Comparing the Efficacy of Caudal with Intravenous Dexamethasone in the Management of Pain Following Lumbosacral Spine Surgeries: A Randomized Double Blinded Controlled Study

Sandhya Kalappa, Raghavendra Biligiri Sridhar, Saraswathi Nagappa, Sandhya Kalappa, Raghavendra Biligiri Sridhar, Saraswathi Nagappa

Abstract

Background: The challenge in providing analgesia for spine surgeries is to provide extended postoperative pain relief and simultaneously allow early neurological assessment and mobilization. Our study aimed to evaluate the analgesic efficacy of intravenous versus caudal dexamethasone in lumbosacral spine surgeries.

Materials and methods: In this prospective double-blind study, a total of 96 patients undergoing lumbosacral spine surgery were randomized into three groups to receive 25 ml of preemptive caudal epidural injection of either injection ropivacaine 0.2% (Group A, n = 32), a 25 ml of injection ropivacaine 0.2%, and intravenous injection dexamethasone 8 mg (Group B, n = 32) or 25 ml mixture of injection ropivacaine 0.2% with injection dexamethasone 8 mg (Group C, n = 32) under general anesthesia. Visual analog scale (VAS), heart rate, blood pressures, blood sugar levels, and time to rescue analgesia were recorded at regular intervals for the first 24 h. Time to discharge was noted. Analysis of variance has been used to find the significance of study parameters between the groups of patients. Statistical software, namely, SAS 9.2 and SPSS 15.0, have been used for the analysis of the data.

Results: The mean VAS was significantly lower in the Group C for up to 24 h following the caudal block. No significant hemodynamic changes were noted in any of the groups. The intravenous dexamethasone group showed higher blood glucose levels at 24 h but was not clinically relevant.

Conclusion: These results suggest that injection dexamethasone is a safe adjunct to caudal ropivacaine in lumbosacral spine surgeries.

Keywords: Analgesia; caudal; dexamethasone; intravenous; postoperative pain; ropivacaine; spine surgeries; steroids.

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Comparision of (a) Heart rate, (b) Systolic Blood Pressure (SBP), (c) Diastolic Blood Pressure (DBP) (d) Mean Arterial Pressure (MAP) distribution of the three groups studied

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