1. D’Zurilla TJ, Nezu AM. Problem-solving Therapy: A Social Competence Approach to Clinical Intervention. 2nd ed. New York, NY: Springer; 1999.
    1. Nordgren LF, van der Pligt J, van Harreveld F. The instability of health cognitions: visceral states influence self-efficacy and related health beliefs. Health Psychol. 2008;27(6):722–727.
    1. Rejeski WJ, Gauvin L. The embodied and relational nature of the mind: implications for clinical interventions in aging individuals and populations. Clin Interv Aging. 2013;85:657–665.
    1. Marcus BH, Banspach SW, Lefebvre RC, Rossi JS, Carleton RA, Abrams DB. Using the stages of change model to increase the adoption of physical activity among community participants. Am J Health Promot. 1992;6(6):424–429.
    1. Marsh AP, Lovato LC, Glynn NW, et al. Lifestyle Interventions and Independence for Elders Study: Recruitment and Baseline Characteristics. J Gerontol A Bioll Sci Med Sci. 2013 May 28; Epub.
    1. Rejeski WJ, Marsh AP, Chmelo E, Rejeski JJ. Obesity, intentional weight loss and physical disability in older adults. Obes Rev. 2010;11(9):671–685.
    1. Manini TM, Newman AB, Fielding R, et al. LIFE Research Group Effects of exercise on mobility in obese and nonobese older adults. Obesity (Silver Spring) 2010;18(6):1168–1175.
    1. Messier SP, Loeser RF, Miller GD, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum. 2004;50(5):1501–1510.
    1. Sasaki JE, John D, Freedson PS. Validation and comparison of ActiGraph activity monitors. J Sci Med Sport. 2011;14(5):411–416.
    1. Bracht GH, Glass GV. The external validity of experiments. Am Educ Res J. 1968;5(4):437–474.

Source: PubMed

3
Subscribe