Longitudinal study of lung function in pregnant women: Influence of parity and smoking

Luciana Duzolina Manfré Pastro, Miriam Lemos, Frederico Leon Arrabal Fernandes, Silvia Regina Dias Médici Saldiva, Sandra Elisabete Vieira, Beatriz Mangueira Saraiva Romanholo, Paulo Hilário Nascimento Saldiva, Rossana Pulcineli Vieira Francisco, Luciana Duzolina Manfré Pastro, Miriam Lemos, Frederico Leon Arrabal Fernandes, Silvia Regina Dias Médici Saldiva, Sandra Elisabete Vieira, Beatriz Mangueira Saraiva Romanholo, Paulo Hilário Nascimento Saldiva, Rossana Pulcineli Vieira Francisco

Abstract

Objectives: To evaluate pulmonary function in the first and third trimesters of pregnancy and analyze the influence of parity and smoking on spirometry parameters.

Methods: This longitudinal prospective study included a cohort of 120 pregnant women. The inclusion criteria were as follows: singleton pregnancy, gestational age less than 13.86 weeks, and no preexisting maternal diseases. The exclusion criteria were as follows: change of address, abortion, and inadequate spirometry testing. ClinicalTrials.gov: NCT02807038.

Results: A decrease in values of forced vital capacity and forced expiratory volume were noted in the first second from the first to third trimester. In the first and third trimesters, multiparous women demonstrated lower absolute forced vital capacity and forced expiratory volume values in the first second compared with nulliparous women (p<0.0001 and p=0.001, respectively). Multiparous women demonstrated reduced forced expiratory flow in 25% to 75% of the maneuver compared with nulliparous women in the first (p=0.005) and third (p=0.031) trimesters. The absolute values of forced expiratory flow in 25% to 75%, forced expiratory volume in the first second and predicted peak expiratory flow values in the third trimester were higher in smokers compared with nonsmokers (p=0.042, p=0.039, p=0.024, and p=0.021, respectively).

Conclusion: There was a significant reduction in forced vital capacity and forced expiratory volume values in the first second during pregnancy. Parity and smoking significantly influence spirometric variables.

Conflict of interest statement

No potential conflict of interest was reported.

References

    1. Gupta L, Dixit R. A linear study of pulmonary function tests in normal pregnant and non-pregnant women. J Indian Med Assoc. 2013;111((10)):666–9.
    1. Tan EK, Tan EL. Alterations in physiology and anatomy during pregnancy. Best Pract Res Clin Obstet Gynaecol. 2013;27((6)):791–802. doi: 10.1016/j.bpobgyn.2013.08.001.
    1. Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. Clin Chest Med. 2011;32((1)):1–13. doi: 10.1016/j.ccm.2010.11.001.
    1. Kolarzyk E, Szot WM, Lyszczarz J. Lung function and breathing regulation parameters during pregnancy. Arch Gynecol Obstet. 2005;272((1)):53–8. doi: 10.1007/s00404-004-0691-1.
    1. Pereira C. Diretrizes para o teste de função pulmonar da Sociedade Brasileira de pneumologia e tisiologia–Espirometria. J Pneumol. 2002:1–82.
    1. American Thoracic Society. Standardization of Spirometry, 1994 Update. Am J Respir Crit Care Med. 1995;152((3)):1107–36. doi: 10.1164/ajrccm.152.3.7663792.
    1. Grindheim G, Toska K, Estensen ME, Rosseland LA. Changes in pulmonary function during pregnancy: a longitudinal cohort study. BJOG. 2012;119((1)):94–101. doi: 10.1111/j.1471-0528.2011.03158.x.
    1. Mbatchou Ngahane BH, Afane Ze E, Chebu C, Mapoure NY, Temfack E, Nganda M, et al. Effects of cooking fuel smoke on respiratory symptoms and lung function in semi-rural women in Cameroon. Int J Occup Environ Health. 2015;21((1)):61–5. doi: 10.1179/2049396714Y.0000000090.
    1. Schikowski T, Schaffner E, Meier F, Phuleria HC, Vierkötter A, Schindler C, et al. Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort. Environ Health Perspect. 2013;121((9)):1034–9. doi: 10.1289/ehp.1206145.
    1. Redivo MB. Avaliação da função pulmonar em gestantes no período gestacional entre 28 a 36 semanas. Universidade do Sul de Santa Catarina; 2007.
    1. Neeraj, Sodhi C, Pramod J, Singh J, Kaur V. Effect of advanced uncomplicated pregnancy on pulmonary function parameters of North Indian subjects. Indian J Physiol Pharmacol. 2010;54((1)):69–72.
    1. Ogbodo S, Nwagha U, Okaka A, Okeke A, Chukwurah F, Ezeonu P. Low levels of some nutritional parameters of pregnant women in a rural community of South East Nigeria: implications for the attainment of the millennium developmental goal. Ann Med Health Sci Res. 2012;2((1)):49–55. doi: 10.4103/2141-9248.96939.
    1. Suárez López de Vergara RG, Fernández C, Oliva Hernández C, Doménech Martínez E, Dorta Delgado JM, Dorta Suárez M. Lung function and exposure to tobacco smoke among adolescents. An Pediatr. 2007;67((6)):559–66. doi: 10.1016/S1695-4033(07)70804-4.
    1. Prasad BK, Sahay AP, Singh AK. Smoking women and their lung function tests. Kathmandu Univ Med J (KUMJ) 2004;2((2)):142–4.

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