Human adipose-derived mesenchymal progenitor cells plus microfracture and hyaluronic acid for cartilage repair: a Phase IIa trial
Zhiguang Qiao, Jiaxin Tang, Bing Yue, Jinwu Wang, Jun Zhang, Liang Xuan, Chengxiang Dai, Suke Li, Meng Li, Cuili Xu, Kerong Dai, You Wang, Zhiguang Qiao, Jiaxin Tang, Bing Yue, Jinwu Wang, Jun Zhang, Liang Xuan, Chengxiang Dai, Suke Li, Meng Li, Cuili Xu, Kerong Dai, You Wang
Abstract
Aim: This study aimed to preliminarily evaluate the safety and efficacy of human adipose-derived mesenchymal progenitor cells (haMPCs) in combination with microfracture and hyaluronic acid (HA) for treating cartilage defects. Materials & methods: A total of 30 patients with medial femoro-tibial condylar cartilage defects were randomized into three groups: arthroscopic microfracture group and normal saline injection, arthroscopic microfracture and intra-articular injection of HA, or arthroscopic microfracture in combination with intra-articular injection of HA and haMPCs. Results & conclusions: The data demonstrated that intra-articular injection of haMPCs plus microfracture and HA is a safe procedure to improve joint function in patients with knee cartilage defects. These findings provide an impetus for future research on this treatment. ClinicalTrials.gov Identifier: NCT02855073.
Keywords: Artz; Re-Join®; cartilage defect; cartilage regeneration; human adipose-derived mesenchymal progenitor cells; microfracture.
Source: PubMed