Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease
Carmen Jorge, Adriano Targa, Iván David Benítez, Faride Dakterzada, Gerard Torres, Olga Minguez, Anna Carnes, Montse Pujol, Aurora Gibert, Ricard López, Anna Michela Gaeta, Mireia Dalmases, Ramón Farré, Manuel Sánchez-de-la-Torre, Ferran Barbé, Gerard Piñol-Ripoll, Carmen Jorge, Adriano Targa, Iván David Benítez, Faride Dakterzada, Gerard Torres, Olga Minguez, Anna Carnes, Montse Pujol, Aurora Gibert, Ricard López, Anna Michela Gaeta, Mireia Dalmases, Ramón Farré, Manuel Sánchez-de-la-Torre, Ferran Barbé, Gerard Piñol-Ripoll
Abstract
We evaluated the influence of untreated obstructive sleep apnoea (OSA) on the magnitude of cognitive decline and on several cognitive subdomains in patients with mild-to-moderate Alzheimer's disease.In this single-centre study, 144 patients were recruited prospectively from a cognitive impairment unit and underwent overnight polysomnography.The mean±sd change in the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) score at 12 months was 3.19±5.61 in the non-OSA group and 0.08±5.62 in the OSA group, with an intergroup difference of -3.36 (95% CI 0.19-0.16; p=0.002). We did not observe a significant difference in any cognitive subdomains at 12 months. Regarding Mini-Mental State Examination scores at 36 months, the mean change was 1.69 (95% CI -1.26-4.64; p=0.445). No significant differences were found among different OSA severity groups.We observed that ADAS-cog scores were better in the OSA group than in the non-OSA group by a statistically but not clinically significant margin. We did not find differences in the different cognitive subdomains after 1 year or in global cognition after 3 years of follow-up.
Trial registration: ClinicalTrials.gov NCT02814045.
Conflict of interest statement
Conflict of interest: C. Jorge has nothing to disclose. Conflict of interest: A. Targa has nothing to disclose. Conflict of interest: I.D. Benítez has nothing to disclose. Conflict of interest: F. Dakterzada has nothing to disclose. Conflict of interest: G. Torres has nothing to disclose. Conflict of interest: O. Minguez has nothing to disclose. Conflict of interest: A. Carnes has nothing to disclose. Conflict of interest: M. Pujol has nothing to disclose. Conflict of interest: A. Gibert has nothing to disclose. Conflict of interest: R. López has nothing to disclose. Conflict of interest: A.M. Gaeta has nothing to disclose. Conflict of interest: M. Dalmases has nothing to disclose. Conflict of interest: R. Farré has nothing to disclose. Conflict of interest: M. Sánchez-de-la-Torre has nothing to disclose. Conflict of interest: F. Barbé has nothing to disclose. Conflict of interest: G. Piñol-Ripoll has nothing to disclose.
Copyright ©ERS 2020.
Source: PubMed