Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN): protocol for a prospective international multicenter register of cardiac arrest in children

Jimena Del Castillo, Débora Sanz, Laura Herrera, Jesús López-Herce, Grupo de Estudio de Parada Cardiaca Intrahospitalaria en la Infancia, Cristina Calvo, Carmen Campos, Sonia Cañadas, Juan Carlos de Carlos, Maria Concepción Goñi, Ramón Hernández, Ana Jordá, Juan Mayordomo, Abián Montesdeoca, Antonio Morales, Sara Moralo, Ana Muñoz, Aránzazu Olloqui, Antonio Rodriguez, María Luisa Serrano, Jimena Del Castillo, Débora Sanz, Laura Herrera, Jesús López-Herce, Grupo de Estudio de Parada Cardiaca Intrahospitalaria en la Infancia, Cristina Calvo, Carmen Campos, Sonia Cañadas, Juan Carlos de Carlos, Maria Concepción Goñi, Ramón Hernández, Ana Jordá, Juan Mayordomo, Abián Montesdeoca, Antonio Morales, Sara Moralo, Ana Muñoz, Aránzazu Olloqui, Antonio Rodriguez, María Luisa Serrano

Abstract

Background and aims: Cardiac arrest (CA) in children is a major public health problem. Thanks to advances in cardiopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. However, pediatric CA has a very high mortality. In the treatment of in-hospital CA there are still multiple controversies. The objective of this study is to develop a multicenter and international registry of in-hospital pediatric cardiac arrest including the diversity of management in different clinical and social contexts. Participation in this register will enable the evaluation of the diagnosis of CA, CPR and post-resuscitation care and its influence in survival and neurological prognosis.

Methods: An intrahospital CA data recording protocol has been designed following the Utstein model. Database is hosted according to European legislation regarding patient data protection. It is drafted in English and Spanish. Invitation to participate has been sent to Spanish, European and Latinamerican hospitals. Variables included, asses hospital characteristics, the resuscitation team, patient's demographics and background, CPR, post-resuscitation care, mortality, survival and long-term evolution. Survival at hospital discharge will be evaluated as a primary outcome and survival with good neurological status as a secondary outcome, analyzing the different factors involved in them. The study design is prospective, observational registry of a cohort of pediatric CA.

Conclusions: This study represents the development of a registry of in-hospital CA in childhood. Its development will provide access to CPR data in different hospital settings and will allow the analysis of current controversies in the treatment of pediatric CA and post-resuscitation care. The results may contribute to the development of further international recommendations. Trial register: ClinicalTrials.gov Identifier: NCT04675918. Registered 19 December 2020 - Retrospectively registered, https://ichgcp.net/clinical-trials-registry/NCT04675918?cond=pediatric+cardiac+arrest&draw=2&rank=10.

Keywords: Cardiac arrest; Clinical registry; In-hospital; Pediatric cardiac arrest; Resuscitation.

Conflict of interest statement

The authors declare that they have no competing interests.

© 2021. The Author(s).

Figures

Fig. 1
Fig. 1
CONSORT (Consolidated Standards of Reporting Trials) flow diagram. IHCA: In-hospital Cardiac Arrest; ECMO: Extracorporeal Membrane Oxygenation; VAD: Ventricular Assistance Device

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