Associations between physical activity, sedentary behavior, and urinary oxidized guanine in colorectal cancer patients: results from the ColoCare Study
Richard Viskochil, Biljana Gigic, Tengda Lin, Stephanie Skender, Jürgen Böhm, Petra Schrotz-King, Karen Steindorf, Robert Owen, Jane C Figueiredo, Christopher I Li, Erin M Siegel, Sheetal Hardikar, David Shibata, Adetunji T Toriola, Martin Schneider, Alexis Ulrich, Cornelia M Ulrich, Jennifer Ose, Richard Viskochil, Biljana Gigic, Tengda Lin, Stephanie Skender, Jürgen Böhm, Petra Schrotz-King, Karen Steindorf, Robert Owen, Jane C Figueiredo, Christopher I Li, Erin M Siegel, Sheetal Hardikar, David Shibata, Adetunji T Toriola, Martin Schneider, Alexis Ulrich, Cornelia M Ulrich, Jennifer Ose
Abstract
To determine associations between physical activity (PA), sedentary behavior (SB), and oxidative stress in colorectal cancer patients, ColoCare Study participants in Germany wore an accelerometer 6 and/or 12 months after surgery. Spearman partial correlations were used to assess associations between PA and urinary concentrations of oxidized guanine, a validated marker of oxidative stress. There were no significant associations between PA or SB and oxidized guanine in n = 76 measurements (ng/mg creatinine; r = 0.03, p = 0.76 for PA, r = -0.05, p = 0.69 for SB). Novelty Objectively measured PA was not associated with a marker of oxidative stress in colorectal cancer patients.
Keywords: 8-OHdG; accelerometer; accéléromètre; cancer colorectal; colorectal cancer; durée de la sédentarité; oxidative stress; sedentary time; stress oxydatif.
Conflict of interest statement
Conflicts of interest: CMU has as cancer center director oversight over research funded by several pharmaceutical companies, but has not received funding directly herself. The other authors declare no conflicts of interest.
Source: PubMed