Antimicrobial drug resistance in Singapore hospitals

Li-Yang Hsu, Thean-Yen Tan, Roland Jureen, Tse-Hsien Koh, Prabha Krishnan, Raymond Tzer-Pin Lin, Nancy Wen-Sin Tee, Paul Ananth Tambyah, Li-Yang Hsu, Thean-Yen Tan, Roland Jureen, Tse-Hsien Koh, Prabha Krishnan, Raymond Tzer-Pin Lin, Nancy Wen-Sin Tee, Paul Ananth Tambyah

Abstract

A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), and third-generation cephalosporin resistance among Klebsiella pneumoniae (35.9%) hospital isolates in 2006. Antimicrobial drug resistance is a major problem in Singapore.

Figures

Figure
Figure
Incidence density of various antimicrobial drug–resistant bacteria isolated in public sector hospitals, Singapore, 2006. White bars, incidence density, all isolates (per 1,000 inpatient-days); gray bars, incidence density, blood isolates (per 1,000 inpatient-days); black bars, incidence density, intensive-care unit (ICU) isolates (per 1,000 ICU inpatient-days). S. aureus, Staphylococcus aureus; E. coli, Escherichia coli; P. aeruginosa, Pseudomonas aeruginosa.

References

    1. Spellberg B, Powers JH, Brass EP, Miller LG, Edwards JE Jr. Trends in antimicrobial drug development: implications for the future. Clin Infect Dis. 2004;38:1279–86. 10.1086/420937
    1. Talbot GH, Bradley J, Edwards JE Jr, Gilbert D, Scheld M, Bartlett JG, et al. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis. 2006;42:657–68. 10.1086/499819
    1. Simonsen GS, Tapsall JW, Allegranzi B, Talbot EA, Lazzari S. The antimicrobial resistance containment and surveillance approach – a public health tool. Bull World Health Organ. 2004;82:928–34.
    1. Australian Group on Antimicrobial Resistance (AGAR) [cited 2007 Feb 10]. Available from
    1. European Antimicrobial Resistance Surveillance System (EARSS) [cited 2007 Feb 10]. Available from
    1. Ministry of Health. Singapore. Health Facilities [cited 2007 Feb 10]. Available from
    1. Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Supplement M100–S14, Vol 24(1). Wayne (PA): The Institute; 2005.
    1. Bell SM, Gatus BJ, Pham JN, Rafferty DL. Antibiotic susceptibility testing by the CDS method. A manual for medical and veterinary laboratories. Randwick (Australia): The Antibiotic Reference Laboratory Services, South Eastern Area Laboratory Services; 2005.
    1. Clinical Laboratory Standards Institute. Analysis and presentation of cumulative susceptibility test data; approved guideline – 2nd ed. Document M39–A2. Vol 25(28). Wayne (PA): The Institute; 2006.
    1. Hirakata Y, Matsuda J, Miyazaki Y, Kamihira S, Kawakami S, Miyazawa Y, et al. Regional variation in the prevalence of extended-spectrum beta-lactamse-producing clinical isolates in the Asia-Pacific region (SENTRY 1998–2002). Diagn Microbiol Infect Dis. 2005;52:323–9. 10.1016/j.diagmicrobio.2005.04.004
    1. Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, et al. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin. Antimicrob Agents Chemother. 2004;48:4926–8. 10.1128/AAC.48.12.4926-4928.2004
    1. Koh TH, Sng LH, Wang GC, Hsu LY, Zhao Y. IMP-4 and OXA beta-lactamases in Acinetobacter baumannii from Singapore. J Antimicrob Chemother. 2007;59:627–32. 10.1093/jac/dkl544

Source: PubMed

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