Otitis media with effusion and atopy: is there a causal relationship?

Mario E Zernotti, Ruby Pawankar, Ignacio Ansotegui, Hector Badellino, Juan Sebastian Croce, Elham Hossny, Motohiro Ebisawa, Nelson Rosario, Mario Sanchez Borges, Yuan Zhang, Luo Zhang, Mario E Zernotti, Ruby Pawankar, Ignacio Ansotegui, Hector Badellino, Juan Sebastian Croce, Elham Hossny, Motohiro Ebisawa, Nelson Rosario, Mario Sanchez Borges, Yuan Zhang, Luo Zhang

Abstract

Otitis Media with Effusion (OME) is an inflammatory condition of the middle ear cleft, acute or chronic, with collection of fluid in the middle ear with an intact tympanic membrane. It is a very common disease in childhood, the most frequent cause of hearing loss in childhood and often requiring surgery. OME is called chronic when the fluid in the middle ear persists for more than three months or when the episodes recur six or more times in one year. The current article covers various aspects of OME including definition, epidemiology. Pathomechanisms, risk factors, role of allergy in OME, impact of upper airway disease on OME, eosinophilic otitis media and management of OME.

Keywords: Allergy; Infancy; Inflammation; eosinophilic otititis media; OME; Rhinosinusitis; Risk factors.

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

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Competing interests

The authors reported they have no conflicts of interest regarding this paper.

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Figures

Fig. 1
Fig. 1
Pathogenesis of OME. Underlying factors. ET: eustachian tube; ME: middle ear; AOM: acute otitis media; OME: otitis media with effusion

References

    1. Kenna MA. Otitis Media and the new guidelines. J Otolaryngol. 2005;34(suppl 1):S24–32.
    1. Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin N Am. 2008;41:311–323. doi: 10.1016/j.otc.2007.11.004.
    1. Senturia BS, Bluestone CD, Klein JO, et al. Report or the ad hoc committee on definition and classification of otitis media with effusion. Ann Otol Rhinol Laryngol. 1980;89:3–4. doi: 10.1177/00034894800890S303.
    1. Engel J, Anteunis L, et al. Risk factors of otitis media with effusion during infancy. Int J Pediatr Otorhinolaryngol. 1999;48:239–249. doi: 10.1016/S0165-5876(99)00037-3.
    1. Elicora SS, Ozturk M, Sevinc R, Derin S, Dinc AE, Erdem D. Risk factors for otitis media effusion in children who have adenoid hypertrophia. Int J Pediatr Otorhinolaryngol. 2015;79(3):374–377. doi: 10.1016/j.ijporl.2014.12.030.
    1. Alles R, Parish A, Scadding G, et al. The prevalence of atopic disorders in children with chronic otitis media with effusion. Pediatr Allergy Immunol. 2001;12:102–106. doi: 10.1046/j.0905-6157.2000.00008.x.
    1. Minovi A, Dazert S. Diseases of the middle ear in childhood. GSM Current Topics in Otorhinolaryngology-Head and Neck Surgery. 2014;13:1–29.
    1. Roditi RE, Veling M, Shin JJ. Age: an effect modifier of the association between allergic rhinitis and otitis media with effusion. Laryngoscope 2015 (Epub ahead of print).
    1. Quaranta N, Iannuzzi L, Gelardi M. Does the type of rhinitis influence development of otitis media with effusion in children? Curr Allergy Asthma Rep. 2014;14:472–477. doi: 10.1007/s11882-014-0472-2.
    1. Kreiner-Moller E, Chawes LK, et al. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–1620. doi: 10.1111/j.1365-2222.2012.04038.x.
    1. Gravel JS, Wallace IF. Effects of otitis media with effusion on hearing in the first 3 years of life. J Speech Lang Hear Res. 2000;43(3):631–644. doi: 10.1044/jslhr.4303.631.
    1. Madell JR. Impact of otitis media on auditory function. In: Rosenfeld RM, Bluestone CD, editors. Evidence-based otitis media. Canada: B.C. Decker Inc; 1999. pp. 337–351.
    1. Rosenfeld RM, Culpepper L, Doyle KJ, et al. Clinical practice guideline: otitis media with effusion. Otolaryngol Head Neck Surg. 2004;130(5 Suppl):S95–118. doi: 10.1016/j.otohns.2004.02.002.
    1. Tomioka S, Yuasa R, Iino Y: Intractable otitis media in cases with bronchial asthma. In Recent Advances in Otitis Media: Proceedings of the Second Extraordinary International Symposium on Recent Advances in Otitis Media. Edited by Mogi G, Honjo I, Ishii T, et al.: ).
    1. Takata GS, Chan LS, Morphew T, et al. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. Pediatrics. 2003;112(6):1379–1387. doi: 10.1542/peds.112.6.1379.
    1. Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara T. Improvement of eosinophilic otitis media by optimized asthma treatment. Allergy Asthma Immunol Res. 2013;5(3):175–178. doi: 10.4168/aair.2013.5.3.175.
    1. Nakagawa T, Matsubara A, Shiratsuchi H, et al. Intractable otitis media with eosinophils: importance of diagnosis and validity of treatment for hearing preservation. ORL J Otorhinolaryngol Relat Spec. 2006;68:118–122. doi: 10.1159/000091215.
    1. Haruna S, Yoshikawa M, Otori N, Moriyama H. Relationship between eosinophilic sinusitis and eosinophilic otitis media [in Japanese] Otol Rhino Laryngol Tokyo. 2003;46:472–480.
    1. Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2001;119:1670–1672.
    1. Iino Y, Nagamine H, Yabe T, Matsutani S. Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma. Clin Exp Allergy. 2001;31:1135–1143. doi: 10.1046/j.1365-2222.2001.01134.x.
    1. Nonaka M, Fukumoto A, Ozu C, Pawankar R, et al. IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion. Acta Otolaryngol. 2003;123:383–387. doi: 10.1080/0036554021000028117.
    1. Iino Y, Kakizaki K, Katano H, et al. Eosinophil chemoattractant in middle ear patients with eosinophilic otitis media. Clin Exp Allergy. 2005;35:1370–1376. doi: 10.1111/j.1365-2222.2005.02330.x.
    1. Kanazawa H, Yoshida N, Shinnabe A, Iino Y. Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media. Ann Allergy Asthma Immunol. 2014;113(1):88–92. doi: 10.1016/j.anai.2014.04.021.
    1. Hurst DS, Amin K, Sevéus L, Venge P. Mast cells and tryptase in the middle ear of children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 1999;49(Suppl 1):S315–S319. doi: 10.1016/S0165-5876(99)00184-6.
    1. Daly KA, Hoffman HJ, Kvaerner KJ, Kvestad E, Casselbrant ML, Homoe P, et al. Epidemiology, natural history, and risk factors: panel report from the ninth international research conference on otitis media. Int J Pediatr Otorhinolaryngol. 2010;74:231–240. doi: 10.1016/j.ijporl.2009.09.006.
    1. Caye-Thomasen P, Hermansson A, Bakaletz L, Hellstrom S, Kanzaki S, Kerschner J, et al. Panel 3: recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis. Otolaryngol Head Neck Surg. 2013;148:E37–E51. doi: 10.1177/0194599813476257.
    1. Martines F, Bentivegna D, Maira E, Sciacca V, Martines E. Risk factors for otitis media with effusion: case-control study in Sicilian schoolchildren. Int J Pediatr Otorhinolaryngol. 2011;75:754–759. doi: 10.1016/j.ijporl.2011.01.031.
    1. Portmann M. The etiology and pathogenesis of otitis media with effusion. A review Acta Otolaryngol Suppl. 1984;414:41–44. doi: 10.3109/00016488409122880.
    1. Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin Otolaryngol Allied Sci. 2000;25:181–194. doi: 10.1046/j.1365-2273.2000.00350.x.
    1. Ryding M, White P, Kalm O. Eustachian tube function and tympanic membrane findings after chronic secretory otitis media. Int J Pediatr Otorhinolaryngol. 2004;68:197–204. doi: 10.1016/j.ijporl.2003.10.013.
    1. Kuo CL, Lien CF, Chu CH, Shiao AS. Otitis media with effusion in children with cleft lip and palate: a narrative review. Int J Pediatr Otorhinolaryngol. 2013;77:1403–1409. doi: 10.1016/j.ijporl.2013.07.015.
    1. Maris M, Wojciechowski M, Van de Heyning P, Boudewyns A. A cross-sectional analysis of otitis media with effusion in children with down syndrome. Eur J Pediatr. 2014;173:1319–1325. doi: 10.1007/s00431-014-2323-5.
    1. Austeng ME, Akre H, Overland B, Abdelnoor M, Falkenberg ES, Kvaerner KJ. Otitis media with effusion in children with in down syndrome. Int J Pediatr Otorhinolaryngol. 2013;77:1329–1332. doi: 10.1016/j.ijporl.2013.05.027.
    1. Mittal R, Kodiyan J, Gerring R, Mathee K, Li JD, Grati M, et al. Role of innate immunity in the pathogenesis of otitis media. Int J Infect Dis. 2014;29:259–267. doi: 10.1016/j.ijid.2014.10.015.
    1. Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011;11:78–84. doi: 10.1007/s11882-010-0158-3.
    1. Chantzi FM, Kafetzis DA, Bairamis T, Avramidou C, Paleologou N, Grimani I, et al. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion. Allergy. 2006;61:332–336. doi: 10.1111/j.1398-9995.2006.00971.x.
    1. Bakaletz LO. Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. Paediatr Respir Rev. 2012;13:154–159. doi: 10.1016/j.prrv.2012.03.001.
    1. Daniel M, Imtiaz-Umer S, Fergie N, Birchall JP, Bayston R. Bacterial involvement in otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2012;76:1416–1422. doi: 10.1016/j.ijporl.2012.06.013.
    1. Allen EK, Chen WM, Weeks DE, Chen F, Hou X, Mattos JL, et al. A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. J Assoc Res Otolaryngol. 2013;14:791–800. doi: 10.1007/s10162-013-0411-2.
    1. MacArthur CJ, Wilmot B, Wang L, Schuller M, Lighthall J, Trune D. Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms. Laryngoscope. 2014;124:1229–1235. doi: 10.1002/lary.24349.
    1. Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media - prevention and treatment. Infect Drug Resist. 2014;7:15–24.
    1. Hall-Stoodley L, Hu FZ, Gieseke A, Nistico L, Nguyen D, Hayes J, et al. Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA. 2006;296:202–211. doi: 10.1001/jama.296.2.202.
    1. Martines F, Martinciglio G, Martines E, Bentivegna D. The role of atopy in otitis media with effusion among primary school children: audiological investigation. Eur Arch Otorhinolaryngol. 2010;267:1673–1678. doi: 10.1007/s00405-010-1297-9.
    1. Hurst DS. The role of allergy in otitis media with effusion. Otolaryngol Clin N Am. 2011;44:637–654. doi: 10.1016/j.otc.2011.03.009.
    1. Lack G, Caulfield H, Penagos M. The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol. 2011;22:258–266. doi: 10.1111/j.1399-3038.2010.01130.x.
    1. Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin N Am. 2008;41:311–323. doi: 10.1016/j.otc.2007.11.004.
    1. Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children. Lancet. 2002;359:493. doi: 10.1016/S0140-6736(02)07665-1.
    1. Umapathy D, Alles R, Scadding GK. A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school children. Int J Pediatr Otorhinolaryngol. 2007;71:705–712. doi: 10.1016/j.ijporl.2006.12.017.
    1. Caylan R, Bektas D, Atalay C, Korkmaz O. Prevalence and risk factors of otitis media with effusion in Trabzon, a city in northeastern Turkey, with an emphasis on the recommendation of OME screening. Eur Arch Otorhinolaryngol. 2006;263:404–408. doi: 10.1007/s00405-005-1023-1.
    1. Tong MC, Yue V, Ku PK, Lo PS, Wong EM, van Hasselt CA. Risk factors for otitis media with effusion in Chinese schoolchildren: a nested case-control study and review of the literature. Int J Pediatr Otorhinolaryngol. 2006;70:213–219. doi: 10.1016/j.ijporl.2005.06.004.
    1. Rovers MM, de Kok IM, Schilder AG. Risk factors for otitis media: an international perspective. Int J Pediatr Otorhinolaryngol. 2006;70:1251–6.28. doi: 10.1016/j.ijporl.2006.01.003.
    1. Kiris M, Muderris T, Kara T, Bercin S, Cankaya H, Sevil E. Prevalence and risk factors of otitis media with effusion in school children in eastern Anatolia. Int J Pediatr Otorhinolaryngol. 2012;76:1030–1035. doi: 10.1016/j.ijporl.2012.03.027.
    1. Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM. Otitis media. Lancet. 2004;363:465–473. doi: 10.1016/S0140-6736(04)15495-0.
    1. MacArthur CJ, Pillers DA, Pang J, Kempton JB, Trune DR. Altered expression of middle and inner ear cytokines in mouse otitis media. Laryngoscope. 2011;121:365–371. doi: 10.1002/lary.21349.
    1. Daly KA, Hunter LL, Levine SC, Lindgren BR, Giebink GS. Relationships between otitis media sequelae and age. Laryngoscope. 1998;108:1306–1310. doi: 10.1097/00005537-199809000-00008.
    1. Johnston LC, Feldman HM, Paradise JL, Bernard BS, Colborn DK, Casselbrant ML, et al. Tympanic membrane abnormalities and hearing levels at the ages of 5 and 6 years in relation to persistent otitis media and tympanostomy tube insertion in the first 3 years of life: a prospective study incorporating a randomized clinical trial. Pediatrics. 2004;114:e58–e67. doi: 10.1542/peds.114.1.e58.
    1. Grevers G. Challenges in reducing the burden of otitis media disease: an ENT perspective on improving management and prospects for prevention. Int J Pediatr Otorhinolaryngol. 2010;74:572–577. doi: 10.1016/j.ijporl.2010.03.049.
    1. Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope. 2003;113:1645–1657. doi: 10.1097/00005537-200310000-00004.
    1. Hardjojo A, Shek LP, van Bever HP, Lee BW. Rhinitis in children less than 6 years of age: current knowledge and challenges. Asia Pac Allergy. 2011;1:115–122. doi: 10.5415/apallergy.2011.1.3.115.
    1. Quaranta N, Iannuzzi L, Gelardi M. Does the type of rhinitis influence development of otitis media with effusion in children? Curr Allergy Asthma Rep. 2014;14:472. doi: 10.1007/s11882-014-0472-2.
    1. Smirnova MG, Birchall JP, Pearson JP. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediat Inflamm. 2004;13:75–88. doi: 10.1080/09629350410001688477.
    1. Pelikan Z. Role of nasal allergy in chronic secretory otitis media. Curr Allergy Asthma Rep. 2009;9:107–113. doi: 10.1007/s11882-009-0016-3.
    1. Marseglia GL, Pagella F, Caimmi D, Caimmi S, Castellazzi AM, Poddighe D, Klersy C, Ciprandi G. Increased risk of otitis media with effusion in allergic children presenting with adenoiditis. Otolaryngol Head Neck Surg. 2008;138:572–575. doi: 10.1016/j.otohns.2008.01.020.
    1. Kreiner-Møller E, Chawes BL, Caye-Thomasen P, Bønnelykke K, Bisgaard H. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–1620. doi: 10.1111/j.1365-2222.2012.04038.x.
    1. Passali D, Passali GC, Lauriello M, Romano A, Bellussi L, Passali FM. Nasal allergy and otitis media: a real correlation? Sultan Qaboos Univ Med J. 2014;14:e59–e64. doi: 10.12816/0003337.
    1. Hurst DS, Venge P. Evidence of eosinophil, neutrophil, and mast-cell mediators in the effusion of OME patients with and without atopy. Allergy. 2000;55:435–441. doi: 10.1034/j.1398-9995.2000.00289.x.
    1. Zielnik-Jurkiewicz B, Stankiewicz-Szymczak -inflammatory interleukins in middle ear effusions from atopic and non-atopic children with chronic otitis media with effusion. Eur Arch Otorhinolaryngol 2015 Jun 16. [Epub ahead of print].
    1. Williamson I, Benge S, Barton S, Petrou S, Letley L, Fasey N, Abangma G, Dakin H, Little P. A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technol Assess. 2009;13:1–144. doi: 10.3310/hta13370.
    1. MacIntyre EA, Chen CM, Herbarth O, Borte M, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J, LISA Study Group Early-life otitis media and incident atopic disease at school age in a birth cohort. Pediatr Infect Dis J. 2010;29:e96–e99. doi: 10.1097/INF.0b013e3181fcd9e8.
    1. Thomson JA, Widjaja C, Darmaputra AA, Lowe A, Matheson MC, Bennett CM, Allen K, Abramson MJ, Hosking C, Hill D, Dharmage SC. Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: a prospective study of allergy-prone children from birth to six years. Pediatr Allergy Immunol. 2010;21:1076–1085. doi: 10.1111/j.1399-3038.2010.01018.x.
    1. MacIntyre EA, Heinrich J. Otitis media in infancy and the development of asthma and atopic disease. Curr Allergy Asthma Rep. 2012;12:547–550. doi: 10.1007/s11882-012-0308-x.
    1. Kwon C, Lee HY, Kim MG, Boo SH, Yeo SG. Allergic diseases in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2013;77:158–161. doi: 10.1016/j.ijporl.2012.09.039.
    1. Bernstein JM, Lee J, Conboy K, Ellis E, Li P. Further observations on the role of IgE-mediated hypersensivity in recurrent otitis media with effusion. Otolaryngol Head Neck Surg. 1985;93:611–615. doi: 10.1177/019459988509300508.
    1. Becker S, Koch T, Philipp A. Allergic origin of recurrent middle ear effusion and adenoids in young children. HNO. 1991;39:182–184.
    1. Corey JP, Adham RE, Abbass AH, Seligman I. The role of IgE-mediated hypersensivity in otitis media with effusion. Am J Otolaryngol. 1994;15:138–144. doi: 10.1016/0196-0709(94)90063-9.
    1. Zhang Y, Xu M, Zhang J, Zeng L, Wang Y, Zheng QY. Risk factors for chronic and recurrent otitis media–a meta-analysis. PLoS One. 2014;9:e86397. doi: 10.1371/journal.pone.0086397.
    1. Kırıs M, Muderris T, Kara T, Bercin S, Cankaya H, Sevil E. Prevalence and risk factors of otitis media with effusion in school children in eastern Anatolia. Int J Pediatr Otorhinolaryngol. 2012;76:1030–1035. doi: 10.1016/j.ijporl.2012.03.027.
    1. Chantzi FM, Kafetzis DA, Bairamis T, Avramidou C, Paleologou N, Grimani I, Apostolopoulos N, Papadopoulos NG. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion. Allergy. 2006;61:332–336. doi: 10.1111/j.1398-9995.2006.00971.x.
    1. Nguyen LHP, Manoukian JJ, Sobol SE, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol. 2004;114:1110–1115. doi: 10.1016/j.jaci.2004.07.061.
    1. Döner F, Yariktas M, Demirci M. The role of allergy in recurrent otitis media with effusion. J Investig Allergol Clin Immunol. 2004;14:154–158.
    1. Tracy JM, Demain JG, Hoffman KM, Goetz DW. Intranasal beclomethasone as an adjunct to treatment of chronic middle ear effusion. Ann Allergy Asthma Immunol. 1998;80:198–206. doi: 10.1016/S1081-1206(10)62956-0.
    1. Mandel EM, Casselbrant ML, Rockette HE, Fireman P, Kurs-Lasky M, Bluestone CD. Systemic steroid for chronic otitis media with effusion in children. Pediatrics. 2002;110:1071–1080. doi: 10.1542/peds.110.6.1071.
    1. Nsouli TM, Nsouli SM, Linde RE, O’Mara F, Scanlon RT, Bellanti JA. Role of food allergy in serous otitis media. Ann Allergy. 1994;73:215–219.
    1. Juntti H, Tikkanen S, Kokkonen J, Alho OP, Niinimäki A. Cow’s milk allergy is associated with recurrent otitis media during childhood. Acta Otolaryngol. 1999;119:867–873. doi: 10.1080/00016489950180199.
    1. Ramakrishnan JB. The role of food allergy in otolaryngology disorders. Curr Opin Otolaryngol Head Neck Surg. 2010;18:195–199. doi: 10.1097/MOO.0b013e328337b2ca.
    1. Kanazawa H, Yoshida N, Shinnabe A, Iino Y. Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media. Ann Allergy Asthma Immunol. 2014;113:88–92. doi: 10.1016/j.anai.2014.04.021.
    1. Iino Y. Role of IgE in eosinophilic otitis media. Allergol Int. 2010;59:233–238. doi: 10.2332/allergolint.10-RAI-0223.
    1. Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara T. Improvement of eosinophilic otitis media by optimized asthma treatment. Allergy Asthma Immunol Res. 2013;5:175–178. doi: 10.4168/aair.2013.5.3.175.
    1. Okude A, Tagaya E, Kondo M, Nonaka M, Tamaoki J. A case of severe asthma with eosinophilic otitis media successfully treated with anti-IgE monoclonal antibody omalizumab. Case Rep Pulmonol. 2012;2012:340525.
    1. Tomonaga K, Kurono Y, Mogi G. The role of nasal allergy in otitis media with effusion. A clinical study. Acta Otolaryngol Suppl. 1988;458:41–47. doi: 10.3109/00016488809125100.
    1. Irander K, Borres MP, Bjorksten B. Middle ear diseases in relation to atopy and nasal metachromatic cells in infancy. Int J Pediatr Otorhinolaryngol. 1993;26:1–9. doi: 10.1016/0165-5876(93)90191-5.
    1. Stenstrom C, Ingvarsson L. General illness and need of medical care in otitis prone children. Int J Pediatr Otorhinolaryngol. 1994;29:23–32. doi: 10.1016/0165-5876(94)90105-8.
    1. Kreiner-Moller E, Chawes BL, Caye-Thomasen P, Bonnelykke K, Bisgaard H. Allergic rhinitis is associated with otitis media with effusion: a birth cohort study. Clin Exp Allergy. 2012;42:1615–1620. doi: 10.1111/j.1365-2222.2012.04038.x.
    1. Takeuchi K, Fujita Y, Tomemori T, Yuta A, Iriyoshi N, Sakakura Y. Analysis of T cell receptor beta chain repertoire in middle ear effusions. Ann Otol Rhinol Laryngol. 1996;105:213–217. doi: 10.1177/000348949610500307.
    1. Krouse JH. The unified airway--conceptual framework. Otolaryngol Clin N Am. 2008;41:257–266. doi: 10.1016/j.otc.2007.11.002.
    1. Braunstahl GJ, Overbeek SE, Kleinjan A, Prins JB, Hoogsteden HC, Fokkens WJ. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol. 2001;107:469–476. doi: 10.1067/mai.2001.113046.
    1. Grossman J. One airway, one disease. Chest. 1997;111:11S–16S. doi: 10.1378/chest.111.2_Supplement.11S.
    1. Nguyen LH, Manoukian JJ, Sobol SE, Tewfik TL, Mazer BD, Schloss MD, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol. 2004;114:1110–1115. doi: 10.1016/j.jaci.2004.07.061.
    1. Parietti-Winkler C, Baumann C, Gallet P, Gauchard G, Jankowski R. Otitis media with effusion as a marker of the inflammatory process associated to nasal polyposis. Rhinology. 2009;47:396–399.
    1. Parietti-Winkler C, Jankowski R. Is there an association between otitis media and nasal polyposis? Curr Allergy Asthma Rep. 2011;11:521–525. doi: 10.1007/s11882-011-0229-0.
    1. Ichimiya I, Kawauchi H, Mogi G. Analysis of immunocompetent cells in the middle ear mucosa. Arch Otolaryngol Head Neck Surg. 1990;116:324–330. doi: 10.1001/archotol.1990.01870030088015.
    1. Iino Y, Usubuchi H, Kodama K, Kanazawa H, Takizawa K, Kanazawa T, et al. Eosinophilic inflammation in the middle ear induces deterioration of bone-conduction hearing level in patients with eosinophilic otitis media. Otol Neurotol. 2010;31:100–104. doi: 10.1097/MAO.0b013e3181bc3781.
    1. De Schryver E, Devuyst L, Derycke L, Dullaers M, Van Zele T, Bachert C, et al. Local immunoglobulin e in the nasal mucosa: clinical implications. Allergy Asthma Immunol Res. 2015;7:321–331. doi: 10.4168/aair.2015.7.4.321.
    1. Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107:607–614. doi: 10.1067/mai.2001.112374.
    1. Roditi RE, Veling M, Shin JJ. Age: An effect modifier of the association between allergic rhinitis and otitis media with effusion. Laryngoscope. 2015; Published online ahead of print, (30 September). doi:10.1002/lary.25682.
    1. Midgley EJ, Dewey C, Pryce K, Maw AR, Study Team ALSPAC. The frequency of otitis media with effusion in British pre-school children: a guide for treatment. Clin Otolaryngol Allied Sci. 2000;25:485–491. doi: 10.1046/j.1365-2273.2000.00360.x.
    1. O’Connor RD, Ort H, Leong AB, Cook DA, Street D, Hamburger RN. Tympanometric changes following nasal antigen challenge in children with allergic rhinitis. Ann Allergy. 1984;53:468–471.
    1. Lack G, Caulfield H. Penagos M the link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol. 2011;22:258–266. doi: 10.1111/j.1399-3038.2010.01130.x.
    1. American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery and American Academy of Pediatrics, Subcommittee on Otitis Media With Effusion Otitis media with effusion: clinical practice guideline. Pediatrics. 2004;113:1412–1429. doi: 10.1542/peds.113.5.1412.

Source: PubMed

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