Relationship between clinical outcome measures and parent proxy reports of health-related quality of life in ambulatory children with Duchenne muscular dystrophy

Abstract

In Duchenne muscular dystrophy, data directly linking changes in clinical outcome measures to patient-perceived well-being are lacking. This study evaluated the relationship between clinical outcome measures used in clinical trials of ambulatory Duchenne muscular dystrophy (Vignos functional grade, quantitative knee extension strength, timed functional performance measures, and gait velocity) and 2 health-related quality of life measures--the Pediatric Outcomes Data Collection Instrument and Pediatric Quality of Life Inventory-in 52 ambulatory Duchenne muscular dystrophy subjects and 36 controls. Those with the disease showed significant decrements in parent proxy-reported health-related quality of life measures versus controls across all domains. The Pediatric Outcomes Data Collection Instrument transfers/basic mobility and sports/ physical function and the Pediatric Quality of Life Inventory physical functioning domains had significant associations with age (and hence disease progression) and traditional clinical outcome measures employed in clinical trials of ambulatory boys with Duchenne muscular dystrophy. Selected domains of the Pediatric Outcomes Data Collection Instrument and generic Pediatric Quality of Life Inventory are potential patient-reported outcome measures for clinical trials in ambulatory individuals with the disease.

Conflict of interest statement

The authors have no conflicts of interest to disclose with regard to this article.

Figures

Figure 1

Definitions of Duchenne muscular dystrophy (DMD) severity level for ambulatory DMD (■) and typically developing control males (□) based on 10 m walk/run test scores plotted by age. Group I: 12 seconds.

Figure 2

Figure 2a: PODCI Transfers/Basic Mobility Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2b: PODCI Sports/Physical Functioning Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2c: PedsQL Physical Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PedsQL: Pediatric Quality of Life Inventory™.

Figure 2

Figure 2a: PODCI Transfers/Basic Mobility Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2b: PODCI Sports/Physical Functioning Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2c: PedsQL Physical Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PedsQL: Pediatric Quality of Life Inventory™.

Figure 2

Figure 2a: PODCI Transfers/Basic Mobility Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2b: PODCI Sports/Physical Functioning Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PODCI: Pediatric Outcomes Data Collection Instrument. Figure 2c: PedsQL Physical Domain Scores by age group for DMD and Control subjects. DMD: Duchenne muscular dystrophy; PedsQL: Pediatric Quality of Life Inventory™.