Nerve physiology: mechanisms of injury and recovery

Abstract

Peripheral nerve injuries are common conditions, with broad-ranging groups of symptoms depending on the severity and nerves involved. Although much knowledge exists on the mechanisms of injury and regeneration, reliable treatments that ensure full functional recovery are scarce. This review aims to summarize various ways these injuries are classified in light of decades of research on peripheral nerve injury and regeneration.

Keywords: Nerve injury; Nerve physiology; Nerve recovery; Peripheral nerve injuries.

Copyright © 2013. Published by Elsevier Inc.

Figures

Fig. 1

Classification of nerve trauma From: Tsao B, Boulis N, Bethoux F, Murray B. Trauma of the Nervous System, Peripheral Nerve Trauma. In: Daroff: Bradley's Neurology in Clinical Practice, 6th ed. 2012 p 984-1001. (Image courtesy Cleveland Clinic, 2006. Illustrator, David Schumick, BS, CMI.)

Fig. 2

The Neuromuscular Junction 1. Illustration and TEM of the neuromuscular junction. From: Lee Y, Thompson WJ. Chapter 54 - The Vertebrate Neuromuscular Junction. Muscle, 2012;2:775-787.